The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat

The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat

A new study has shown that moderately boiled garlic can enhance polysulphides, a known potent donor of essential gasotransmitters (hydrogen sulphide, H2S and nitric oxide, NO) in humans. However, the dose response relationship of polysulphide-enhanced garlic (PEG) on exhaled gasotransmitter profiles...

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Main Author: Jumat, Muhammad Alif Nazrin
Format: Thesis
Language:English
Published: 2021
Subjects:
Exercise
Human physiology
Online Access:https://ir.uitm.edu.my/id/eprint/60151/1/60151.pdf
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spelling my-uitm-ir.601512022-05-23T08:03:19Z The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat 2021-06 Jumat, Muhammad Alif Nazrin Exercise Human physiology A new study has shown that moderately boiled garlic can enhance polysulphides, a known potent donor of essential gasotransmitters (hydrogen sulphide, H2S and nitric oxide, NO) in humans. However, the dose response relationship of polysulphide-enhanced garlic (PEG) on exhaled gasotransmitter profiles as well as the physiological responses to high-intensity constant load exercise tolerance have yet to be investigated. In a randomised, double-blinded, placebo–controlled crossover design trial, 12 healthy men ingested 2 g, 4 g and 6 g of PEG or placebo (PLA) to establish the effects of PEG on eH2S, FeNO and MAP over a 24-hour period. Subsequently, 12 collegiate-level male athletes completed high-intensity constant load exercise 3-hour after orally consuming 4 g of either PEG or PLA with a washout period of 14 days separating each trial. Compared to PLA, eH2S was significantly elevated during two of the highest dosages of PEG, with no additional increase after 6 g PEG ingestion compared to 4 g (both p < 0.001), however no changes in FeNO (p > 0.05). Additionally, MAP decreased in a dose-dependent manner for the highest dosage of 6 g PEG (p < 0.001), with peak changes (Δ) in MAP and eH2S occurred at 3 to 5 hours relative to the baseline (p < 0.05). A negative correlation has been observed between the changes in MAP and the changes in eH2S for PEG and PLA (r = -0.37, p < 0.001). In the subsequent phase, resting eH2S was ~49% greater, while the systolic BP and MAP were lower by ~3% and ~2% in PEG compared to PLA (p < 0.05), respectively. Although PEG did not significantly alter time-to-exhaustion in intense constant load exercise (p = 0.06), the results indicate substantial improvements (~6%) in 8 out of 12 participants. Blood [glucose] was lower during constant load exercise (p < 0.05) but no changes in blood [lactate]. The current study suggests that the dose-dependent PEG supplementation could lower several BP indices likely via enhanced bioavailability of H2S, but not NO. This study further demonstrates that short-term PEG supplementation (i.e., 4 g) could enhance high-intensity exercise tolerance, with the effects were highly variable between participants. 2021-06 Thesis https://ir.uitm.edu.my/id/eprint/60151/ https://ir.uitm.edu.my/id/eprint/60151/1/60151.pdf text en public masters Universiti Teknologi MARA Faculty of Sports Science and Recreation Linoby, Adam
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Linoby, Adam
topic Exercise
Human physiology
spellingShingle Exercise
Human physiology
Jumat, Muhammad Alif Nazrin
The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
description A new study has shown that moderately boiled garlic can enhance polysulphides, a known potent donor of essential gasotransmitters (hydrogen sulphide, H2S and nitric oxide, NO) in humans. However, the dose response relationship of polysulphide-enhanced garlic (PEG) on exhaled gasotransmitter profiles as well as the physiological responses to high-intensity constant load exercise tolerance have yet to be investigated. In a randomised, double-blinded, placebo–controlled crossover design trial, 12 healthy men ingested 2 g, 4 g and 6 g of PEG or placebo (PLA) to establish the effects of PEG on eH2S, FeNO and MAP over a 24-hour period. Subsequently, 12 collegiate-level male athletes completed high-intensity constant load exercise 3-hour after orally consuming 4 g of either PEG or PLA with a washout period of 14 days separating each trial. Compared to PLA, eH2S was significantly elevated during two of the highest dosages of PEG, with no additional increase after 6 g PEG ingestion compared to 4 g (both p < 0.001), however no changes in FeNO (p > 0.05). Additionally, MAP decreased in a dose-dependent manner for the highest dosage of 6 g PEG (p < 0.001), with peak changes (Δ) in MAP and eH2S occurred at 3 to 5 hours relative to the baseline (p < 0.05). A negative correlation has been observed between the changes in MAP and the changes in eH2S for PEG and PLA (r = -0.37, p < 0.001). In the subsequent phase, resting eH2S was ~49% greater, while the systolic BP and MAP were lower by ~3% and ~2% in PEG compared to PLA (p < 0.05), respectively. Although PEG did not significantly alter time-to-exhaustion in intense constant load exercise (p = 0.06), the results indicate substantial improvements (~6%) in 8 out of 12 participants. Blood [glucose] was lower during constant load exercise (p < 0.05) but no changes in blood [lactate]. The current study suggests that the dose-dependent PEG supplementation could lower several BP indices likely via enhanced bioavailability of H2S, but not NO. This study further demonstrates that short-term PEG supplementation (i.e., 4 g) could enhance high-intensity exercise tolerance, with the effects were highly variable between participants.
format Thesis
qualification_level Master's degree
author Jumat, Muhammad Alif Nazrin
author_facet Jumat, Muhammad Alif Nazrin
author_sort Jumat, Muhammad Alif Nazrin
title The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
title_short The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
title_full The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
title_fullStr The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
title_full_unstemmed The influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / Muhammad Alif Nazrin Jumat
title_sort influence of polysulphide-enhanced garlic intake on gasotransmitters profiles and selected physiological responses to high-intensity constant load exercise / muhammad alif nazrin jumat
granting_institution Universiti Teknologi MARA
granting_department Faculty of Sports Science and Recreation
publishDate 2021
url https://ir.uitm.edu.my/id/eprint/60151/1/60151.pdf
_version_ 1783735091297517568

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