Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar

Drug analysis on biological samples have been widely used in forensic toxicology. Samples of hair and nail offer several advantages in drug analysis such as longer time-window for drug detection. The objective of this study was to identify the presence of Amphetamine-Type Stimulants (ATS) drugs incl...

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Main Author:	Mokhtar, Nur Amirah
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Laboratories General works Analytical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/60459/1/60459.pdf
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id	my-uitm-ir.60459
record_format	uketd_dc
spelling	my-uitm-ir.604592022-05-30T00:26:35Z Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar 2021-09 Mokhtar, Nur Amirah Laboratories. General works Analytical chemistry Drug analysis on biological samples have been widely used in forensic toxicology. Samples of hair and nail offer several advantages in drug analysis such as longer time-window for drug detection. The objective of this study was to identify the presence of Amphetamine-Type Stimulants (ATS) drugs including amphetamine (AMP), methamphetamine (MAMP), N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), methylene-dioxyamphetamine (MDA), methylenedioxyethyl-amphetamine (MDEA), methylenedioxy-methamphetamine (MDMA) from hair and nail samples of drug abusers. In this work, 97 male drug abusers’ hair and 88 nail samples of ATS usage history were investigated. The identification of ATS in the samples was analysed by using alkaline digestion method with Gas Chromatography-Flame Ionization Detector (GC-FID). Both methods of hair and nail analysis were successfully analyzed and validated with the assessment of the following parameters: linearity of calibration curve, limit of detection (LOD) and limit of quantification (LOQ). The results revealed that analyte AMP is the highest most detected ATS drug in hair, followed by MAMP, MDEA, MBDB, MDA and MDMA. While for nail drug analysis, the highest content on ATS drug detected was analyte MDA, followed by AMP, MDEA, MBDB, MAMP and MDMA. This method of alkaline digestion was proven to be simple and was successfully applied for the quantification of ATS drug in hair and nail samples of drug abusers. 2021-09 Thesis https://ir.uitm.edu.my/id/eprint/60459/ https://ir.uitm.edu.my/id/eprint/60459/1/60459.pdf text en public masters Universiti Teknologi MARA Faculty of Applied Sciences Rajagopal, Kavitha (Dr.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Rajagopal, Kavitha (Dr.)
topic	Laboratories General works Analytical chemistry
spellingShingle	Laboratories General works Analytical chemistry Mokhtar, Nur Amirah Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
description	Drug analysis on biological samples have been widely used in forensic toxicology. Samples of hair and nail offer several advantages in drug analysis such as longer time-window for drug detection. The objective of this study was to identify the presence of Amphetamine-Type Stimulants (ATS) drugs including amphetamine (AMP), methamphetamine (MAMP), N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), methylene-dioxyamphetamine (MDA), methylenedioxyethyl-amphetamine (MDEA), methylenedioxy-methamphetamine (MDMA) from hair and nail samples of drug abusers. In this work, 97 male drug abusers’ hair and 88 nail samples of ATS usage history were investigated. The identification of ATS in the samples was analysed by using alkaline digestion method with Gas Chromatography-Flame Ionization Detector (GC-FID). Both methods of hair and nail analysis were successfully analyzed and validated with the assessment of the following parameters: linearity of calibration curve, limit of detection (LOD) and limit of quantification (LOQ). The results revealed that analyte AMP is the highest most detected ATS drug in hair, followed by MAMP, MDEA, MBDB, MDA and MDMA. While for nail drug analysis, the highest content on ATS drug detected was analyte MDA, followed by AMP, MDEA, MBDB, MAMP and MDMA. This method of alkaline digestion was proven to be simple and was successfully applied for the quantification of ATS drug in hair and nail samples of drug abusers.
format	Thesis
qualification_level	Master's degree
author	Mokhtar, Nur Amirah
author_facet	Mokhtar, Nur Amirah
author_sort	Mokhtar, Nur Amirah
title	Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
title_short	Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
title_full	Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
title_fullStr	Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
title_full_unstemmed	Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar
title_sort	analysis of amphetamine-type stimulants (ats) drug in hair and nail samples of drug abusers / nur amirah mokhtar
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Sciences
publishDate	2021
url	https://ir.uitm.edu.my/id/eprint/60459/1/60459.pdf
_version_	1783735129420595200

Analysis of amphetamine-type stimulants (ATS) drug in hair and nail samples of drug abusers / Nur Amirah Mokhtar

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