The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan

Magnesium taurate is a drug potentially effective in the treatment of cataracts. However, it is a highly hydrophilic compound, which greatly reduces its ophthalmic bioavailability. An effective way to increase the bioavailability is the application of nanotechnology, in particular, the creation of l...

Full description

Saved in:

Bibliographic Details
Main Author:	Azizan, Izza Liyana
Format:	Thesis
Language:	English
Published:	2013
Subjects:	QM Human anatomy Particular diseases of the eye
Online Access:	https://ir.uitm.edu.my/id/eprint/72185/1/72185.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.72185
record_format	uketd_dc
spelling	my-uitm-ir.721852024-01-04T06:13:21Z The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan 2013 Azizan, Izza Liyana QM Human anatomy Particular diseases of the eye Magnesium taurate is a drug potentially effective in the treatment of cataracts. However, it is a highly hydrophilic compound, which greatly reduces its ophthalmic bioavailability. An effective way to increase the bioavailability is the application of nanotechnology, in particular, the creation of liposomal drug form of magnesium taurate. Presence of amphipathic structures in liposomes facilitates their penetration into the tissue, increase the expense of bioavailability and thus increase distribution of drug throughout the ocular tissue. Liposomes were fabricated by lipid hydration method composed of L-a-phosphatidylcholine and cholesterol, dissolved in chloroform: methanol (5:1) mixture. The steps in the preparation of liposomes included evaporation, cycles of freeze-thaw, sonication and extrusion. After each step of preparation, the samples were collected and the size of liposomes was estimated using ultrasound Shockwave based and dynamic light scattering based zetasizer to compare the suitability of the zetasizer in measuring the size of liposome particle and to see the effectiveness of each steps in liposomal preparation in reducing the liposomal size. 5(6)-Carboxyfluorescein-contained liposome, a hydrophilic probe, was used to evaluate liposomal distribution in ocular tissue. 2013 Thesis https://ir.uitm.edu.my/id/eprint/72185/ https://ir.uitm.edu.my/id/eprint/72185/1/72185.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Alyautdin, Renad -, Alimah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Alyautdin, Renad -, Alimah
topic	QM Human anatomy Particular diseases of the eye
spellingShingle	QM Human anatomy Particular diseases of the eye Azizan, Izza Liyana The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
description	Magnesium taurate is a drug potentially effective in the treatment of cataracts. However, it is a highly hydrophilic compound, which greatly reduces its ophthalmic bioavailability. An effective way to increase the bioavailability is the application of nanotechnology, in particular, the creation of liposomal drug form of magnesium taurate. Presence of amphipathic structures in liposomes facilitates their penetration into the tissue, increase the expense of bioavailability and thus increase distribution of drug throughout the ocular tissue. Liposomes were fabricated by lipid hydration method composed of L-a-phosphatidylcholine and cholesterol, dissolved in chloroform: methanol (5:1) mixture. The steps in the preparation of liposomes included evaporation, cycles of freeze-thaw, sonication and extrusion. After each step of preparation, the samples were collected and the size of liposomes was estimated using ultrasound Shockwave based and dynamic light scattering based zetasizer to compare the suitability of the zetasizer in measuring the size of liposome particle and to see the effectiveness of each steps in liposomal preparation in reducing the liposomal size. 5(6)-Carboxyfluorescein-contained liposome, a hydrophilic probe, was used to evaluate liposomal distribution in ocular tissue.
format	Thesis
qualification_level	Bachelor degree
author	Azizan, Izza Liyana
author_facet	Azizan, Izza Liyana
author_sort	Azizan, Izza Liyana
title	The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
title_short	The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
title_full	The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
title_fullStr	The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
title_full_unstemmed	The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan
title_sort	development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / izza liyana azizan
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/72185/1/72185.pdf
_version_	1794191890902417408

The development and characterization of liposomal formulation of magnesium taurate and studies to evaluate its ocular distribution in cataract / Izza Liyana Azizan

Similar Items