Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa

Banana is originated from the Musaceae family that highly produced in the tropical and subtropical regions of the world especially in Asia. Banana soft pith (BSP) is located inside the core of banana stem that fibrous in texture. Recently studies showed BSP were rich in nutrients and chemical compou...

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Main Author:	Musa, Mohd Fahmi
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Research Experimentation
Online Access:	https://ir.uitm.edu.my/id/eprint/65556/1/65556.pdf
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id	my-uitm-ir.65556
record_format	uketd_dc
spelling	my-uitm-ir.655562022-08-23T02:09:31Z Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa 2012 Musa, Mohd Fahmi Research. Experimentation Banana is originated from the Musaceae family that highly produced in the tropical and subtropical regions of the world especially in Asia. Banana soft pith (BSP) is located inside the core of banana stem that fibrous in texture. Recently studies showed BSP were rich in nutrients and chemical compounds such as protein, fat, fibre, lignin, cellulose. BSP also high contents of antioxidant properties such as flavanoids and polyphenols. This study is focusing on the screening of antiproliferative effect of BSP aqueous extract against the HCT116 and MCF7 cell lines by using the MTT assay to observe the IC50 at different period of treatment (24,48 and 72 hour). The results showed, IC50 for HCT116 after 72 hours treatment was 220μg/ml while IC50 for MCF7 after 72 hours treatment was 260μg/ml. Lowest IC50 on HCT116 than MCF7 shows BSP extracts showed good antiproliferative effect towards HCT cell lines. In conclusion the study has showed almost similar cytotoxic effect against both cells in time and concentration dependant manner. Recommendation for further studies about the mode of cell death and phytochemical properties that exhibit the cytotoxic effects of BSP aqueous extract. 2012 Thesis https://ir.uitm.edu.my/id/eprint/65556/ https://ir.uitm.edu.my/id/eprint/65556/1/65556.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Abdul Hamid, Hisyam
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Hamid, Hisyam
topic	Research Experimentation
spellingShingle	Research Experimentation Musa, Mohd Fahmi Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
description	Banana is originated from the Musaceae family that highly produced in the tropical and subtropical regions of the world especially in Asia. Banana soft pith (BSP) is located inside the core of banana stem that fibrous in texture. Recently studies showed BSP were rich in nutrients and chemical compounds such as protein, fat, fibre, lignin, cellulose. BSP also high contents of antioxidant properties such as flavanoids and polyphenols. This study is focusing on the screening of antiproliferative effect of BSP aqueous extract against the HCT116 and MCF7 cell lines by using the MTT assay to observe the IC50 at different period of treatment (24,48 and 72 hour). The results showed, IC50 for HCT116 after 72 hours treatment was 220μg/ml while IC50 for MCF7 after 72 hours treatment was 260μg/ml. Lowest IC50 on HCT116 than MCF7 shows BSP extracts showed good antiproliferative effect towards HCT cell lines. In conclusion the study has showed almost similar cytotoxic effect against both cells in time and concentration dependant manner. Recommendation for further studies about the mode of cell death and phytochemical properties that exhibit the cytotoxic effects of BSP aqueous extract.
format	Thesis
qualification_level	Bachelor degree
author	Musa, Mohd Fahmi
author_facet	Musa, Mohd Fahmi
author_sort	Musa, Mohd Fahmi
title	Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
title_short	Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
title_full	Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
title_fullStr	Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
title_full_unstemmed	Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa
title_sort	cytotoxicity study of banana soft pith (musa acuminata) towards colorectal (hct116) and breast cancer (mcf7) cell lines / mohd fahmi musa
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/65556/1/65556.pdf
_version_	1783735558182273024

Cytotoxicity study of banana soft pith (Musa acuminata) towards colorectal (HCT116) and breast cancer (MCF7) cell lines / Mohd Fahmi Musa

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