Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim

The present study deals with the solubility enhancement of Naproxen by adopting the combined use of surfactant and co-solvent. The solubility studies revealed 436.39 fold enhancements in the solvent system containing 0.8% w/v of sodium dodecyl sulphate and 8%v/v ethanol. The free energy of transfer...

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Main Author:	Abd Rahim, Nurul Nadiah
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Conditions and laws of chemical reactions Anti-inflammatory agents (General or not elsewhere classified)
Online Access:	https://ir.uitm.edu.my/id/eprint/65573/1/65573.pdf
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id	my-uitm-ir.65573
record_format	uketd_dc
spelling	my-uitm-ir.655732022-08-23T03:51:20Z Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim 2012 Abd Rahim, Nurul Nadiah Conditions and laws of chemical reactions Anti-inflammatory agents (General or not elsewhere classified) The present study deals with the solubility enhancement of Naproxen by adopting the combined use of surfactant and co-solvent. The solubility studies revealed 436.39 fold enhancements in the solvent system containing 0.8% w/v of sodium dodecyl sulphate and 8%v/v ethanol. The free energy of transfer for the solubilization process has been calculated. The samples of the solubility study were further subjected to conductometric analysis. The conductivity data was further analyzed and the thermodynamic parameters were duly calculated. The enhancement of solubility was correlated with the thermodynamic parameters to elucidate the molecular processes in terms of solute solvent interaction. 2012 Thesis https://ir.uitm.edu.my/id/eprint/65573/ https://ir.uitm.edu.my/id/eprint/65573/1/65573.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Tripathy, Minaketan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Tripathy, Minaketan
topic	Conditions and laws of chemical reactions Anti-inflammatory agents (General or not elsewhere classified)
spellingShingle	Conditions and laws of chemical reactions Anti-inflammatory agents (General or not elsewhere classified) Abd Rahim, Nurul Nadiah Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
description	The present study deals with the solubility enhancement of Naproxen by adopting the combined use of surfactant and co-solvent. The solubility studies revealed 436.39 fold enhancements in the solvent system containing 0.8% w/v of sodium dodecyl sulphate and 8%v/v ethanol. The free energy of transfer for the solubilization process has been calculated. The samples of the solubility study were further subjected to conductometric analysis. The conductivity data was further analyzed and the thermodynamic parameters were duly calculated. The enhancement of solubility was correlated with the thermodynamic parameters to elucidate the molecular processes in terms of solute solvent interaction.
format	Thesis
qualification_level	Bachelor degree
author	Abd Rahim, Nurul Nadiah
author_facet	Abd Rahim, Nurul Nadiah
author_sort	Abd Rahim, Nurul Nadiah
title	Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
title_short	Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
title_full	Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
title_fullStr	Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
title_full_unstemmed	Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim
title_sort	thermodynamics and solute solvent interactions during solubility enhancement of naproxen utilizing the combined use of cosolvent and surfactant / nurul nadiah abd rahim
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/65573/1/65573.pdf
_version_	1783735561360506880

Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim

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