LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali

LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali

The mineralocorticoid receptor (MR) is a well studied steroid hormone receptor known to be a key modulator of cardiovascular function and disease. Recent studies demonstrate that lysine specific demethylase 1 (LSDl) interacts with another steroid receptor, the androgen receptor, to modulate its tran...

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Main Author: Wan Razali, Wan Mohammad Hafiz
Format: Thesis
Language:English
Published: 2012
Subjects:
Cardiovascular system
Online Access:https://ir.uitm.edu.my/id/eprint/72167/1/72167.pdf
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spelling my-uitm-ir.721672024-01-02T08:45:35Z LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali 2012 Wan Razali, Wan Mohammad Hafiz Cardiovascular system RM Therapeutics. Pharmacology The mineralocorticoid receptor (MR) is a well studied steroid hormone receptor known to be a key modulator of cardiovascular function and disease. Recent studies demonstrate that lysine specific demethylase 1 (LSDl) interacts with another steroid receptor, the androgen receptor, to modulate its transcription function. In our laboratory we have demonstrated MR coimmunoprecipitates with LSDl, and potentially modulates MR's transcriptional activity. Furthermore, our lab has identified polymorphic variants in the LSDl gene in a subset of humans with salt sensitive hypertension, who have on a high salt (HS) diet decreased aldosterone responsiveness to infused angiotensin II, decreased aldosterone excretion on, and suppressed plasma renin activity (PRA) and on a low salt (LS) diet normal renin status. In addition hderozygous LSDl knockout (LSDl +/-) mice on a high-salt diet have salt sensitive hypertension associated with alterations in vascular contraction and the NO-cGMP pathway. 2012 Thesis https://ir.uitm.edu.my/id/eprint/72167/ https://ir.uitm.edu.my/id/eprint/72167/1/72167.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine E. Garza, Amanda
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor E. Garza, Amanda
topic Cardiovascular system
Cardiovascular system
spellingShingle Cardiovascular system
Cardiovascular system
Wan Razali, Wan Mohammad Hafiz
LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
description The mineralocorticoid receptor (MR) is a well studied steroid hormone receptor known to be a key modulator of cardiovascular function and disease. Recent studies demonstrate that lysine specific demethylase 1 (LSDl) interacts with another steroid receptor, the androgen receptor, to modulate its transcription function. In our laboratory we have demonstrated MR coimmunoprecipitates with LSDl, and potentially modulates MR's transcriptional activity. Furthermore, our lab has identified polymorphic variants in the LSDl gene in a subset of humans with salt sensitive hypertension, who have on a high salt (HS) diet decreased aldosterone responsiveness to infused angiotensin II, decreased aldosterone excretion on, and suppressed plasma renin activity (PRA) and on a low salt (LS) diet normal renin status. In addition hderozygous LSDl knockout (LSDl +/-) mice on a high-salt diet have salt sensitive hypertension associated with alterations in vascular contraction and the NO-cGMP pathway.
format Thesis
qualification_level Bachelor degree
author Wan Razali, Wan Mohammad Hafiz
author_facet Wan Razali, Wan Mohammad Hafiz
author_sort Wan Razali, Wan Mohammad Hafiz
title LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
title_short LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
title_full LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
title_fullStr LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
title_full_unstemmed LSD1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / Wan Mohammad Hafiz Wan Razali
title_sort lsd1 regulates aldosterone: mineralocorticoid receptor signaling in endothelial cell / wan mohammad hafiz wan razali
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Medicine
publishDate 2012
url https://ir.uitm.edu.my/id/eprint/72167/1/72167.pdf
_version_ 1794191886442823680

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