Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin

Metabolic syndrome (MS) represents a cluster of risk factors consisting of central obesity, atherogenic dyslipidaemia, hypertension and insulin resistant which increases coronary heart disease risk. Central obesity was postulated to be the underlying mechanism of metabolic syndrome. This present stu...

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Main Author:	Saimin, Hanis
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Diseases of the endocrine glands Clinical endocrinology Diabetes Mellitus
Online Access:	https://ir.uitm.edu.my/id/eprint/61966/1/61966.pdf
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id	my-uitm-ir.61966
record_format	uketd_dc
spelling	my-uitm-ir.619662022-06-24T01:09:20Z Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin 2016-08 Saimin, Hanis Diseases of the endocrine glands. Clinical endocrinology Diabetes Mellitus Metabolic syndrome (MS) represents a cluster of risk factors consisting of central obesity, atherogenic dyslipidaemia, hypertension and insulin resistant which increases coronary heart disease risk. Central obesity was postulated to be the underlying mechanism of metabolic syndrome. This present study aims to determine the relationship between coronary risk biomarkers, abdominal fat volume indices and carotid intima-media thickness (IMT) in drug naïve MS, central obesity without MS (COBXMS) and normal lean controls (NC), and between MS glycaemic subgroups. A cross sectional study involving 498 subjects (163 males and 355 females, age (mean±SD): 47.4±8.3 years) categorized into MS, COBXMS and NC. MS subjects were subdivided according to glycaemic status: diabetes mellitus (MDSM), impaired fasting glucose (MSIFG) and normoglycaemic (MSNG). Both MS and COBXMS had lower adiponectin and higher coronary risk biomarkers, abdominal fat volume indices and carotid IMT compared to NC; but these biomarkers were similar between MS and COBXMS. Similarly, MS glycaemic subgroups showed no differences (p>0.05) in these biomarkers. Waist circumference, blood pressure and subcutaneous fat volume were the independent variables affecting coronary risk biomarkers in all subjects after correcting for the various confounding factors. Among the MS glycaemic subgroups, waist circumference and blood pressure remained to be the independent variable. Central obesity without MS has reduced atheroprotective adipokine and enhanced prothrombotic and inflammation status comparable to MS, suggesting increased coronary risk in centrally obese subjects even in the absence of metabolic syndrome. 2016-08 Thesis https://ir.uitm.edu.my/id/eprint/61966/ https://ir.uitm.edu.my/id/eprint/61966/1/61966.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Mohd Nawawi, Hapizah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohd Nawawi, Hapizah
topic	Diseases of the endocrine glands Clinical endocrinology Diabetes Mellitus
spellingShingle	Diseases of the endocrine glands Clinical endocrinology Diabetes Mellitus Saimin, Hanis Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
description	Metabolic syndrome (MS) represents a cluster of risk factors consisting of central obesity, atherogenic dyslipidaemia, hypertension and insulin resistant which increases coronary heart disease risk. Central obesity was postulated to be the underlying mechanism of metabolic syndrome. This present study aims to determine the relationship between coronary risk biomarkers, abdominal fat volume indices and carotid intima-media thickness (IMT) in drug naïve MS, central obesity without MS (COBXMS) and normal lean controls (NC), and between MS glycaemic subgroups. A cross sectional study involving 498 subjects (163 males and 355 females, age (mean±SD): 47.4±8.3 years) categorized into MS, COBXMS and NC. MS subjects were subdivided according to glycaemic status: diabetes mellitus (MDSM), impaired fasting glucose (MSIFG) and normoglycaemic (MSNG). Both MS and COBXMS had lower adiponectin and higher coronary risk biomarkers, abdominal fat volume indices and carotid IMT compared to NC; but these biomarkers were similar between MS and COBXMS. Similarly, MS glycaemic subgroups showed no differences (p>0.05) in these biomarkers. Waist circumference, blood pressure and subcutaneous fat volume were the independent variables affecting coronary risk biomarkers in all subjects after correcting for the various confounding factors. Among the MS glycaemic subgroups, waist circumference and blood pressure remained to be the independent variable. Central obesity without MS has reduced atheroprotective adipokine and enhanced prothrombotic and inflammation status comparable to MS, suggesting increased coronary risk in centrally obese subjects even in the absence of metabolic syndrome.
format	Thesis
qualification_level	Master's degree
author	Saimin, Hanis
author_facet	Saimin, Hanis
author_sort	Saimin, Hanis
title	Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
title_short	Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
title_full	Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
title_fullStr	Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
title_full_unstemmed	Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin
title_sort	coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / hanis saimin
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/61966/1/61966.pdf
_version_	1783735242567188480

Coronary risk biomarkers in centrally obese subjects with and without metabolic syndrome / Hanis Saimin

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