Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria

AIM: To identify the clinical profile of chronic hepatitis C patients treated with pegylated interferon plus ribavirin in Selayang Hospital from year 2004-2012. It is also to determine factors associated with treatment response. METHODS: 273 patients treated with pegylated interferon plus ribavirin...

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Main Author:	Zakaria, Adlin Nadia
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Biological laboratories and stations
Online Access:	https://ir.uitm.edu.my/id/eprint/55285/1/55285.PDF
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id	my-uitm-ir.55285
record_format	uketd_dc
spelling	my-uitm-ir.552852022-01-25T04:40:10Z Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria 2015-01 Zakaria, Adlin Nadia Biological laboratories and stations Diseases of the digestive system. Gastroenterology AIM: To identify the clinical profile of chronic hepatitis C patients treated with pegylated interferon plus ribavirin in Selayang Hospital from year 2004-2012. It is also to determine factors associated with treatment response. METHODS: 273 patients treated with pegylated interferon plus ribavirin for CHC were identified. Patient's data were accessed retrospectively through electronic medical records. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Factors with significant p value were analysed using multiple logistic regression. RESULTS: The mean age of patients treated was 44.16 (± 10.51). More men were treated compared to women (76.6% vs. 23.4%). Major ethnicity distribution was Chinese 48.7%, and Malays 38.5%. Majority of patients have very high baseline viral load (median >800,000 iu/ml). Genotype 3a predominates (58.2%), while genotype 1 come a close second (la= 20.1% and lb=12.5%). Fifty nine percent of all treated population achieved SVR. DISCUSSIONS: Twelve factors were identified as possible SVR predictors; age (p=0.002), pegylated interferon dose disruption (p=0.012), ribavirin dose disruption (p=0.223), genotype 3a (p=0.239), pre-existing diabetes mellitus type 2 (p=0.042), pre-existing kidney related disease (p=0.042), history of alcohol usage (p=0.051 ), baseline ALT (p=0.045), baseline platelet (p=0.001), liver biopsy fibrosis score (p=0.005), fibroscan reading (p=0.149), and RVR (p=0.0001). CONCLUSION: The information elucidated from this study could facilitate local physicians decide on the population of CHC patients that should receive treatment. 2015-01 Thesis https://ir.uitm.edu.my/id/eprint/55285/ https://ir.uitm.edu.my/id/eprint/55285/1/55285.PDF text en public masters Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Hassan, Yahaya Karupannan, Mahmathi
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Hassan, Yahaya Karupannan, Mahmathi
topic	Biological laboratories and stations Biological laboratories and stations
spellingShingle	Biological laboratories and stations Biological laboratories and stations Zakaria, Adlin Nadia Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
description	AIM: To identify the clinical profile of chronic hepatitis C patients treated with pegylated interferon plus ribavirin in Selayang Hospital from year 2004-2012. It is also to determine factors associated with treatment response. METHODS: 273 patients treated with pegylated interferon plus ribavirin for CHC were identified. Patient's data were accessed retrospectively through electronic medical records. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Factors with significant p value were analysed using multiple logistic regression. RESULTS: The mean age of patients treated was 44.16 (± 10.51). More men were treated compared to women (76.6% vs. 23.4%). Major ethnicity distribution was Chinese 48.7%, and Malays 38.5%. Majority of patients have very high baseline viral load (median >800,000 iu/ml). Genotype 3a predominates (58.2%), while genotype 1 come a close second (la= 20.1% and lb=12.5%). Fifty nine percent of all treated population achieved SVR. DISCUSSIONS: Twelve factors were identified as possible SVR predictors; age (p=0.002), pegylated interferon dose disruption (p=0.012), ribavirin dose disruption (p=0.223), genotype 3a (p=0.239), pre-existing diabetes mellitus type 2 (p=0.042), pre-existing kidney related disease (p=0.042), history of alcohol usage (p=0.051 ), baseline ALT (p=0.045), baseline platelet (p=0.001), liver biopsy fibrosis score (p=0.005), fibroscan reading (p=0.149), and RVR (p=0.0001). CONCLUSION: The information elucidated from this study could facilitate local physicians decide on the population of CHC patients that should receive treatment.
format	Thesis
qualification_level	Master's degree
author	Zakaria, Adlin Nadia
author_facet	Zakaria, Adlin Nadia
author_sort	Zakaria, Adlin Nadia
title	Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
title_short	Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
title_full	Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
title_fullStr	Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
title_full_unstemmed	Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria
title_sort	clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic hepatitis c patients in selayang hospital / adlin nadia zakaria
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/55285/1/55285.PDF
_version_	1783734910379360256

Clinical profile and response to treatment with pegylated interferon plus ribavirin for chronic Hepatitis C patients in Selayang Hospital / Adlin Nadia Zakaria

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