The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar

Background and Aims: NAFLD and metabolic syndrome have been shown to have a synergistic impact on the development of atherosclerosis. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. The relationships between glycaemic control and degree of ste...

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Main Author:	Omar, Nurazam
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Metabolic diseases Diabetes Mellitus
Online Access:	https://ir.uitm.edu.my/id/eprint/64418/1/64418.PDF
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id	my-uitm-ir.64418
record_format	uketd_dc
spelling	my-uitm-ir.644182022-08-08T00:47:33Z The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar 2016-05 Omar, Nurazam Metabolic diseases Diabetes Mellitus Background and Aims: NAFLD and metabolic syndrome have been shown to have a synergistic impact on the development of atherosclerosis. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. The relationships between glycaemic control and degree of steatosis with CIMT in patients with NAFLD remain vague. Thus, this study aimed to determine the prevalence of NAFLD and the associated factors including CIMT among a high risk population of type 2 diabetes mellitus (T2DM) with established coronary artery disease (CAD). Materials and Methods. This is a cross-sectional study involving Type 2 DM patients between 18 to 65 years old who had established CAD based on coronary angiogram, dobutamine stress echocardiogram or exercise stress test (n=150). Patients with seropositive Hepatitis B or Hepatitis C, and significant alcohol intake were excluded. Baseline blood investigations were performed. All participants underwent ultrasonography of the abdomen by 2 independent radiologists for diagnosis of fatty liver, and further graded into moderate (NAFLD-2), mild (NAFLD-1) and no steatosis (non-NAFLD). B-mode ultrasonography of both common carotid arteries was also performed, with calculation of the average posterior wall intima media thickness of the right and left common carotid arteries to determine CIMT. 2016-05 Thesis https://ir.uitm.edu.my/id/eprint/64418/ https://ir.uitm.edu.my/id/eprint/64418/1/64418.PDF text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Abdul Ghani, Rohana
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Ghani, Rohana
topic	Metabolic diseases Diabetes Mellitus
spellingShingle	Metabolic diseases Diabetes Mellitus Omar, Nurazam The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
description	Background and Aims: NAFLD and metabolic syndrome have been shown to have a synergistic impact on the development of atherosclerosis. Carotid intima-media thickness (CIMT) is widely used as a reliable index of subclinical atherosclerosis. The relationships between glycaemic control and degree of steatosis with CIMT in patients with NAFLD remain vague. Thus, this study aimed to determine the prevalence of NAFLD and the associated factors including CIMT among a high risk population of type 2 diabetes mellitus (T2DM) with established coronary artery disease (CAD). Materials and Methods. This is a cross-sectional study involving Type 2 DM patients between 18 to 65 years old who had established CAD based on coronary angiogram, dobutamine stress echocardiogram or exercise stress test (n=150). Patients with seropositive Hepatitis B or Hepatitis C, and significant alcohol intake were excluded. Baseline blood investigations were performed. All participants underwent ultrasonography of the abdomen by 2 independent radiologists for diagnosis of fatty liver, and further graded into moderate (NAFLD-2), mild (NAFLD-1) and no steatosis (non-NAFLD). B-mode ultrasonography of both common carotid arteries was also performed, with calculation of the average posterior wall intima media thickness of the right and left common carotid arteries to determine CIMT.
format	Thesis
qualification_level	Master's degree
author	Omar, Nurazam
author_facet	Omar, Nurazam
author_sort	Omar, Nurazam
title	The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
title_short	The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
title_full	The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
title_fullStr	The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
title_full_unstemmed	The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar
title_sort	association between non-alcoholic fatty liver disease (nafld) and carotid-intima media thickness (cimt) in type 2 diabetes mellitus and proven coronary artery disease patients / nurazam omar
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/64418/1/64418.PDF
_version_	1783735457618591744

The association between non-alcoholic fatty liver disease (NAFLD) and carotid-intima media thickness (CIMT) in type 2 diabetes mellitus and proven coronary artery disease patients / Nurazam Omar

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