Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah

The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spont...

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Main Author:	Shah, Kifayat Ullah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Antibiotic therapy Antibiotics TJ Mechanical engineering and machinery
Online Access:	https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf
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id	my-uitm-ir.70900
record_format	uketd_dc
spelling	my-uitm-ir.709002024-02-27T02:41:39Z Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah 2017 Shah, Kifayat Ullah Antibiotic therapy. Antibiotics TJ Mechanical engineering and machinery The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method. 2017 Thesis https://ir.uitm.edu.my/id/eprint/70900/ https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Wong, Tin Wui
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wong, Tin Wui
topic	Antibiotic therapy Antibiotics TJ Mechanical engineering and machinery
spellingShingle	Antibiotic therapy Antibiotics TJ Mechanical engineering and machinery Shah, Kifayat Ullah Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
description	The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Shah, Kifayat Ullah
author_facet	Shah, Kifayat Ullah
author_sort	Shah, Kifayat Ullah
title	Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_short	Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full	Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_fullStr	Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full_unstemmed	Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_sort	liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / kifayat ullah shah
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf
_version_	1794191848922677248

Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah

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