Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi

Manufacturing a stable pharmaceutical product such as suspension is important so that the product would be able to exert its therapeutic advantages upon its use. Therefore, stability study is crucial in determining the stability of certain product. Suspension usually subjected to instability such as...

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Main Author:	Wan Muhammad Afifi, Wan Najihah
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/65625/1/65625.pdf
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id	my-uitm-ir.65625
record_format	uketd_dc
spelling	my-uitm-ir.656252022-11-07T07:42:31Z Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi 2012 Wan Muhammad Afifi, Wan Najihah Drugs and their actions Manufacturing a stable pharmaceutical product such as suspension is important so that the product would be able to exert its therapeutic advantages upon its use. Therefore, stability study is crucial in determining the stability of certain product. Suspension usually subjected to instability such as sedimentation. The sedimentation usually depends on several factors such as particle size of drug, viscosity of the dispersion medium and the storage temperature which had been studied in this research. To determine the stability of the suspension, several tests had been conducted such as particle size determination, polydispersibility index, zeta potential, viscosity, sedimentation rate and redispersability rate test. From these tests, it had been found that the larger particle size of the drug and low viscosity of dispersion medium would produce unstable suspension. Besides, the higher temperature of storage would also cause instability of the suspension. The unstable suspension would have higher sedimentation rate which was hard to be redispersed as hard ‘cake’ had formed. 2012 Thesis https://ir.uitm.edu.my/id/eprint/65625/ https://ir.uitm.edu.my/id/eprint/65625/1/65625.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Bustami Effendi, Tommy Julianto
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Bustami Effendi, Tommy Julianto
topic	Drugs and their actions
spellingShingle	Drugs and their actions Wan Muhammad Afifi, Wan Najihah Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
description	Manufacturing a stable pharmaceutical product such as suspension is important so that the product would be able to exert its therapeutic advantages upon its use. Therefore, stability study is crucial in determining the stability of certain product. Suspension usually subjected to instability such as sedimentation. The sedimentation usually depends on several factors such as particle size of drug, viscosity of the dispersion medium and the storage temperature which had been studied in this research. To determine the stability of the suspension, several tests had been conducted such as particle size determination, polydispersibility index, zeta potential, viscosity, sedimentation rate and redispersability rate test. From these tests, it had been found that the larger particle size of the drug and low viscosity of dispersion medium would produce unstable suspension. Besides, the higher temperature of storage would also cause instability of the suspension. The unstable suspension would have higher sedimentation rate which was hard to be redispersed as hard ‘cake’ had formed.
format	Thesis
qualification_level	Bachelor degree
author	Wan Muhammad Afifi, Wan Najihah
author_facet	Wan Muhammad Afifi, Wan Najihah
author_sort	Wan Muhammad Afifi, Wan Najihah
title	Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
title_short	Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
title_full	Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
title_fullStr	Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
title_full_unstemmed	Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi
title_sort	study on stability of paracetamol suspension with various thickening agents / wan najihah wan muhammad afifi
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/65625/1/65625.pdf
_version_	1783735563324489728

Study on stability of paracetamol suspension with various thickening agents / Wan Najihah Wan Muhammad Afifi

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