Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin

Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin

A new emerging study shows that moderately boiled garlic enriched polysulphide-derived hydrogen sulphide (H2S). However, the dose-response effect of polysulphide-enriched garlic (PEG) on endogenous H2S production, and the therapeutic, ergogenic and physiological responses has yet to be explored. In...

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Main Author: Nordin, Ahmad Safwanudin
Format: Thesis
Language:English
Published: 2021
Subjects:
Sports Medicine
Online Access:https://ir.uitm.edu.my/id/eprint/60083/1/60083.pdf
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spelling my-uitm-ir.600832022-05-23T01:24:57Z Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin 2021-06 Nordin, Ahmad Safwanudin Sports Medicine A new emerging study shows that moderately boiled garlic enriched polysulphide-derived hydrogen sulphide (H2S). However, the dose-response effect of polysulphide-enriched garlic (PEG) on endogenous H2S production, and the therapeutic, ergogenic and physiological responses has yet to be explored. In a randomized, double-blind, placebo–controlled crossover design trial, 12 healthy men ingested 2 g, 4 g and 6 g of PEG or placebo (PLA) to establish the effects of PEG on systolic BP, diastolic BP and eH2S over 24-hr. Subsequently, 15 collegiate-level male completed high-intensity intermittent exercise tests, with optimal timing and dose of PEG informed from the preceding trial. Compared to PLA, systolic BP was lowered in a dose-dependent manner in 4 g and 6 PEG (p < 0.01), but not diastolic BP (p > 0.05). Similarly, eH2S was significantly elevated in the two of the highest dosages of PEG compared to PLA, with no additional increase in eH2S after ingesting 6 g compared with 4 g PEG (both p < 0.001) with peak changes (Δ) at 3 to 5 hours relative to baseline (p < 0.05). In the subsequent phase, following 5-day supplementation of 4 g PEG and PLA prior to 3 hours preceding the completion of a YYIRTL1. Resting eH2S was ~42% greater, while systolic BP and mean arterial pressure (MAP) was lower by ~2.6% in PEG compared to PLA (p < 0.05). Performance in the cognitive function test was ~3.81% and ~2.66% faster at rest and during YYIRTL1, respectively, with performance in YYIRTL1 only tended to increase in PEG compared to PLA (p = 0.08). Blood [glucose] and mean heart rate was lower during YYIRTL1 (p < 0.05), but no changes in blood [lactate]. Taken together, the present study suggests that PEG supplementation dose-dependently lower resting BP and may enhance cognitive function during high-intensity intermittent performance. 2021-06 Thesis https://ir.uitm.edu.my/id/eprint/60083/ https://ir.uitm.edu.my/id/eprint/60083/1/60083.pdf text en public masters Universiti Teknologi MARA Faculty of Sports Science and Recreation Linoby, Adam
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Linoby, Adam
topic Sports Medicine
spellingShingle Sports Medicine
Nordin, Ahmad Safwanudin
Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
description A new emerging study shows that moderately boiled garlic enriched polysulphide-derived hydrogen sulphide (H2S). However, the dose-response effect of polysulphide-enriched garlic (PEG) on endogenous H2S production, and the therapeutic, ergogenic and physiological responses has yet to be explored. In a randomized, double-blind, placebo–controlled crossover design trial, 12 healthy men ingested 2 g, 4 g and 6 g of PEG or placebo (PLA) to establish the effects of PEG on systolic BP, diastolic BP and eH2S over 24-hr. Subsequently, 15 collegiate-level male completed high-intensity intermittent exercise tests, with optimal timing and dose of PEG informed from the preceding trial. Compared to PLA, systolic BP was lowered in a dose-dependent manner in 4 g and 6 PEG (p < 0.01), but not diastolic BP (p > 0.05). Similarly, eH2S was significantly elevated in the two of the highest dosages of PEG compared to PLA, with no additional increase in eH2S after ingesting 6 g compared with 4 g PEG (both p < 0.001) with peak changes (Δ) at 3 to 5 hours relative to baseline (p < 0.05). In the subsequent phase, following 5-day supplementation of 4 g PEG and PLA prior to 3 hours preceding the completion of a YYIRTL1. Resting eH2S was ~42% greater, while systolic BP and mean arterial pressure (MAP) was lower by ~2.6% in PEG compared to PLA (p < 0.05). Performance in the cognitive function test was ~3.81% and ~2.66% faster at rest and during YYIRTL1, respectively, with performance in YYIRTL1 only tended to increase in PEG compared to PLA (p = 0.08). Blood [glucose] and mean heart rate was lower during YYIRTL1 (p < 0.05), but no changes in blood [lactate]. Taken together, the present study suggests that PEG supplementation dose-dependently lower resting BP and may enhance cognitive function during high-intensity intermittent performance.
format Thesis
qualification_level Master's degree
author Nordin, Ahmad Safwanudin
author_facet Nordin, Ahmad Safwanudin
author_sort Nordin, Ahmad Safwanudin
title Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
title_short Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
title_full Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
title_fullStr Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
title_full_unstemmed Polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / Ahmad Safwanudin Nordin
title_sort polysulphide-enriched garlic supplementation: dose-response relationships and physiological responses to high intensity intermittent exercise / ahmad safwanudin nordin
granting_institution Universiti Teknologi MARA
granting_department Faculty of Sports Science and Recreation
publishDate 2021
url https://ir.uitm.edu.my/id/eprint/60083/1/60083.pdf
_version_ 1783735081741844480

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