Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom

The purpose of this study was to study the effectiveness of pharmacokinetics monitoring and to establish a population pharmacokinetics in pediatric hospitalized patients. The data comprise of 34 patients; 23 of male patients and 11 of female patients. The TDM data that had been collected from these...

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Main Author:	Shadom, Nordiyana
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RJ Pediatrics Materia medica and pharmacology
Online Access:	https://ir.uitm.edu.my/id/eprint/66742/1/66742.pdf
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id	my-uitm-ir.66742
record_format	uketd_dc
spelling	my-uitm-ir.667422022-09-15T00:24:16Z Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom 2012 Shadom, Nordiyana RJ Pediatrics Materia medica and pharmacology The purpose of this study was to study the effectiveness of pharmacokinetics monitoring and to establish a population pharmacokinetics in pediatric hospitalized patients. The data comprise of 34 patients; 23 of male patients and 11 of female patients. The TDM data that had been collected from these patients is 71 data. The patients had been divided into 3 group according to their age which is group 1 (6 months to 2 years), group 2 (2 years t0 5 years) and group 3 (5 years to 12 years). The patient parameters including body weight, gender, age, creatinine clearance (ClCr) and serum electrolytes were analyzed to identify their potential influences on gentamicin pharmacokinetics. The data was best described with a one-compartment model. The data analysis showed that there is a strong relationship between Ke and volume of distribution (Vd) with R2 value of 0.98, weight and clearance with R2 value of 0.99, and relationship between creatinine clearance (CrCl) and clearance of drug with R2 value is 0.917. The mean of Ke, t1/2 and Vd in this study, were 0.18 hour-1, 4.31 hour and 0.54 L respectively. This analysis indicates that this population has a wide inter-patient variability and it necessitate the practice of routine therapeutic drug monitoring to ensure minimal adverse effect and maximum therapeutic effect to the patients. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66742/ https://ir.uitm.edu.my/id/eprint/66742/1/66742.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Manan, Mohamed Mansor
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Manan, Mohamed Mansor
topic	RJ Pediatrics Materia medica and pharmacology
spellingShingle	RJ Pediatrics Materia medica and pharmacology Shadom, Nordiyana Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
description	The purpose of this study was to study the effectiveness of pharmacokinetics monitoring and to establish a population pharmacokinetics in pediatric hospitalized patients. The data comprise of 34 patients; 23 of male patients and 11 of female patients. The TDM data that had been collected from these patients is 71 data. The patients had been divided into 3 group according to their age which is group 1 (6 months to 2 years), group 2 (2 years t0 5 years) and group 3 (5 years to 12 years). The patient parameters including body weight, gender, age, creatinine clearance (ClCr) and serum electrolytes were analyzed to identify their potential influences on gentamicin pharmacokinetics. The data was best described with a one-compartment model. The data analysis showed that there is a strong relationship between Ke and volume of distribution (Vd) with R2 value of 0.98, weight and clearance with R2 value of 0.99, and relationship between creatinine clearance (CrCl) and clearance of drug with R2 value is 0.917. The mean of Ke, t1/2 and Vd in this study, were 0.18 hour-1, 4.31 hour and 0.54 L respectively. This analysis indicates that this population has a wide inter-patient variability and it necessitate the practice of routine therapeutic drug monitoring to ensure minimal adverse effect and maximum therapeutic effect to the patients.
format	Thesis
qualification_level	Bachelor degree
author	Shadom, Nordiyana
author_facet	Shadom, Nordiyana
author_sort	Shadom, Nordiyana
title	Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
title_short	Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
title_full	Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
title_fullStr	Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
title_full_unstemmed	Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom
title_sort	pharmacokinetics of gentamicin in pediatrics hospitalized patients / nordiyana shadom
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/66742/1/66742.pdf
_version_	1783735636262387712

Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom

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