The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali
In the present study, the effect of single-dose of subcutaneous injection administration of ivermectin on biochemical parameters of laboratory mouse has been analyzed and compared with normal (control) animals. The histological structure of kidney and liver of laboratory mouse was also examined. All...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/66812/1/66812.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-uitm-ir.66812 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-uitm-ir.668122022-09-15T07:30:47Z The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali 2012 Ghazali, Nurul Fauzaniy Diseases due to parasites Drugs and their actions In the present study, the effect of single-dose of subcutaneous injection administration of ivermectin on biochemical parameters of laboratory mouse has been analyzed and compared with normal (control) animals. The histological structure of kidney and liver of laboratory mouse was also examined. All 60 mice with average weight of 30g were divided into 10 groups where 5 groups were treatment groups and the other 5 groups were control groups. Ectoparasites identification was done on Day-1. Blood samples and organ collections from one control group and one treatment group were obtained on Day-2, Day-7, Day-14, Day-21 and Day-28. Ivermectin was found to be safe in laboratory mouse as the results obtained from the Mann-Whitney U test in biochemical parameters (ALT, AST, Creatinine and Urea), p-values were greater than 0.05. For the histological study, kidney and liver of the laboratory mouse showed no significant changes in control and treatment groups. However, further research is desired to study the long term effect of ivermectin. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66812/ https://ir.uitm.edu.my/id/eprint/66812/1/66812.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Shia, John Kwong Siew |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Shia, John Kwong Siew |
| topic |
Diseases due to parasites Drugs and their actions |
| spellingShingle |
Diseases due to parasites Drugs and their actions Ghazali, Nurul Fauzaniy The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| description |
In the present study, the effect of single-dose of subcutaneous injection administration of ivermectin on biochemical parameters of laboratory mouse has been analyzed and compared with normal (control) animals. The histological structure of kidney and liver of laboratory mouse was also examined. All 60 mice with average weight of 30g were divided into 10 groups where 5 groups were treatment groups and the other 5 groups
were control groups. Ectoparasites identification was done on Day-1. Blood samples and organ collections from one control group and one treatment group were obtained on Day-2, Day-7, Day-14, Day-21 and Day-28. Ivermectin was found to be safe in laboratory mouse as the results obtained from the Mann-Whitney U test in biochemical parameters (ALT, AST, Creatinine and Urea), p-values were greater than 0.05. For the histological study, kidney and liver of the laboratory mouse showed no significant changes in control and treatment groups. However, further research is desired to study the long term effect of ivermectin. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Ghazali, Nurul Fauzaniy |
| author_facet |
Ghazali, Nurul Fauzaniy |
| author_sort |
Ghazali, Nurul Fauzaniy |
| title |
The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| title_short |
The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| title_full |
The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| title_fullStr |
The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| title_full_unstemmed |
The effects of ivermectin on biochemical profile and histological analysis of laboratory mice / Nurul Fauzaniy Ghazali |
| title_sort |
effects of ivermectin on biochemical profile and histological analysis of laboratory mice / nurul fauzaniy ghazali |
| granting_institution |
Universiti Teknologi MARA (UiTM) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2012 |
| url |
https://ir.uitm.edu.my/id/eprint/66812/1/66812.pdf |
| _version_ |
1783735640818450432 |