Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin

Tuberculosis (TB) among children remains a significant public health problem. The objectives of this study were to determine the determinants of TB treatment success among children and explore their parents’ perspectives on achieving successful treatment. A mixed-method study design was utilised wit...

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Main Author:	Awaluddin, S Maria
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Tuberculosis Diseases of children and adolescents
Online Access:	https://ir.uitm.edu.my/id/eprint/60143/1/60143.pdf
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id	my-uitm-ir.60143
record_format	uketd_dc
spelling	my-uitm-ir.601432022-05-23T07:40:57Z Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin 2021-06 Awaluddin, S Maria Tuberculosis Diseases of children and adolescents Tuberculosis (TB) among children remains a significant public health problem. The objectives of this study were to determine the determinants of TB treatment success among children and explore their parents’ perspectives on achieving successful treatment. A mixed-method study design was utilised with the main study focusing on quantitative analysis of secondary data from the MyTB database version 2.1 in phase one, followed by a sequential explanatory study via in-depth interview of 15 participants in the qualitative component in phase two. Data were analysed using Microsoft Excel and R software version 3.6.1, which also contained a package for qualitative data analysis. This study obtained ethical approval from the Universiti Teknologi MARA Research Ethics Committee and the Medical Research and Ethics Committee, Ministry of Health Malaysia. The quantitative study analysed 3550 registered children with TB disease in Malaysia from 2013 to 2017. The treatment success rate among children in Malaysia was 87.1% in 2013 and plateaued around 90.1% to 91.4% from 2014 until 2017. The determinants for TB treatment success were being Malaysian citizens (adjusted odds ratio [aOR] = 3.41; 95% confidence interval [CI] = 2.46, 4.72), being the children without HIV co-infection (aOR = 3.15; 95% CI = 1.55, 6.39), underwent treatment in public clinics (aOR = 2.64; 95% CI =1.72, 4.05) or private facilities (aOR = 2.07; 95% CI =1.04, 4.12), chest X-ray findings of no lesion (aOR = 2.15 ; 95% CI = 1.46, 3.16) or minimal lesions (aOR = 2.09; 95% CI = 1.57, 2.78). Children with BCG scars (aOR = 1.93; 95% CI = 1.39, 2.68) and being in older age group (aOR = 1.06; 95% CI = 1.03, 1.09) were also associated with TB treatment success. Children who were diagnosed with sputum-positive pulmonary TB (aOR = 0.58; 95% CI = 0.43, 0.79) or extrapulmonary TB (aOR = 0.58; 95% CI = 0.41, 0.82) were negatively associated with TB treatment success. The qualitative results identified four main themes; the evidence of having contracted TB disease, trust towards the healthcare services, motivation to take or continue treatment and multiple challenges. This study concludes that the treatment success is positively associated with children who were Malaysian citizens in the mild phase of TB disease. Targeted screening and intervention to the at-risk group and giving appropriate supports to the affected family are imperative in achieving TB treatment success among children. 2021-06 Thesis https://ir.uitm.edu.my/id/eprint/60143/ https://ir.uitm.edu.my/id/eprint/60143/1/60143.pdf text en public masters Universiti Teknologi MARA Faculty of Medicine Ismail, Nurhuda (Dr.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ismail, Nurhuda (Dr.)
topic	Tuberculosis Diseases of children and adolescents
spellingShingle	Tuberculosis Diseases of children and adolescents Awaluddin, S Maria Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
description	Tuberculosis (TB) among children remains a significant public health problem. The objectives of this study were to determine the determinants of TB treatment success among children and explore their parents’ perspectives on achieving successful treatment. A mixed-method study design was utilised with the main study focusing on quantitative analysis of secondary data from the MyTB database version 2.1 in phase one, followed by a sequential explanatory study via in-depth interview of 15 participants in the qualitative component in phase two. Data were analysed using Microsoft Excel and R software version 3.6.1, which also contained a package for qualitative data analysis. This study obtained ethical approval from the Universiti Teknologi MARA Research Ethics Committee and the Medical Research and Ethics Committee, Ministry of Health Malaysia. The quantitative study analysed 3550 registered children with TB disease in Malaysia from 2013 to 2017. The treatment success rate among children in Malaysia was 87.1% in 2013 and plateaued around 90.1% to 91.4% from 2014 until 2017. The determinants for TB treatment success were being Malaysian citizens (adjusted odds ratio [aOR] = 3.41; 95% confidence interval [CI] = 2.46, 4.72), being the children without HIV co-infection (aOR = 3.15; 95% CI = 1.55, 6.39), underwent treatment in public clinics (aOR = 2.64; 95% CI =1.72, 4.05) or private facilities (aOR = 2.07; 95% CI =1.04, 4.12), chest X-ray findings of no lesion (aOR = 2.15 ; 95% CI = 1.46, 3.16) or minimal lesions (aOR = 2.09; 95% CI = 1.57, 2.78). Children with BCG scars (aOR = 1.93; 95% CI = 1.39, 2.68) and being in older age group (aOR = 1.06; 95% CI = 1.03, 1.09) were also associated with TB treatment success. Children who were diagnosed with sputum-positive pulmonary TB (aOR = 0.58; 95% CI = 0.43, 0.79) or extrapulmonary TB (aOR = 0.58; 95% CI = 0.41, 0.82) were negatively associated with TB treatment success. The qualitative results identified four main themes; the evidence of having contracted TB disease, trust towards the healthcare services, motivation to take or continue treatment and multiple challenges. This study concludes that the treatment success is positively associated with children who were Malaysian citizens in the mild phase of TB disease. Targeted screening and intervention to the at-risk group and giving appropriate supports to the affected family are imperative in achieving TB treatment success among children.
format	Thesis
qualification_level	Master's degree
author	Awaluddin, S Maria
author_facet	Awaluddin, S Maria
author_sort	Awaluddin, S Maria
title	Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
title_short	Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
title_full	Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
title_fullStr	Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
title_full_unstemmed	Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin
title_sort	determinants of treatment success among children with tuberculosis using mytb database version 2.1 and their parents' perspectives on successful treatment / s maria awaluddin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2021
url	https://ir.uitm.edu.my/id/eprint/60143/1/60143.pdf
_version_	1783735089518084096

Determinants of treatment success among children with tuberculosis using MyTB database version 2.1 and their parents' perspectives on successful treatment / S Maria Awaluddin

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