Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz

The use of herbal medicine is expanding at a surprising pace due to the great inputs from ethno medicinal practices being pooled from all over the world. The objective of this study is to provide information on the inhibitory effect of Malaysian traditional herb on CYP2D6 isozymes. The hypothesis is...

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Main Author:	Aziz, Ernyliza
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Herbs Herbal teas
Online Access:	https://ir.uitm.edu.my/id/eprint/66677/1/66677.pdf
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id	my-uitm-ir.66677
record_format	uketd_dc
spelling	my-uitm-ir.666772022-09-14T03:51:27Z Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz 2012 Aziz, Ernyliza Herbs. Herbal teas The use of herbal medicine is expanding at a surprising pace due to the great inputs from ethno medicinal practices being pooled from all over the world. The objective of this study is to provide information on the inhibitory effect of Malaysian traditional herb on CYP2D6 isozymes. The hypothesis is that the inhibition of herb on CYP2D6 enzymes will affect the metabolism CYP2D6 metabolizing drug and hence, there is herb-drug interaction. The Vivid ® CYP450 2D6 Screening Kits, were used to assess the inhibition effect of 18 Malaysian herbs on the human cytochrome P450 involved in hepatic metabolism. The test compounds were prepared in concentration of 0.1 and 1 mg/ml. Quinidine was used as the positive control. 18 herbs were tested for their inhibition on the CYP2D6 isozymes and all the 18 herbs showed inhibition in the concentration of 1 mg/ml while only 10 herbs showed inhibition with a concentration of 0.1 mg/ml. At 1mg/ml, kayu lilit showed the highest percentage of inhibition of more than 100% while sembaranthu showed the lowest percentage of inhibition with 30.3 ± 0.3 %. At a lower concentration of 0.1mg/ml, kayu lilit again showed the highest inhibition percentage of 77.3 ± 0.3 % and the lowest percentage inhibition was shown by senduduk with 0.7 ± 0.5 %. In conclusion, there is interaction between herbs and CYP2D6 isozymes which can affect the metabolism of drug that are metabolised by CYP2D6 isozymes if there were given simultaneously. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66677/ https://ir.uitm.edu.my/id/eprint/66677/1/66677.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Choo, Chee Yan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Choo, Chee Yan
topic	Herbs Herbal teas
spellingShingle	Herbs Herbal teas Aziz, Ernyliza Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
description	The use of herbal medicine is expanding at a surprising pace due to the great inputs from ethno medicinal practices being pooled from all over the world. The objective of this study is to provide information on the inhibitory effect of Malaysian traditional herb on CYP2D6 isozymes. The hypothesis is that the inhibition of herb on CYP2D6 enzymes will affect the metabolism CYP2D6 metabolizing drug and hence, there is herb-drug interaction. The Vivid ® CYP450 2D6 Screening Kits, were used to assess the inhibition effect of 18 Malaysian herbs on the human cytochrome P450 involved in hepatic metabolism. The test compounds were prepared in concentration of 0.1 and 1 mg/ml. Quinidine was used as the positive control. 18 herbs were tested for their inhibition on the CYP2D6 isozymes and all the 18 herbs showed inhibition in the concentration of 1 mg/ml while only 10 herbs showed inhibition with a concentration of 0.1 mg/ml. At 1mg/ml, kayu lilit showed the highest percentage of inhibition of more than 100% while sembaranthu showed the lowest percentage of inhibition with 30.3 ± 0.3 %. At a lower concentration of 0.1mg/ml, kayu lilit again showed the highest inhibition percentage of 77.3 ± 0.3 % and the lowest percentage inhibition was shown by senduduk with 0.7 ± 0.5 %. In conclusion, there is interaction between herbs and CYP2D6 isozymes which can affect the metabolism of drug that are metabolised by CYP2D6 isozymes if there were given simultaneously.
format	Thesis
qualification_level	Bachelor degree
author	Aziz, Ernyliza
author_facet	Aziz, Ernyliza
author_sort	Aziz, Ernyliza
title	Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
title_short	Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
title_full	Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
title_fullStr	Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
title_full_unstemmed	Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz
title_sort	malaysian traditional herbs: inhibition of malaysian traditional herbs on cyp2d6 isozymes / ernyliza aziz
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/66677/1/66677.pdf
_version_	1783735630273970176

Malaysian traditional herbs: inhibition of Malaysian traditional herbs on CYP2D6 isozymes / Ernyliza Aziz

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