In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor

The antimicrobial activities of silver have been well known since ancient history. However, the effects of this compound against resistant organism have not been well explored. Multi drug resistant organisms have been taunting the medical world for the last few decades. Even with newly developed ant...

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Main Author:	Amirulhusni Alshukor, Athirah Nur
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/72179/1/72179.pdf
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id	my-uitm-ir.72179
record_format	uketd_dc
spelling	my-uitm-ir.721792024-01-02T09:04:19Z In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor 2012 Amirulhusni Alshukor, Athirah Nur RS Pharmacy and materia medica The antimicrobial activities of silver have been well known since ancient history. However, the effects of this compound against resistant organism have not been well explored. Multi drug resistant organisms have been taunting the medical world for the last few decades. Even with newly developed antibiotics, new resistant strains emerge soon after in many cases which leads to complications in treatment regiments. Colloidal silver was synthesized by adding an excess of the reducing agent NaBHi to AgNO3 which reduced the ionic silver into nanoparticle state. Optical characterization of the silver nanoparticles was done using UV-VIS spectroscopy and the particle size was analyzed using scanning electron microscope. Silver nanoparticles of spherical shape, 30 to 70 nm of size was successfully produced. We investigated silver in the form of nanoparticles for its antimicrobial activity against resistant strains of Pseudomonas aeruginosa. This organism is one of the most common multi drug resistant, opportunistic pathogens, contributing to the high morbidity and mortality in immune-compromised patients. Five strains of multi-drug resistant P. aeruginosa were selected from patients in Hospital Selayang, Malaysia as samples for this study. Antibacterial activity was evaluated by disc diffusion method, broth microdilution method and biofilm inhibition assay. 2012 Thesis https://ir.uitm.edu.my/id/eprint/72179/ https://ir.uitm.edu.my/id/eprint/72179/1/72179.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Palanisamy, Navindra Kumari
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Palanisamy, Navindra Kumari
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Amirulhusni Alshukor, Athirah Nur In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
description	The antimicrobial activities of silver have been well known since ancient history. However, the effects of this compound against resistant organism have not been well explored. Multi drug resistant organisms have been taunting the medical world for the last few decades. Even with newly developed antibiotics, new resistant strains emerge soon after in many cases which leads to complications in treatment regiments. Colloidal silver was synthesized by adding an excess of the reducing agent NaBHi to AgNO3 which reduced the ionic silver into nanoparticle state. Optical characterization of the silver nanoparticles was done using UV-VIS spectroscopy and the particle size was analyzed using scanning electron microscope. Silver nanoparticles of spherical shape, 30 to 70 nm of size was successfully produced. We investigated silver in the form of nanoparticles for its antimicrobial activity against resistant strains of Pseudomonas aeruginosa. This organism is one of the most common multi drug resistant, opportunistic pathogens, contributing to the high morbidity and mortality in immune-compromised patients. Five strains of multi-drug resistant P. aeruginosa were selected from patients in Hospital Selayang, Malaysia as samples for this study. Antibacterial activity was evaluated by disc diffusion method, broth microdilution method and biofilm inhibition assay.
format	Thesis
qualification_level	Bachelor degree
author	Amirulhusni Alshukor, Athirah Nur
author_facet	Amirulhusni Alshukor, Athirah Nur
author_sort	Amirulhusni Alshukor, Athirah Nur
title	In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
title_short	In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
title_full	In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
title_fullStr	In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
title_full_unstemmed	In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor
title_sort	in vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant pseudomonas aeruginosa / athirah nur amirulhusni alshukor
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/72179/1/72179.pdf
_version_	1794191889412390912

In vitro study to elucidate the antibacterial effect of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa / Athirah Nur Amirulhusni Alshukor

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