Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah

Background: Employment is one of the important components of rehabilitation among patients with schizophrenia that promotes functional recovery. Patients demonstrate impairment in various cognitive domains, particularly in working memory, executive function and processing speed. It was proposed that...

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Main Author:	Hasbollah, Nurul Nadia
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Medical personnel and the public Physician and the public Psychoses
Online Access:	https://ir.uitm.edu.my/id/eprint/63810/1/63810.pdf
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id	my-uitm-ir.63810
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spelling	my-uitm-ir.638102023-03-17T09:07:37Z Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah 2019 Hasbollah, Nurul Nadia Medical personnel and the public. Physician and the public Psychoses Background: Employment is one of the important components of rehabilitation among patients with schizophrenia that promotes functional recovery. Patients demonstrate impairment in various cognitive domains, particularly in working memory, executive function and processing speed. It was proposed that employment may have beneficial impact on working memory, executive function and processing speed. Objective: This study aimed to determine the level of working memory, executive function and processing speed and their associated employment as well as sociodemographic and clinical factors of patients with schizophrenia in supported employment program in Hospital Permai. Methodology: This is a cross-sectional study involving 118 patients with schizophrenia who were enrolled in Hospital Permai’s supported employment program. Those who fulfilled the inclusion criteria and gave informed consent were recruited. Sociodemographic, employment and clinical data were obtained from an interview with the patient and from the clinical notes. The diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview (M.I.N.I). The level of working memory was assessed using Weschler Memory Scale Third edition -Letter-Number Span and Spatial Span, the executive function was assessed using Neuropsychological Assessment Battery (NAB)- Mazes and the processing speed was measured using Brief Assessment of Cognition in Schizophrenia (BACS) – Category Fluency, Symbol Coding and Trail Making Test: Part A. Then, the findings of these tests were entered into MATRICS Consensus Cognitive Battery (MCCB) Scoring Program and the T score for the domain was generated. Results: From bivariate analysis, factors found to be associated with working memory were being married (p=0.032), successful employment (p<0.001) and good past work history (p=0.002), while factors found to be associated with executive function were successful employment (p=0.014), good past work history (p=0.003), typical antipsychotic (p=0.037) and good adherence to medication (p=0.027). Younger age and male gender were found to be associated with processing speed (p=0.014 and p=0.045 respectively). From multivariate analysis, significant predictors of working memory were successful employment (OR: 12.498; 95% CI: 2.552-61.206; p=0.002) and good past work history (OR: 3.356; 95% CI: 1.053-10.700; p=0.041), while significant predictors of executive function were successful employment (OR: 4.496; 95% CI: 1.106-18.280; p=0.036), good past work history (OR: 3.321; 95% CI: 1.028-10.727; p=0.045) and good adherence to medication (OR: 8.235; 95% CI: 1.478-45.867; p=0.016). Conclusion: Successful employment and good past work history were significant predictors for working memory and executive function. In addition, good adherence to medication was a significant contributing factor for executive function. 2019 Thesis https://ir.uitm.edu.my/id/eprint/63810/ https://ir.uitm.edu.my/id/eprint/63810/1/63810.pdf text en public masters Universiti Teknologi MARA, Selangor Faculty of Medicine Shuib, Norley Razali, Salmi
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Shuib, Norley Razali, Salmi
topic	Medical personnel and the public Physician and the public Psychoses
spellingShingle	Medical personnel and the public Physician and the public Psychoses Hasbollah, Nurul Nadia Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
description	Background: Employment is one of the important components of rehabilitation among patients with schizophrenia that promotes functional recovery. Patients demonstrate impairment in various cognitive domains, particularly in working memory, executive function and processing speed. It was proposed that employment may have beneficial impact on working memory, executive function and processing speed. Objective: This study aimed to determine the level of working memory, executive function and processing speed and their associated employment as well as sociodemographic and clinical factors of patients with schizophrenia in supported employment program in Hospital Permai. Methodology: This is a cross-sectional study involving 118 patients with schizophrenia who were enrolled in Hospital Permai’s supported employment program. Those who fulfilled the inclusion criteria and gave informed consent were recruited. Sociodemographic, employment and clinical data were obtained from an interview with the patient and from the clinical notes. The diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview (M.I.N.I). The level of working memory was assessed using Weschler Memory Scale Third edition -Letter-Number Span and Spatial Span, the executive function was assessed using Neuropsychological Assessment Battery (NAB)- Mazes and the processing speed was measured using Brief Assessment of Cognition in Schizophrenia (BACS) – Category Fluency, Symbol Coding and Trail Making Test: Part A. Then, the findings of these tests were entered into MATRICS Consensus Cognitive Battery (MCCB) Scoring Program and the T score for the domain was generated. Results: From bivariate analysis, factors found to be associated with working memory were being married (p=0.032), successful employment (p<0.001) and good past work history (p=0.002), while factors found to be associated with executive function were successful employment (p=0.014), good past work history (p=0.003), typical antipsychotic (p=0.037) and good adherence to medication (p=0.027). Younger age and male gender were found to be associated with processing speed (p=0.014 and p=0.045 respectively). From multivariate analysis, significant predictors of working memory were successful employment (OR: 12.498; 95% CI: 2.552-61.206; p=0.002) and good past work history (OR: 3.356; 95% CI: 1.053-10.700; p=0.041), while significant predictors of executive function were successful employment (OR: 4.496; 95% CI: 1.106-18.280; p=0.036), good past work history (OR: 3.321; 95% CI: 1.028-10.727; p=0.045) and good adherence to medication (OR: 8.235; 95% CI: 1.478-45.867; p=0.016). Conclusion: Successful employment and good past work history were significant predictors for working memory and executive function. In addition, good adherence to medication was a significant contributing factor for executive function.
format	Thesis
qualification_level	Master's degree
author	Hasbollah, Nurul Nadia
author_facet	Hasbollah, Nurul Nadia
author_sort	Hasbollah, Nurul Nadia
title	Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
title_short	Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
title_full	Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
title_fullStr	Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
title_full_unstemmed	Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah
title_sort	working memory, executive function and processing speed of patients with schizophrenia in supported employment program in hospital permai / nurul nadia hasbollah
granting_institution	Universiti Teknologi MARA, Selangor
granting_department	Faculty of Medicine
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/63810/1/63810.pdf
_version_	1783735350238117888

Working memory, executive function and processing speed of patients with schizophrenia in supported employment program in Hospital Permai / Nurul Nadia Hasbollah

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