Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan

Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan

Microbial transformation or biotransformation is the modification in certain compounds using living organism such as bacterial or fungi. The main objective of present study is to investigate transformed metabolites, produced during fermentation of 17α-ethinyl steroids. Tibolone is a 17α-ethinyl ster...

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Main Author: A Azman Tan, Aminuddin
Format: Thesis
Language:English
Published: 2012
Subjects:
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/65535/1/65535.pdf
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spelling my-uitm-ir.655352022-08-22T04:51:13Z Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan 2012 A Azman Tan, Aminuddin Pharmaceutical chemistry Microbial transformation or biotransformation is the modification in certain compounds using living organism such as bacterial or fungi. The main objective of present study is to investigate transformed metabolites, produced during fermentation of 17α-ethinyl steroids. Tibolone is a 17α-ethinyl steroids, was chosen as the starting compound. Two fungi, Tricothecium roseum and Seaweed fungus have been used for fermentation studies. The transformed products were analyzed by using Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC). Isolation of metabolite were carried through Column Chromatography. Isolated metabolite was characterize through Nuclear Magnetic Resonance (NMR) Spectroscopy and LC-MS. Based on spectral data, the transformed metabolite was identified as 7-methyl-17-ethynl-17-hydroxy-19-norandrost-4-en-3-one. 2012 Thesis https://ir.uitm.edu.my/id/eprint/65535/ https://ir.uitm.edu.my/id/eprint/65535/1/65535.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Ali Shah, Syed Adnan
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Ali Shah, Syed Adnan
topic Pharmaceutical chemistry
spellingShingle Pharmaceutical chemistry
A Azman Tan, Aminuddin
Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
description Microbial transformation or biotransformation is the modification in certain compounds using living organism such as bacterial or fungi. The main objective of present study is to investigate transformed metabolites, produced during fermentation of 17α-ethinyl steroids. Tibolone is a 17α-ethinyl steroids, was chosen as the starting compound. Two fungi, Tricothecium roseum and Seaweed fungus have been used for fermentation studies. The transformed products were analyzed by using Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC). Isolation of metabolite were carried through Column Chromatography. Isolated metabolite was characterize through Nuclear Magnetic Resonance (NMR) Spectroscopy and LC-MS. Based on spectral data, the transformed metabolite was identified as 7-methyl-17-ethynl-17-hydroxy-19-norandrost-4-en-3-one.
format Thesis
qualification_level Bachelor degree
author A Azman Tan, Aminuddin
author_facet A Azman Tan, Aminuddin
author_sort A Azman Tan, Aminuddin
title Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
title_short Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
title_full Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
title_fullStr Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
title_full_unstemmed Microbial transformation of 17α-ethinyl steroids / Aminuddin A Azman Tan
title_sort microbial transformation of 17α-ethinyl steroids / aminuddin a azman tan
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Pharmacy
publishDate 2012
url https://ir.uitm.edu.my/id/eprint/65535/1/65535.pdf
_version_ 1783735554927493120

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