Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra

A simple and green approach for the synthesis of fused pyrano[2,3-c]pyrazole-3-carboxylate and pyrano[2,3-c]pyrazole type compounds were developed.The main objective is to synthesize the Synthesis of novel derivatives of pyrano[2.3-c]pyrazole-imine and its derived manganese complexes analogues, in a...

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Main Author:	Bouchamma, Fatima Ezzahra
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Analytical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/59086/1/59086.pdf
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id	my-uitm-ir.59086
record_format	uketd_dc
spelling	my-uitm-ir.590862022-04-29T04:20:45Z Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra 2020-11 Bouchamma, Fatima Ezzahra Analytical chemistry A simple and green approach for the synthesis of fused pyrano[2,3-c]pyrazole-3-carboxylate and pyrano[2,3-c]pyrazole type compounds were developed.The main objective is to synthesize the Synthesis of novel derivatives of pyrano[2.3-c]pyrazole-imine and its derived manganese complexes analogues, in addition of the C-C ring extension of the pyranopyrazole for the new fused pyranopyrimidine and its derivatives. The synthesis of pyrano[2,3-c]pyrazole compounds was achieved via a domino one-pot, four-component reaction of diethyl oxaloacetate, hydrazine hydrate, aldehyde and malanonitrile in refluxing acidic ethanolic solution under non-catalytic system. This four-component reaction proceeds via sequential reactions of pyrazole synthesis, Michael addition and Thorpe-Ziegler cyclization reaction. Getting the pyrano[2,3-c]pyrazole-3-carboxylate and pyrano[2,3-c]pyrazole compounds, a series of chemical explorations on the aminonitrile functionality was done by specifically focusing on the ring extension for different multicyclic compounds through C-C ring extension. Subsequent reaction pyranopyrazole imine with hydrazine and manganese chloride provided the pyranopyrimidine and its Novel complexes respectively. In total in this research more than 70 derivatives which some are novel compounds were generated. Multiple chemical analysis (1H and 13C NMR, CHNS, FTIR, EDX) were conducted to confirm the structure of all the synthesized compounds. 2020-11 Thesis https://ir.uitm.edu.my/id/eprint/59086/ https://ir.uitm.edu.my/id/eprint/59086/1/59086.pdf text en public masters Universiti Teknologi MARA Faculty of Applied Sciences Mohammat @ M Yahya, Mohd Fazli (Dr) Shaameri, Zurina (Dr.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohammat @ M Yahya, Mohd Fazli (Dr) Shaameri, Zurina (Dr.)
topic	Analytical chemistry
spellingShingle	Analytical chemistry Bouchamma, Fatima Ezzahra Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
description	A simple and green approach for the synthesis of fused pyrano[2,3-c]pyrazole-3-carboxylate and pyrano[2,3-c]pyrazole type compounds were developed.The main objective is to synthesize the Synthesis of novel derivatives of pyrano[2.3-c]pyrazole-imine and its derived manganese complexes analogues, in addition of the C-C ring extension of the pyranopyrazole for the new fused pyranopyrimidine and its derivatives. The synthesis of pyrano[2,3-c]pyrazole compounds was achieved via a domino one-pot, four-component reaction of diethyl oxaloacetate, hydrazine hydrate, aldehyde and malanonitrile in refluxing acidic ethanolic solution under non-catalytic system. This four-component reaction proceeds via sequential reactions of pyrazole synthesis, Michael addition and Thorpe-Ziegler cyclization reaction. Getting the pyrano[2,3-c]pyrazole-3-carboxylate and pyrano[2,3-c]pyrazole compounds, a series of chemical explorations on the aminonitrile functionality was done by specifically focusing on the ring extension for different multicyclic compounds through C-C ring extension. Subsequent reaction pyranopyrazole imine with hydrazine and manganese chloride provided the pyranopyrimidine and its Novel complexes respectively. In total in this research more than 70 derivatives which some are novel compounds were generated. Multiple chemical analysis (1H and 13C NMR, CHNS, FTIR, EDX) were conducted to confirm the structure of all the synthesized compounds.
format	Thesis
qualification_level	Master's degree
author	Bouchamma, Fatima Ezzahra
author_facet	Bouchamma, Fatima Ezzahra
author_sort	Bouchamma, Fatima Ezzahra
title	Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
title_short	Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
title_full	Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
title_fullStr	Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
title_full_unstemmed	Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra
title_sort	synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / bouchamma fatima ezzahra
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Sciences
publishDate	2020
url	https://ir.uitm.edu.my/id/eprint/59086/1/59086.pdf
_version_	1783735016421851136

Synthesis and chemical exploration of pyrano[2,3-c]pyrazole type compound / Bouchamma Fatima Ezzahra

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