Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman

An impressive number of medicinal plants contains high amount of flavonoids and antioxidant compound which are very useful as they promotes anti-inflammatory, anti-bacterial and various therapeutic values. Antibiotic resistance in human pathogens due to increasing abuse of drugs has reached an alarm...

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Main Author:	Othman, Nurul Asyikin
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Medical botany (General) Antibacterial agents
Online Access:	https://ir.uitm.edu.my/id/eprint/72173/1/72173.pdf
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id	my-uitm-ir.72173
record_format	uketd_dc
spelling	my-uitm-ir.721732024-01-05T01:43:51Z Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman 2012 Othman, Nurul Asyikin Medical botany (General) Antibacterial agents An impressive number of medicinal plants contains high amount of flavonoids and antioxidant compound which are very useful as they promotes anti-inflammatory, anti-bacterial and various therapeutic values. Antibiotic resistance in human pathogens due to increasing abuse of drugs has reached an alarming stage. The options in combating multiple drug resistance organisms are decreasing. Besides that, gastric ulcer has become a major problem worldwide. Acid, peptic activity and collapse of mucosal defense mechanism has been proven to be the pathological process in the formation of gastric ulcer. Proton-pump inhibitors have been introduced as the treatment. However, long term use of these drugs has been proven to cause various adverse effects. Hence, there is a need to develop new antimicrobial and antiulcer drugs. The purpose of this study was to investigate the antimicrobial and anti-ulcer activities of selected Malaysian medicinal plants in vitro. The medicinal plant extracts were tested by in vitro antibacterial test against six bacterial species, both Gram positive and Gram negative organisms. Disc diffusion assay was employed for assessing antimicrobial activity. The ethanol-induced gastric ulcer method in laboratory animals was used to determine anti-ulcer activity of the plants. Screening for antioxidant levels has also been carried out on the plant extracts. From this study, all plants were showed to have antibacterial activities within them except for Swietenia macrophylla. However, for antiulcer studies, all plants showed high antiulcer activity. As for the antioxidant screening, only two of the plants used were high in antioxidant level whereas the other two were not. 2012 Thesis https://ir.uitm.edu.my/id/eprint/72173/ https://ir.uitm.edu.my/id/eprint/72173/1/72173.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Houssaini, Jamal
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Houssaini, Jamal
topic	Medical botany (General) Antibacterial agents
spellingShingle	Medical botany (General) Antibacterial agents Othman, Nurul Asyikin Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
description	An impressive number of medicinal plants contains high amount of flavonoids and antioxidant compound which are very useful as they promotes anti-inflammatory, anti-bacterial and various therapeutic values. Antibiotic resistance in human pathogens due to increasing abuse of drugs has reached an alarming stage. The options in combating multiple drug resistance organisms are decreasing. Besides that, gastric ulcer has become a major problem worldwide. Acid, peptic activity and collapse of mucosal defense mechanism has been proven to be the pathological process in the formation of gastric ulcer. Proton-pump inhibitors have been introduced as the treatment. However, long term use of these drugs has been proven to cause various adverse effects. Hence, there is a need to develop new antimicrobial and antiulcer drugs. The purpose of this study was to investigate the antimicrobial and anti-ulcer activities of selected Malaysian medicinal plants in vitro. The medicinal plant extracts were tested by in vitro antibacterial test against six bacterial species, both Gram positive and Gram negative organisms. Disc diffusion assay was employed for assessing antimicrobial activity. The ethanol-induced gastric ulcer method in laboratory animals was used to determine anti-ulcer activity of the plants. Screening for antioxidant levels has also been carried out on the plant extracts. From this study, all plants were showed to have antibacterial activities within them except for Swietenia macrophylla. However, for antiulcer studies, all plants showed high antiulcer activity. As for the antioxidant screening, only two of the plants used were high in antioxidant level whereas the other two were not.
format	Thesis
qualification_level	Bachelor degree
author	Othman, Nurul Asyikin
author_facet	Othman, Nurul Asyikin
author_sort	Othman, Nurul Asyikin
title	Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
title_short	Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
title_full	Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
title_fullStr	Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
title_full_unstemmed	Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman
title_sort	anti-bacterial and anti-ulcer activity of selected malaysian medicinal plants / nurul asyikin othman
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/72173/1/72173.pdf
_version_	1794191887937044480

Anti-bacterial and anti-ulcer activity of selected Malaysian medicinal plants / Nurul Asyikin Othman

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