Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze

Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze

Cardiovascular (CV) disease has been implicated as the leading cause of death and remains one of the most complex disease due to its pathophysiology involving multiple organs systems. One of the many causes of hypertension, the most common CV disease, is activation of mineralocorticoid receptor (MR)...

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Main Author: Moizeze, Burhanuddin
Format: Thesis
Language:English
Published: 2013
Subjects:
RM Therapeutics
Pharmacology
Online Access:https://ir.uitm.edu.my/id/eprint/72188/1/72188.pdf
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spelling my-uitm-ir.721882024-01-05T03:38:39Z Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze 2013 Moizeze, Burhanuddin RM Therapeutics. Pharmacology Cardiovascular (CV) disease has been implicated as the leading cause of death and remains one of the most complex disease due to its pathophysiology involving multiple organs systems. One of the many causes of hypertension, the most common CV disease, is activation of mineralocorticoid receptor (MR) by aldosterone (ALDO). MR is a well-studied steroid hormone receptor and our laboratory has recently shown that MR co-immunoprecipitates with striatin, a novel scaffolding protein. Striatin potentially modulates MR's non-genomic functions. Furthermore, striatin polymorphism in humans is associated with salt sensitivity of blood pressure. Therefore, we investigated the role of striatin in modulating blood pressure along with modulation of MR's non-genomic functions using a genetically modified mouse model. 2013 Thesis https://ir.uitm.edu.my/id/eprint/72188/ https://ir.uitm.edu.my/id/eprint/72188/1/72188.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine E. Garza, Amanda
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor E. Garza, Amanda
topic RM Therapeutics
Pharmacology
spellingShingle RM Therapeutics
Pharmacology
Moizeze, Burhanuddin
Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
description Cardiovascular (CV) disease has been implicated as the leading cause of death and remains one of the most complex disease due to its pathophysiology involving multiple organs systems. One of the many causes of hypertension, the most common CV disease, is activation of mineralocorticoid receptor (MR) by aldosterone (ALDO). MR is a well-studied steroid hormone receptor and our laboratory has recently shown that MR co-immunoprecipitates with striatin, a novel scaffolding protein. Striatin potentially modulates MR's non-genomic functions. Furthermore, striatin polymorphism in humans is associated with salt sensitivity of blood pressure. Therefore, we investigated the role of striatin in modulating blood pressure along with modulation of MR's non-genomic functions using a genetically modified mouse model.
format Thesis
qualification_level Bachelor degree
author Moizeze, Burhanuddin
author_facet Moizeze, Burhanuddin
author_sort Moizeze, Burhanuddin
title Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
title_short Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
title_full Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
title_fullStr Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
title_full_unstemmed Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze
title_sort role of striatin and mineralocorticoid receptor (mr) in cardiovascular diseases / burhanuddin moizeze
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Medicine
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/72188/1/72188.pdf
_version_ 1794191891650052096

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