Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar

Background; Endocrine abnormalities in the form of adrenal, thyroid and gonadal abnormalities have been reported amongst patients with HIV in both early and advanced stages of the disease. These abnormalities may be manifested as subtle biochemical changes or overt glandular failure, affecting muscl...

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Main Author:	Ahmad Akbar, Rosdina Zamrud
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Toxicology Poisons
Online Access:	https://ir.uitm.edu.my/id/eprint/63352/1/63352.pdf
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id	my-uitm-ir.63352
record_format	uketd_dc
spelling	my-uitm-ir.633522022-07-04T05:38:33Z Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar 2018-10 Ahmad Akbar, Rosdina Zamrud Toxicology. Poisons AIDS. HIV infections Diseases of the endocrine glands. Clinical endocrinology Diseases of the genitourinary system. Urology Background; Endocrine abnormalities in the form of adrenal, thyroid and gonadal abnormalities have been reported amongst patients with HIV in both early and advanced stages of the disease. These abnormalities may be manifested as subtle biochemical changes or overt glandular failure, affecting muscle mass, sexual function, fat distribution and quality of life. This study aimed to determine the prevalence and associated factors of hormonal abnormalities in HIV-infected patients. Objectives: To determine the prevalence and associated factors of thyroid, adrenal and gonadal dysfunction among HIV-infected patients. Methods: Single centre cross sectional study which involved 150 HIV- positive cases recruited by convenient sampling. Each subject was required to answer specific symptoms questionnaire and their medical records were reviewed for relevant clinical and biochemical data. Blood for thyroid function test, cortisol, ACTH, FSH, LH, testosterone and estradiol were collected and estimated by the electrochemiluminescent immunoassay. Hormone abnormalities were identified as thyroid, adrenal and gonadal axes abnormalities and their correlation with possible associated factors were analyzed. Results: The highest prevalence of hormonal abnormality was hypogonadism which was detected in 23 patients (15.3%), followed by thyroid dysfunction in 18 patients (12%) and hypocortisolism in only 2 patients (1.3%). There was significant correlation between CD4 count, BMI and age with the hormone level. Conclusion: Prevalence of hormone abnormalities are low among HIV-infected patient in the present study. Although not common, there were significant correlation between CD4 count, age and BMI with hormone level. 2018-10 Thesis https://ir.uitm.edu.my/id/eprint/63352/ https://ir.uitm.edu.my/id/eprint/63352/1/63352.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Abdul Ghani, AP Rohana
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Ghani, AP Rohana
topic	Toxicology Poisons Toxicology Poisons Toxicology Poisons Toxicology Poisons
spellingShingle	Toxicology Poisons Toxicology Poisons Toxicology Poisons Toxicology Poisons Ahmad Akbar, Rosdina Zamrud Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
description	Background; Endocrine abnormalities in the form of adrenal, thyroid and gonadal abnormalities have been reported amongst patients with HIV in both early and advanced stages of the disease. These abnormalities may be manifested as subtle biochemical changes or overt glandular failure, affecting muscle mass, sexual function, fat distribution and quality of life. This study aimed to determine the prevalence and associated factors of hormonal abnormalities in HIV-infected patients. Objectives: To determine the prevalence and associated factors of thyroid, adrenal and gonadal dysfunction among HIV-infected patients. Methods: Single centre cross sectional study which involved 150 HIV- positive cases recruited by convenient sampling. Each subject was required to answer specific symptoms questionnaire and their medical records were reviewed for relevant clinical and biochemical data. Blood for thyroid function test, cortisol, ACTH, FSH, LH, testosterone and estradiol were collected and estimated by the electrochemiluminescent immunoassay. Hormone abnormalities were identified as thyroid, adrenal and gonadal axes abnormalities and their correlation with possible associated factors were analyzed. Results: The highest prevalence of hormonal abnormality was hypogonadism which was detected in 23 patients (15.3%), followed by thyroid dysfunction in 18 patients (12%) and hypocortisolism in only 2 patients (1.3%). There was significant correlation between CD4 count, BMI and age with the hormone level. Conclusion: Prevalence of hormone abnormalities are low among HIV-infected patient in the present study. Although not common, there were significant correlation between CD4 count, age and BMI with hormone level.
format	Thesis
qualification_level	Master's degree
author	Ahmad Akbar, Rosdina Zamrud
author_facet	Ahmad Akbar, Rosdina Zamrud
author_sort	Ahmad Akbar, Rosdina Zamrud
title	Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
title_short	Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
title_full	Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
title_fullStr	Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
title_full_unstemmed	Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar
title_sort	endocrinopathies in hiv infected patients / rosdina zamrud ahmad akbar
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2018
url	https://ir.uitm.edu.my/id/eprint/63352/1/63352.pdf
_version_	1783735319291494400

Endocrinopathies in HIV infected patients / Rosdina Zamrud Ahmad Akbar

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