The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo
Mineralocorticoid receptor (MR) activation by aldosterone (ALDO) in the endothelial cells of the vascular system has been recognized as one of the many causes of hypertension. Previous studies from this laboratory has recently demonstrated that MR is present and functional in endothelial cells, co-l...
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2012
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my-uitm-ir.721782024-01-02T09:04:21Z The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo 2012 Mohd Hafiz Ngoo, Siti Khairani RM Therapeutics. Pharmacology Mineralocorticoid receptor (MR) activation by aldosterone (ALDO) in the endothelial cells of the vascular system has been recognized as one of the many causes of hypertension. Previous studies from this laboratory has recently demonstrated that MR is present and functional in endothelial cells, co-localizes and co-immunoprecipitates with caveolin-1 (CAV-1), suggesting a role of CAV-1 in modulating MR function. This is further supported by the presence of caveolin binding motifs on MR as well as evidence showing that CAV-1 KO has reduced ALDO-mediated vascular damage as compared to WT mice, implicating an interaction between MR and Cav-1. Despite the mounting evidence that MR and CAV-1 are associated in endothelial cells, the cross talk between the pathways mediated by these proteins remains vague. This study was designed to elucidate (1) the genomic effects of ALDO on MR and CAV-1 proteins, (2) the non-genomic effects of ALDO on CAV-1 and ERKl/2 phosphorylation, as well as (3) the role of CAV-1 in modulating these effects. 2012 Thesis https://ir.uitm.edu.my/id/eprint/72178/ https://ir.uitm.edu.my/id/eprint/72178/1/72178.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine H.Pojoga, Luminita E.Garza, Amanda |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
H.Pojoga, Luminita E.Garza, Amanda |
| topic |
RM Therapeutics Pharmacology |
| spellingShingle |
RM Therapeutics Pharmacology Mohd Hafiz Ngoo, Siti Khairani The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| description |
Mineralocorticoid receptor (MR) activation by aldosterone (ALDO) in the endothelial cells of the vascular system has been recognized as one of the many causes of hypertension. Previous studies from this laboratory has recently demonstrated that MR is present and functional in endothelial cells, co-localizes and co-immunoprecipitates with caveolin-1 (CAV-1), suggesting a role of CAV-1 in modulating MR function. This is further supported by the presence of caveolin binding motifs on MR as well as evidence showing that CAV-1 KO has reduced ALDO-mediated vascular damage as compared to WT mice, implicating an interaction between MR and Cav-1. Despite the mounting evidence that MR and CAV-1 are associated in endothelial cells, the cross talk between the pathways mediated by these proteins remains vague. This study was designed to elucidate (1) the genomic effects of ALDO on MR and CAV-1 proteins, (2) the non-genomic effects of ALDO on CAV-1 and ERKl/2 phosphorylation, as well as (3) the role of CAV-1 in modulating these effects. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Mohd Hafiz Ngoo, Siti Khairani |
| author_facet |
Mohd Hafiz Ngoo, Siti Khairani |
| author_sort |
Mohd Hafiz Ngoo, Siti Khairani |
| title |
The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| title_short |
The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| title_full |
The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| title_fullStr |
The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| title_full_unstemmed |
The role of caveolin-1 mediating the effects of aldosterone-mediated Mineralocorticoid receptor activation / Siti Khairani Mohd Hafiz Ngoo |
| title_sort |
role of caveolin-1 mediating the effects of aldosterone-mediated mineralocorticoid receptor activation / siti khairani mohd hafiz ngoo |
| granting_institution |
Universiti Teknologi MARA (UiTM) |
| granting_department |
Faculty of Medicine |
| publishDate |
2012 |
| url |
https://ir.uitm.edu.my/id/eprint/72178/1/72178.pdf |
| _version_ |
1794191889169121280 |