Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam

Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam

Synthesis, characterization and sustained release studies of ultraviolet (UV) absorber intercalated into layered metal hydroxides aims were to synthesize cinnamic acid into LDH by using co-precipitation method and intercalation of salicylic into LDH by anion exchange method. Co-precipitation (direct...

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Main Author: Adam, Nurain
Format: Thesis
Language:English
Published: 2021
Subjects:
Metal complexes
Layered double hydroxides
Online Access:https://ir.uitm.edu.my/id/eprint/59715/1/59715.pdf
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spelling my-uitm-ir.597152022-05-17T05:48:28Z Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam 2021-02 Adam, Nurain Metal complexes. Layered double hydroxides Synthesis, characterization and sustained release studies of ultraviolet (UV) absorber intercalated into layered metal hydroxides aims were to synthesize cinnamic acid into LDH by using co-precipitation method and intercalation of salicylic into LDH by anion exchange method. Co-precipitation (direct method) was used for encapsulation of salicylic and cinnamic acid between the galleries of Zinc Layered Hydroxide (ZLH). Various concentrations were used ranging from 0.03 M, 0.05 M, 0.07 M, 0.1M, 0.2 M, 0.25 M, 0.35 M, 0.4 M 0.6 M to 0.8 M for cinnamic acid (CA) and salicylic acid (SA) and the pH 7 ± 0.5 was kept constant throughout the synthesis process. Release behaviours were determined using 0.05 M sodium chloride (NaCl), sodium carbonate (Na2CO3) and sodium phosphate (Na3PO4) as aqueous media for 60000 minutes or until reach an equilibrium. The release profile was fitted into three types of kinetic models such as Zeroth Order, First Order and Pseudo-Second Order. The Powder X-Ray Diffraction (PXRD) data shows a well phase with high crystallinity of layered double hydroxide-cinnamic (LDCA), layered double hydroxide-salicylic (LDSA), zinc layered hydroxide-cinnamic (ZLCA) and zinc layered hydroxide-salicylic (ZLSA) intercalated compound. Increase in basal spacing from 9.0 Å of LDH-host to 17.7 Å for LDCA and 16.3 Å for LDSA. Disappearance of peak ranging between 2θ = 30º to 60º with presence of new peak at 24.4 Å for ZLCA and 16.15Å for ZLSA deduce successful intercalation. The results were supported with the data obtained from the whole analysis using FTIR ASAP, ICP-OES, FESEM, TGA-DTG, UV-Vis andCHNS.All the nanocompsoites that were synthesized observed to have Type IV which were mesoporous type material with calculated percentage loading of 23.57%, 24.40%, 40.07% and 35.35% for LDCA, LDSA, ZLCA and ZLSA respectively. Encapsulation of cinnamic acid and salicylic acid into the interlayer galleries of LDH and ZLH able to control the release of anion from its interlayer region. The data obtained from UV-Vis shows the release profile of cinnamic and salicylic acid were in the order of Na3PO4> Na2CO3> NaCl with percentage release of 89%, 63%, 43% for LDCA, 89%, 70%, 40% in LDSA, with 95%, 80%, 65% for ZLCA and 80%, 69%, 45% for ZLSA respectively.Pseudo-Second Order were the best kinetic model with R2> 0.8 explaining the release of cinnamic acid and salicylic acid from the LDH and ZLH interlayer region. This study shows that LDH and ZLH can be used as the matrix for the sustained release formulation ultraviolet absorber of trans-cinnamic acid and salicylic acid compound. 2021-02 Thesis https://ir.uitm.edu.my/id/eprint/59715/ https://ir.uitm.edu.my/id/eprint/59715/1/59715.pdf text en public masters Universiti Teknologi MARA Faculty of Applied Sciences Sheikh Mohd Ghazali, Sheikh Ahmad Izaddin (Ts. Dr. Tn.) Dzulkifli, Nur Nadia (Dr.)
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Sheikh Mohd Ghazali, Sheikh Ahmad Izaddin (Ts. Dr. Tn.)
Dzulkifli, Nur Nadia (Dr.)
topic Metal complexes
Layered double hydroxides
spellingShingle Metal complexes
Layered double hydroxides
Adam, Nurain
Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
description Synthesis, characterization and sustained release studies of ultraviolet (UV) absorber intercalated into layered metal hydroxides aims were to synthesize cinnamic acid into LDH by using co-precipitation method and intercalation of salicylic into LDH by anion exchange method. Co-precipitation (direct method) was used for encapsulation of salicylic and cinnamic acid between the galleries of Zinc Layered Hydroxide (ZLH). Various concentrations were used ranging from 0.03 M, 0.05 M, 0.07 M, 0.1M, 0.2 M, 0.25 M, 0.35 M, 0.4 M 0.6 M to 0.8 M for cinnamic acid (CA) and salicylic acid (SA) and the pH 7 ± 0.5 was kept constant throughout the synthesis process. Release behaviours were determined using 0.05 M sodium chloride (NaCl), sodium carbonate (Na2CO3) and sodium phosphate (Na3PO4) as aqueous media for 60000 minutes or until reach an equilibrium. The release profile was fitted into three types of kinetic models such as Zeroth Order, First Order and Pseudo-Second Order. The Powder X-Ray Diffraction (PXRD) data shows a well phase with high crystallinity of layered double hydroxide-cinnamic (LDCA), layered double hydroxide-salicylic (LDSA), zinc layered hydroxide-cinnamic (ZLCA) and zinc layered hydroxide-salicylic (ZLSA) intercalated compound. Increase in basal spacing from 9.0 Å of LDH-host to 17.7 Å for LDCA and 16.3 Å for LDSA. Disappearance of peak ranging between 2θ = 30º to 60º with presence of new peak at 24.4 Å for ZLCA and 16.15Å for ZLSA deduce successful intercalation. The results were supported with the data obtained from the whole analysis using FTIR ASAP, ICP-OES, FESEM, TGA-DTG, UV-Vis andCHNS.All the nanocompsoites that were synthesized observed to have Type IV which were mesoporous type material with calculated percentage loading of 23.57%, 24.40%, 40.07% and 35.35% for LDCA, LDSA, ZLCA and ZLSA respectively. Encapsulation of cinnamic acid and salicylic acid into the interlayer galleries of LDH and ZLH able to control the release of anion from its interlayer region. The data obtained from UV-Vis shows the release profile of cinnamic and salicylic acid were in the order of Na3PO4> Na2CO3> NaCl with percentage release of 89%, 63%, 43% for LDCA, 89%, 70%, 40% in LDSA, with 95%, 80%, 65% for ZLCA and 80%, 69%, 45% for ZLSA respectively.Pseudo-Second Order were the best kinetic model with R2> 0.8 explaining the release of cinnamic acid and salicylic acid from the LDH and ZLH interlayer region. This study shows that LDH and ZLH can be used as the matrix for the sustained release formulation ultraviolet absorber of trans-cinnamic acid and salicylic acid compound.
format Thesis
qualification_level Master's degree
author Adam, Nurain
author_facet Adam, Nurain
author_sort Adam, Nurain
title Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
title_short Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
title_full Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
title_fullStr Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
title_full_unstemmed Synthesis, characterization and sustained release studies of UV absorber intercalated into layered metal hydroxides / Nurain Adam
title_sort synthesis, characterization and sustained release studies of uv absorber intercalated into layered metal hydroxides / nurain adam
granting_institution Universiti Teknologi MARA
granting_department Faculty of Applied Sciences
publishDate 2021
url https://ir.uitm.edu.my/id/eprint/59715/1/59715.pdf
_version_ 1783735049484500992

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