A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff

Background. As the usage of certain conventional medications are becoming increasingly common among the current generation, their previously unexplored side effects and long-term effects have started to become a subject of scrutiny, and the link between these medications and long-term effects is sta...

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Main Author:	Md Shariff, Adibah
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Diabetes Mellitus
Online Access:	https://ir.uitm.edu.my/id/eprint/59681/1/59681.pdf
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spelling	my-uitm-ir.596812022-05-17T02:55:21Z A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff 2020-08 Md Shariff, Adibah Diabetes Mellitus Background. As the usage of certain conventional medications are becoming increasingly common among the current generation, their previously unexplored side effects and long-term effects have started to become a subject of scrutiny, and the link between these medications and long-term effects is starting to be explored. Recently, there has been a massive discovery in terms of the possible contribution of statins in the development of Type II Type II diabetes mellitus (T2DM). This discovery has led to many subsequent debates or uncertainties over the safety and necessity of statins. As the discovery of the relationship between statins and diabetes is still relatively new, there has yet to be extensive research exploring on the more specific details of the association. The individual risk of statin types has been explored but not extensively, among the Malaysian population. Objectives. To investigate the incidence of new-onset Type II diabetes mellitus and to compare the risk of development of new-onset Type II diabetes mellitus among different statin user cohorts in a Malaysian healthcare setting Research Design. This was a retrospective cohort study Methods. 507 patients without Type II diabetes mellitus who were given statin treatment in Hospital Sungai Buloh were retrospectively enrolled and subsequently divided into four cohorts according to the types of statin given. Results. The mean duration of this study was 32.5 months (±18.1) while the median duration was almost the same at 31.0 months (±26.3). The minimum duration of study was 2.9 months, while the maximum duration was 87.9 months. Between the three main cohorts, the incidence of T2DM was found to be highest in the simvastatin user group (20 of 114: 17.5%), followed by the mixed statin user group (35 of 213: 16.4%), and lastly the lovastatin group (28 of 172: 16.3%), p=0.956. As the p value was >0.05, it was found that there was no significant difference in the incidence of T2DM among the three statin user cohorts. Meanwhile, the risk of T2DM was found to be significantly higher in the lovastatin and simvastatin user groups compared to the mixed statin user group, with a hazard ratio of 1.88 (p=0.017) for lovastatin compared to the mixed statin user cohort, and a hazard ratio of 1.87 (p=0.029) for simvastatin compared to the mixed statin user cohort. Conclusions. The risk of new-onset T2DM from lovastatin alone or simvastatin alone was significantly greater than that of mixed statin users, in which the statin type was switched at least once throughout the study. The risk of new-onset T2DM posed by lovastatin and simvastatin was almost the same. There was no significant difference in the incidence of T2DM among the three statin user cohorts. 2020-08 Thesis https://ir.uitm.edu.my/id/eprint/59681/ https://ir.uitm.edu.my/id/eprint/59681/1/59681.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy Karuppannan, Mahmathi (Dr.) Gnanasan, Shubashini (Dr.) Abd Aziz, Noorizan (Prof.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Karuppannan, Mahmathi (Dr.) Gnanasan, Shubashini (Dr.) Abd Aziz, Noorizan (Prof.)
topic	Diabetes Mellitus
spellingShingle	Diabetes Mellitus Md Shariff, Adibah A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
description	Background. As the usage of certain conventional medications are becoming increasingly common among the current generation, their previously unexplored side effects and long-term effects have started to become a subject of scrutiny, and the link between these medications and long-term effects is starting to be explored. Recently, there has been a massive discovery in terms of the possible contribution of statins in the development of Type II Type II diabetes mellitus (T2DM). This discovery has led to many subsequent debates or uncertainties over the safety and necessity of statins. As the discovery of the relationship between statins and diabetes is still relatively new, there has yet to be extensive research exploring on the more specific details of the association. The individual risk of statin types has been explored but not extensively, among the Malaysian population. Objectives. To investigate the incidence of new-onset Type II diabetes mellitus and to compare the risk of development of new-onset Type II diabetes mellitus among different statin user cohorts in a Malaysian healthcare setting Research Design. This was a retrospective cohort study Methods. 507 patients without Type II diabetes mellitus who were given statin treatment in Hospital Sungai Buloh were retrospectively enrolled and subsequently divided into four cohorts according to the types of statin given. Results. The mean duration of this study was 32.5 months (±18.1) while the median duration was almost the same at 31.0 months (±26.3). The minimum duration of study was 2.9 months, while the maximum duration was 87.9 months. Between the three main cohorts, the incidence of T2DM was found to be highest in the simvastatin user group (20 of 114: 17.5%), followed by the mixed statin user group (35 of 213: 16.4%), and lastly the lovastatin group (28 of 172: 16.3%), p=0.956. As the p value was >0.05, it was found that there was no significant difference in the incidence of T2DM among the three statin user cohorts. Meanwhile, the risk of T2DM was found to be significantly higher in the lovastatin and simvastatin user groups compared to the mixed statin user group, with a hazard ratio of 1.88 (p=0.017) for lovastatin compared to the mixed statin user cohort, and a hazard ratio of 1.87 (p=0.029) for simvastatin compared to the mixed statin user cohort. Conclusions. The risk of new-onset T2DM from lovastatin alone or simvastatin alone was significantly greater than that of mixed statin users, in which the statin type was switched at least once throughout the study. The risk of new-onset T2DM posed by lovastatin and simvastatin was almost the same. There was no significant difference in the incidence of T2DM among the three statin user cohorts.
format	Thesis
qualification_level	Master's degree
author	Md Shariff, Adibah
author_facet	Md Shariff, Adibah
author_sort	Md Shariff, Adibah
title	A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
title_short	A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
title_full	A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
title_fullStr	A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
title_full_unstemmed	A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff
title_sort	comparison of the incidence and hazard ratio of type ii diabetes mellitus among statin user groups in a malaysian healthcare setting / adibah md shariff
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2020
url	https://ir.uitm.edu.my/id/eprint/59681/1/59681.pdf
_version_	1783735045988548608

A comparison of the incidence and hazard ratio of Type II diabetes mellitus among statin user groups in a Malaysian healthcare setting / Adibah Md Shariff

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