Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah

More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protei...

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Main Author:	Pindah, Winddy
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical technology Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf
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id	my-uitm-ir.63802
record_format	uketd_dc
spelling	my-uitm-ir.638022022-07-28T10:44:09Z Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah 2012-07 Pindah, Winddy Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical technology Pharmaceutical chemistry More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protein-protein interactions (PPIs). Knowledge of PPIs promising new approach to discover drug by targeting the undruggable fragment based. However, to facilitate this task is not easy as their estimation due to the biophysical properties of membrane protein. There are several study have been done to improve PPIs identification in membrane protein, among the solution is incorporating various biologically meaningful data such as network topological features, protein primary sequences and structures. Thus, the objectives of this study are to design an integrated heterogeneous database of membrane protein from Protein Data Bank (PDB), Protein Topology Graph Library (PTGL) and Universal Protein Resource (Uniprot) and to use data from an integrated heterogeneous database of membrane protein resources for membrane proteinprotein interactions (PPIs) identification. Most of information gathered on this study obtained from interview and review to previous related study. This study aims to contribute to development and improvement of technology or tools to study membrane proteins as the important resource for drug target, in order to improve or develop novel pharmacological drug targets. 2012-07 Thesis https://ir.uitm.edu.my/id/eprint/63802/ https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf text en public masters Universiti Teknologi MARA Faculty of Computer and Mathematical Sciences Nordin, Sharifalillah (Dr.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Nordin, Sharifalillah (Dr.)
topic	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical technology Pharmaceutical chemistry
spellingShingle	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical technology Pharmaceutical chemistry Pindah, Winddy Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
description	More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protein-protein interactions (PPIs). Knowledge of PPIs promising new approach to discover drug by targeting the undruggable fragment based. However, to facilitate this task is not easy as their estimation due to the biophysical properties of membrane protein. There are several study have been done to improve PPIs identification in membrane protein, among the solution is incorporating various biologically meaningful data such as network topological features, protein primary sequences and structures. Thus, the objectives of this study are to design an integrated heterogeneous database of membrane protein from Protein Data Bank (PDB), Protein Topology Graph Library (PTGL) and Universal Protein Resource (Uniprot) and to use data from an integrated heterogeneous database of membrane protein resources for membrane proteinprotein interactions (PPIs) identification. Most of information gathered on this study obtained from interview and review to previous related study. This study aims to contribute to development and improvement of technology or tools to study membrane proteins as the important resource for drug target, in order to improve or develop novel pharmacological drug targets.
format	Thesis
qualification_level	Master's degree
author	Pindah, Winddy
author_facet	Pindah, Winddy
author_sort	Pindah, Winddy
title	Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_short	Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_full	Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_fullStr	Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_full_unstemmed	Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_sort	integrated heterogeneous database of membrane protein for protein-protein interactions (ppis) identification / winddy pindah
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Computer and Mathematical Sciences
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf
_version_	1783735349474754560

Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah

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