Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman

Lung cancer is the leading cause of cancer death worldwide and non-small cell lung cancer (NSCLC) accounts for almost 80% of such deaths. Non-small cell lung cancer (NSCLC) is considered as a heterogeneous disease; where patients with similar clinical and pathologic features show different outcomes:...

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Main Author:	Abd Rahman, Muhamad Asri
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Diseases of the lungs
Online Access:	https://ir.uitm.edu.my/id/eprint/72171/1/72171.pdf
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id	my-uitm-ir.72171
record_format	uketd_dc
spelling	my-uitm-ir.721712024-01-02T08:38:17Z Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman 2012 Abd Rahman, Muhamad Asri Diseases of the lungs Lung cancer is the leading cause of cancer death worldwide and non-small cell lung cancer (NSCLC) accounts for almost 80% of such deaths. Non-small cell lung cancer (NSCLC) is considered as a heterogeneous disease; where patients with similar clinical and pathologic features show different outcomes: some are cured, whereas in others, the cancer recurs. Hence, some patients may receive potentially toxic chemotherapy unnecessarily. The discovery of the epidermal growth factor receptor (EGFR) signaling pathway as a therapeutic target leads to the development of small molecule tyrosine kinase inhibitors (TKIs). However, EGFR protein overexpression in NSCLC varies in previous studies with some contradicting results. The aim of this study is to determine the expression pattern (membranous vs. cytoplasmic) and heterogeneity (percentage of positive tumour cells) of EGFR immunohistochemical staining in adenocarcinoma type of non small cell lung carcinoma. The samples were formalin-fixed and paraffin-embedded tissue. 2012 Thesis https://ir.uitm.edu.my/id/eprint/72171/ https://ir.uitm.edu.my/id/eprint/72171/1/72171.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Bakar, Nor Salmah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Bakar, Nor Salmah
topic	Diseases of the lungs
spellingShingle	Diseases of the lungs Abd Rahman, Muhamad Asri Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
description	Lung cancer is the leading cause of cancer death worldwide and non-small cell lung cancer (NSCLC) accounts for almost 80% of such deaths. Non-small cell lung cancer (NSCLC) is considered as a heterogeneous disease; where patients with similar clinical and pathologic features show different outcomes: some are cured, whereas in others, the cancer recurs. Hence, some patients may receive potentially toxic chemotherapy unnecessarily. The discovery of the epidermal growth factor receptor (EGFR) signaling pathway as a therapeutic target leads to the development of small molecule tyrosine kinase inhibitors (TKIs). However, EGFR protein overexpression in NSCLC varies in previous studies with some contradicting results. The aim of this study is to determine the expression pattern (membranous vs. cytoplasmic) and heterogeneity (percentage of positive tumour cells) of EGFR immunohistochemical staining in adenocarcinoma type of non small cell lung carcinoma. The samples were formalin-fixed and paraffin-embedded tissue.
format	Thesis
qualification_level	Bachelor degree
author	Abd Rahman, Muhamad Asri
author_facet	Abd Rahman, Muhamad Asri
author_sort	Abd Rahman, Muhamad Asri
title	Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
title_short	Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
title_full	Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
title_fullStr	Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
title_full_unstemmed	Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman
title_sort	immunohistochemical staining pattern of epidermal growth factor receptor (egfr) protein overexpression in non-small cell lung cancer / muhamad asri abd rahman
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/72171/1/72171.pdf
_version_	1794191887438970880

Immunohistochemical staining pattern of epidermal growth factor receptor (EGFR) protein overexpression in non-small cell lung cancer / Muhamad Asri Abd Rahman

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