Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan

Chemotherapy has become the common treatment choice in treating cancer even it can caused undesired side effect towards the patient as well as the health care handler. Thus, a lot of studies has been conducted to discover new and more selective anticancer. Plants are one of the most potential source...

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Main Author:	Wan Hassan, Wan Izzati Mariah
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Research Experimentation Chemotherapy Cytotoxic drugs
Online Access:	https://ir.uitm.edu.my/id/eprint/66821/1/66821.pdf
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id	my-uitm-ir.66821
record_format	uketd_dc
spelling	my-uitm-ir.668212022-09-15T08:12:34Z Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan 2012 Wan Hassan, Wan Izzati Mariah Research. Experimentation Chemotherapy Cytotoxic drugs Herbs. Herbal teas Chemotherapy has become the common treatment choice in treating cancer even it can caused undesired side effect towards the patient as well as the health care handler. Thus, a lot of studies has been conducted to discover new and more selective anticancer. Plants are one of the most potential sources in finding anticancer. Numerous drugs are marketed as anticancer drugs, hence plant have been known as a familiar sources for development of new anticancer. The present study was carried out to determine the cytotoxicity and selectivity of plant-derived compounds myricetin and mahanimbine against human glioma cell lines (U251) and human normal cell line (WRL68). Both compounds were tested for cytotoxicity against U251 and WRL68 cell lines by using the MTT assay. The IC50 of both compounds were derived from the dose-response curve. In this study, both of the compounds exhibited strong cytotoxic activity against U251 with IC50 of 2.52μg/ml and 3.98μg/ml respectively. Thus, compound, myricetin and mahanimbine were found to be potent against WRL68 as well, with IC50 of 2.91μg/ml and 4.03μg/ml respectively. Thus, advance studies to be needed in modifying the chemical structures of both compounds in order to reduce its toxicity towards normal cell but at the same time maintaining the effectiveness as good cytotoxic agents. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66821/ https://ir.uitm.edu.my/id/eprint/66821/1/66821.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Ramasamy, Kalavathy Mohd Nor Hazalin, Nurul Aqmar
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramasamy, Kalavathy Mohd Nor Hazalin, Nurul Aqmar
topic	Research Experimentation Chemotherapy Cytotoxic drugs Research Experimentation
spellingShingle	Research Experimentation Chemotherapy Cytotoxic drugs Research Experimentation Wan Hassan, Wan Izzati Mariah Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
description	Chemotherapy has become the common treatment choice in treating cancer even it can caused undesired side effect towards the patient as well as the health care handler. Thus, a lot of studies has been conducted to discover new and more selective anticancer. Plants are one of the most potential sources in finding anticancer. Numerous drugs are marketed as anticancer drugs, hence plant have been known as a familiar sources for development of new anticancer. The present study was carried out to determine the cytotoxicity and selectivity of plant-derived compounds myricetin and mahanimbine against human glioma cell lines (U251) and human normal cell line (WRL68). Both compounds were tested for cytotoxicity against U251 and WRL68 cell lines by using the MTT assay. The IC50 of both compounds were derived from the dose-response curve. In this study, both of the compounds exhibited strong cytotoxic activity against U251 with IC50 of 2.52μg/ml and 3.98μg/ml respectively. Thus, compound, myricetin and mahanimbine were found to be potent against WRL68 as well, with IC50 of 2.91μg/ml and 4.03μg/ml respectively. Thus, advance studies to be needed in modifying the chemical structures of both compounds in order to reduce its toxicity towards normal cell but at the same time maintaining the effectiveness as good cytotoxic agents.
format	Thesis
qualification_level	Bachelor degree
author	Wan Hassan, Wan Izzati Mariah
author_facet	Wan Hassan, Wan Izzati Mariah
author_sort	Wan Hassan, Wan Izzati Mariah
title	Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
title_short	Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
title_full	Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
title_fullStr	Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
title_full_unstemmed	Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan
title_sort	cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (u251) and a normal cell line (wrl68) / wan izzati mariah wan hassan
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/66821/1/66821.pdf
_version_	1783735643037237248

Cytotoxic activity of myricetin and mahanimbine against a brain cancer cell line (U251) and a normal cell line (WRL68) / Wan Izzati Mariah Wan Hassan

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