Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali

Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali

Dental panoramic tomogram (DPT) and lateral cephalogram (LC) are routinely taken to aid orthodontic diagnosis and treatment planning. The increasing needs for dental radiographs over the recent years has raised concern over the stochastic effects as this will predispose patients to radiation exposur...

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Main Author: Ghazali, Liyana
Format: Thesis
Language:English
Published: 2020
Subjects:
Orthodontics
Online Access:https://ir.uitm.edu.my/id/eprint/60823/1/60823.pdf
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spelling my-uitm-ir.608232022-06-02T08:28:53Z Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali 2020-09 Ghazali, Liyana Orthodontics Dental panoramic tomogram (DPT) and lateral cephalogram (LC) are routinely taken to aid orthodontic diagnosis and treatment planning. The increasing needs for dental radiographs over the recent years has raised concern over the stochastic effects as this will predispose patients to radiation exposure which may cause cell damage and increase the risk of developing oral carcinoma. Every radiograph machine has different parameters of tube potential (kV) and tube current (mA) depending on to its individual type and brand. In accordance to as low as possibly achievable (ALARA) principle, it is necessary to optimize radiation dose parameters as one of the ways to reduce the radiation exposure without compromising the quality and diagnostic performance of the images. The radiographic study of this trial was conducted to investigate the effect of reducing scanning parameters of DPTs and LCs on image quality and diagnostic performance by detection of anatomical landmarks. The cytotoxicity study was conducted to evaluate the effect of dental radiation on the exfoliative buccal mucosa cells. Sample size was calculated showed that 17 participants were required in the radiographic study and 7 were required in cytotoxicity study. 38 adult orthodontic patients were randomized into two groups; the control group received dose parameters as prescribed by the manufacturer by setting the machine in automatic mode and the intervention group received reduced dose parameters of DPT (60kV, 3.2mA) and LC (85kV, 8mA). Images were analysed for image quality and diagnostic performance. In another 20 patients following the same protocol as above, exfoliative buccal mucosa smears were taken before (T0) and after radiation exposures (T0). The presence of nuclear alterations was noted and compared. All data were analysed using Mann- Whitney Test. Results showed that there was no significant difference of score image quality for between control and intervention groups with p-values of 0.058 for DPT and 0.063 for LC. The same finding was also demonstrated for diagnostic performance of the DPT and LC with p=0.797 and 0.272, respectively. There was an increase in the presence of nuclear alterations of about 60% in both groups after the radiation exposure. However, there was no statistically significant difference in the presence of nuclear alterations was found between groups (p=0.603). In conclusion, orthodontic scanning parameters can be reduced by at least 30% without compromising image quality and diagnostic value of the images. Radiation from orthodontic scanning examinations might not produce chromosomal damage but can induce cytotoxic effects by increasing rate of nuclear alterations regardless of level of radiation. 2020-09 Thesis https://ir.uitm.edu.my/id/eprint/60823/ https://ir.uitm.edu.my/id/eprint/60823/1/60823.pdf text en public phd doctoral Universiti Teknologi MARA Faculty of Dentistry Hafizan Norman, Noraina (Dr.)
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Hafizan Norman, Noraina (Dr.)
topic Orthodontics
spellingShingle Orthodontics
Ghazali, Liyana
Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
description Dental panoramic tomogram (DPT) and lateral cephalogram (LC) are routinely taken to aid orthodontic diagnosis and treatment planning. The increasing needs for dental radiographs over the recent years has raised concern over the stochastic effects as this will predispose patients to radiation exposure which may cause cell damage and increase the risk of developing oral carcinoma. Every radiograph machine has different parameters of tube potential (kV) and tube current (mA) depending on to its individual type and brand. In accordance to as low as possibly achievable (ALARA) principle, it is necessary to optimize radiation dose parameters as one of the ways to reduce the radiation exposure without compromising the quality and diagnostic performance of the images. The radiographic study of this trial was conducted to investigate the effect of reducing scanning parameters of DPTs and LCs on image quality and diagnostic performance by detection of anatomical landmarks. The cytotoxicity study was conducted to evaluate the effect of dental radiation on the exfoliative buccal mucosa cells. Sample size was calculated showed that 17 participants were required in the radiographic study and 7 were required in cytotoxicity study. 38 adult orthodontic patients were randomized into two groups; the control group received dose parameters as prescribed by the manufacturer by setting the machine in automatic mode and the intervention group received reduced dose parameters of DPT (60kV, 3.2mA) and LC (85kV, 8mA). Images were analysed for image quality and diagnostic performance. In another 20 patients following the same protocol as above, exfoliative buccal mucosa smears were taken before (T0) and after radiation exposures (T0). The presence of nuclear alterations was noted and compared. All data were analysed using Mann- Whitney Test. Results showed that there was no significant difference of score image quality for between control and intervention groups with p-values of 0.058 for DPT and 0.063 for LC. The same finding was also demonstrated for diagnostic performance of the DPT and LC with p=0.797 and 0.272, respectively. There was an increase in the presence of nuclear alterations of about 60% in both groups after the radiation exposure. However, there was no statistically significant difference in the presence of nuclear alterations was found between groups (p=0.603). In conclusion, orthodontic scanning parameters can be reduced by at least 30% without compromising image quality and diagnostic value of the images. Radiation from orthodontic scanning examinations might not produce chromosomal damage but can induce cytotoxic effects by increasing rate of nuclear alterations regardless of level of radiation.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Ghazali, Liyana
author_facet Ghazali, Liyana
author_sort Ghazali, Liyana
title Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
title_short Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
title_full Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
title_fullStr Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
title_full_unstemmed Effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / Liyana Ghazali
title_sort effects of reducing orthodontic scanning parameters on image quality and cytotoxicity of nuclei: a randomized controlled clinical trial / liyana ghazali
granting_institution Universiti Teknologi MARA
granting_department Faculty of Dentistry
publishDate 2020
url https://ir.uitm.edu.my/id/eprint/60823/1/60823.pdf
_version_ 1783735177060548608

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