Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham

Background and significance: Cardiovascular disease (CVD) is a multifactorial disorder resulting from both genetic and environment factors. Although there are many known environmental factors that contribute to CVD, the genetic underpinnings of CVD is less understood; and this is likely due to the c...

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Main Author:	Mohamed Hisham, Nur Hazirah
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Diseases of the circulatory (Cardiovascular) system Hypertension
Online Access:	https://ir.uitm.edu.my/id/eprint/72187/1/72187.pdf
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id	my-uitm-ir.72187
record_format	uketd_dc
spelling	my-uitm-ir.721872024-01-04T06:27:38Z Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham 2013 Mohamed Hisham, Nur Hazirah Diseases of the circulatory (Cardiovascular) system Hypertension Background and significance: Cardiovascular disease (CVD) is a multifactorial disorder resulting from both genetic and environment factors. Although there are many known environmental factors that contribute to CVD, the genetic underpinnings of CVD is less understood; and this is likely due to the complex relationship. With improvements in genetic technology, analysing the genetic underpinnings of CVD has become faster and less expensive. In this project, we evaluated the relationship between genetic variants of the endothelin receptor type A (EDNRA) gene and transcription factor 7-like 2 (TCF7L2) gene with hypertension and diabetes; two pathophysiological states that are highly associated with CVD. These genes may serve as markers for CVD. Methods: Using a candidate gene approach, we evaluated the relationship between genetic variants and distinct CVD phenotypes using the HyperP A TH cohort, a cohort consisting mostly of Caucasian individuals with mild hypertension, with or without diabetes. 683 and 344 individuals were studied for EDNRA and TCF7L2 project respectively. They completed two controlled dietary phases: high salt and low salt diet. 2013 Thesis https://ir.uitm.edu.my/id/eprint/72187/ https://ir.uitm.edu.my/id/eprint/72187/1/72187.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Underwood, Patricia -, Bei Sun
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Underwood, Patricia -, Bei Sun
topic	Diseases of the circulatory (Cardiovascular) system Hypertension
spellingShingle	Diseases of the circulatory (Cardiovascular) system Hypertension Mohamed Hisham, Nur Hazirah Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
description	Background and significance: Cardiovascular disease (CVD) is a multifactorial disorder resulting from both genetic and environment factors. Although there are many known environmental factors that contribute to CVD, the genetic underpinnings of CVD is less understood; and this is likely due to the complex relationship. With improvements in genetic technology, analysing the genetic underpinnings of CVD has become faster and less expensive. In this project, we evaluated the relationship between genetic variants of the endothelin receptor type A (EDNRA) gene and transcription factor 7-like 2 (TCF7L2) gene with hypertension and diabetes; two pathophysiological states that are highly associated with CVD. These genes may serve as markers for CVD. Methods: Using a candidate gene approach, we evaluated the relationship between genetic variants and distinct CVD phenotypes using the HyperP A TH cohort, a cohort consisting mostly of Caucasian individuals with mild hypertension, with or without diabetes. 683 and 344 individuals were studied for EDNRA and TCF7L2 project respectively. They completed two controlled dietary phases: high salt and low salt diet.
format	Thesis
qualification_level	Bachelor degree
author	Mohamed Hisham, Nur Hazirah
author_facet	Mohamed Hisham, Nur Hazirah
author_sort	Mohamed Hisham, Nur Hazirah
title	Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
title_short	Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
title_full	Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
title_fullStr	Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
title_full_unstemmed	Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham
title_sort	genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / nur hazirah mohamed hisham
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/72187/1/72187.pdf
_version_	1794191891406782464

Genotype-phenotype correlations in human cardiovascular diseases: focus on hypertension and diabetes / Nur Hazirah Mohamed Hisham

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