A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa

Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) are recognized as being useful for renoprotective in certain population of hypertensive patients, but both drugs are also known to be nephrotoxic and may induced acute kidney injury (AKI) by decreasing kidney perfu...

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Main Author:	Mustafa, Faridah Hanim
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Organic substances Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/73701/1/73701.pdf
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spelling	my-uitm-ir.737012023-03-24T01:21:58Z A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa 2015 Mustafa, Faridah Hanim Organic substances Drugs and their actions Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) are recognized as being useful for renoprotective in certain population of hypertensive patients, but both drugs are also known to be nephrotoxic and may induced acute kidney injury (AKI) by decreasing kidney perfusion. The objective of this study was to examine if taking ACEI or ARB is associated with risk of kidney injury. A retrospective records review study was done in Hospital Serdang, Selangor involving cases of cardiovascular patients. Three hundred and fifteen cases were reviewed. Forty nine cases were included in the analysis of AKI with eight cases (16.3%) showed declining eGFR >25% in seven days; however, there was no significant association (p>0.05) found between ACEI or ARB and AKI. Further analysis was done to identify the decline in eGFR>35% within three months. The decline in eGFR>35% within three months was lower (4%) compared to incidence of AKI and showed no significant association (p>0.05) with use of ACEI or ARB. The incidence of hyperkalemia was also documented with 5.6% (n=17) out of three hundred and one patients were having potassium level >5.0mmol/L; however, no significant association (p>0.05) found between ACEI or ARB and hyperkalemia. Factors associated with the decline in eGFR>35% within three months were identified using multivariate logistic regression analysis. The number of medications co prescribed with ACEI or ARB (OR=1.32, 95%CI 1.10-1.58) was the only one main factor that found to be significantly associated with the incidence of AKI. Extra caution should be exercised when ACEI or ARB is initiated together with diuretics, NSAIDs and other nephrotoxic agents that may precipitate renal insufficiency. 2015 Thesis https://ir.uitm.edu.my/id/eprint/73701/ https://ir.uitm.edu.my/id/eprint/73701/1/73701.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Hassan, Yahaya
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Hassan, Yahaya
topic	Organic substances Drugs and their actions
spellingShingle	Organic substances Drugs and their actions Mustafa, Faridah Hanim A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
description	Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) are recognized as being useful for renoprotective in certain population of hypertensive patients, but both drugs are also known to be nephrotoxic and may induced acute kidney injury (AKI) by decreasing kidney perfusion. The objective of this study was to examine if taking ACEI or ARB is associated with risk of kidney injury. A retrospective records review study was done in Hospital Serdang, Selangor involving cases of cardiovascular patients. Three hundred and fifteen cases were reviewed. Forty nine cases were included in the analysis of AKI with eight cases (16.3%) showed declining eGFR >25% in seven days; however, there was no significant association (p>0.05) found between ACEI or ARB and AKI. Further analysis was done to identify the decline in eGFR>35% within three months. The decline in eGFR>35% within three months was lower (4%) compared to incidence of AKI and showed no significant association (p>0.05) with use of ACEI or ARB. The incidence of hyperkalemia was also documented with 5.6% (n=17) out of three hundred and one patients were having potassium level >5.0mmol/L; however, no significant association (p>0.05) found between ACEI or ARB and hyperkalemia. Factors associated with the decline in eGFR>35% within three months were identified using multivariate logistic regression analysis. The number of medications co prescribed with ACEI or ARB (OR=1.32, 95%CI 1.10-1.58) was the only one main factor that found to be significantly associated with the incidence of AKI. Extra caution should be exercised when ACEI or ARB is initiated together with diuretics, NSAIDs and other nephrotoxic agents that may precipitate renal insufficiency.
format	Thesis
qualification_level	Master's degree
author	Mustafa, Faridah Hanim
author_facet	Mustafa, Faridah Hanim
author_sort	Mustafa, Faridah Hanim
title	A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
title_short	A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
title_full	A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
title_fullStr	A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
title_full_unstemmed	A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa
title_sort	retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / faridah hanim mustafa
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/73701/1/73701.pdf
_version_	1783735988652081152

A retrospective study on the use of angiotensin converting enzyme inhibitor/angiotensin receptor blocker and the incidence of acute kidney injury / Faridah Hanim Mustafa

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