The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri

Introduction: Obstructive sleep apnoea (OSA) has been closely associated with nonalcoholic fatty liver disease (NAFLD). It also increases cardiovascular risk and metabolic syndrome. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. Thus, this st...

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Main Author:	Sukahri, Samshol
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Diseases of the circulatory (Cardiovascular) system
Online Access:	https://ir.uitm.edu.my/id/eprint/63388/1/63388.pdf
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id	my-uitm-ir.63388
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spelling	my-uitm-ir.633882022-07-05T01:04:20Z The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri 2018-10 Sukahri, Samshol Diseases of the circulatory (Cardiovascular) system Diseases of the digestive system. Gastroenterology Introduction: Obstructive sleep apnoea (OSA) has been closely associated with nonalcoholic fatty liver disease (NAFLD). It also increases cardiovascular risk and metabolic syndrome. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. Thus, this study aimed to determine the relationships between severity of OSA and degree of steatosis and cardiovascular risk via CIMT measurements in a group of OSA patients. Methods: This was a cross-sectional study, conducted at the Faculty of Medicine Uitm. We screened 110 subjects between 18 to 65 years of age, who were diagnosed OSA following sleep study examinations. We excluded patients with seropositive Hepatitis B or Hepatitis C, and significant alcohol intake. Result: The prevalence of NAFLD was 81.8% (n= 90). Almost half of them had NAFLD Stage 1 42.7% (n= 47), 32% (n= 42) had Stage 2 and 1 had Stage 3 (0.9%).The subjects with NAFLD had significantly higher weight compared to those without NAFLD (94.77 kg ± 21.85 vs 74.67 kg ± 16.80, p < 0.001). There were statistically significantly higher mean systolic blood pressure, waist circumference, hip circumference, waist hip ratio and severity of OSA (AHI) among the NAFLD and vs the non NAFLD groups. The mean ICAM-1, Lp(a) and CIMT were significantly higher in the NAFLD group compared to the non-NAFLD group (334.53 ng/mL ± 72.86 vs 265.46 ng/mL ± 102.92, p = 0.001, 85.41 nmol/L ± 52.56 vs 23.55 nmol/L ± 23.66, p <0.001, 0.08 cm ± 0.03 vs 0.06 cm ± 0.01, p = 0.001) respectively. Comparisons between the non-NAFLD, NAFLD 1 and NAFLD 2 groups showed significant differences in systolic blood pressure, diastolic blood pressure, BMI, waist circumference, ICAM-1 and Lp(a) indicating higher cardiovascular risks in the latter 2 groups. Similarly, patients with severe AHI had significantly higher systolic blood pressure, diastolic blood pressure, and waist circumference compared to those with mild AHI and moderate AHI. However, there were no statistically significant differences in mean CIMT values between these 3 groups (mild AHI, moderate AHI and severe AHI, respectively: 0.07 cm ± 0.02 vs 0.08 cm ± 0.03 vs 0.08 cm ± 0.02, p = 0.250). The correlation between stages of NAFLD and the severity of OSA (AHI) was significant by using the Chi-square with p < 0.001 and r = 0.453. Conclusion: This study suggested that the prevalence of NAFLD is alarmingly high in the OSA population. The degree of steatosis in patients with NAFLD was significantly correlated with severity of OSA, CIMT measurements, ICAM-1 and Lp(a). ICAM-1 and Lp(a) are the strong predictors for NAFLD in OSA patients. These findings underscore the significant atherosclerotic risks of these patients and further emphasises the need for a comprehensive cardiovascular risk assessment in this group of high risk patients. 2018-10 Thesis https://ir.uitm.edu.my/id/eprint/63388/ https://ir.uitm.edu.my/id/eprint/63388/1/63388.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Mohamad Shah, Fatimah Zaherah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohamad Shah, Fatimah Zaherah
topic	Diseases of the circulatory (Cardiovascular) system Diseases of the circulatory (Cardiovascular) system
spellingShingle	Diseases of the circulatory (Cardiovascular) system Diseases of the circulatory (Cardiovascular) system Sukahri, Samshol The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
description	Introduction: Obstructive sleep apnoea (OSA) has been closely associated with nonalcoholic fatty liver disease (NAFLD). It also increases cardiovascular risk and metabolic syndrome. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. Thus, this study aimed to determine the relationships between severity of OSA and degree of steatosis and cardiovascular risk via CIMT measurements in a group of OSA patients. Methods: This was a cross-sectional study, conducted at the Faculty of Medicine Uitm. We screened 110 subjects between 18 to 65 years of age, who were diagnosed OSA following sleep study examinations. We excluded patients with seropositive Hepatitis B or Hepatitis C, and significant alcohol intake. Result: The prevalence of NAFLD was 81.8% (n= 90). Almost half of them had NAFLD Stage 1 42.7% (n= 47), 32% (n= 42) had Stage 2 and 1 had Stage 3 (0.9%).The subjects with NAFLD had significantly higher weight compared to those without NAFLD (94.77 kg ± 21.85 vs 74.67 kg ± 16.80, p < 0.001). There were statistically significantly higher mean systolic blood pressure, waist circumference, hip circumference, waist hip ratio and severity of OSA (AHI) among the NAFLD and vs the non NAFLD groups. The mean ICAM-1, Lp(a) and CIMT were significantly higher in the NAFLD group compared to the non-NAFLD group (334.53 ng/mL ± 72.86 vs 265.46 ng/mL ± 102.92, p = 0.001, 85.41 nmol/L ± 52.56 vs 23.55 nmol/L ± 23.66, p <0.001, 0.08 cm ± 0.03 vs 0.06 cm ± 0.01, p = 0.001) respectively. Comparisons between the non-NAFLD, NAFLD 1 and NAFLD 2 groups showed significant differences in systolic blood pressure, diastolic blood pressure, BMI, waist circumference, ICAM-1 and Lp(a) indicating higher cardiovascular risks in the latter 2 groups. Similarly, patients with severe AHI had significantly higher systolic blood pressure, diastolic blood pressure, and waist circumference compared to those with mild AHI and moderate AHI. However, there were no statistically significant differences in mean CIMT values between these 3 groups (mild AHI, moderate AHI and severe AHI, respectively: 0.07 cm ± 0.02 vs 0.08 cm ± 0.03 vs 0.08 cm ± 0.02, p = 0.250). The correlation between stages of NAFLD and the severity of OSA (AHI) was significant by using the Chi-square with p < 0.001 and r = 0.453. Conclusion: This study suggested that the prevalence of NAFLD is alarmingly high in the OSA population. The degree of steatosis in patients with NAFLD was significantly correlated with severity of OSA, CIMT measurements, ICAM-1 and Lp(a). ICAM-1 and Lp(a) are the strong predictors for NAFLD in OSA patients. These findings underscore the significant atherosclerotic risks of these patients and further emphasises the need for a comprehensive cardiovascular risk assessment in this group of high risk patients.
format	Thesis
qualification_level	Master's degree
author	Sukahri, Samshol
author_facet	Sukahri, Samshol
author_sort	Sukahri, Samshol
title	The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
title_short	The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
title_full	The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
title_fullStr	The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
title_full_unstemmed	The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri
title_sort	association between severity of liver steatosis, apnoea and atherosclerosis risk in osa patients with nafld / samshol sukahri
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2018
url	https://ir.uitm.edu.my/id/eprint/63388/1/63388.pdf
_version_	1783735322298810368

The association between severity of liver steatosis, apnoea and atherosclerosis risk in OSA patients with NAFLD / Samshol Sukahri

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