Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri

Nickel is a metallic element widely used in dentistry and orthodontic materials. Although orthodontic appliances are biocompatible, there are documented effects associated with the release of nickel ions such as a higher risk of sensitivity and ion leaching due to intraoral chemical reaction. It has...

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Main Author:	Muhamad Sabri, Nadia Izyan
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Genetic engineering applications
Online Access:	https://ir.uitm.edu.my/id/eprint/75613/1/75613.pdf
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id	my-uitm-ir.75613
record_format	uketd_dc
spelling	my-uitm-ir.756132023-05-26T03:35:03Z Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri 2022 Muhamad Sabri, Nadia Izyan Genetic engineering applications Nickel is a metallic element widely used in dentistry and orthodontic materials. Although orthodontic appliances are biocompatible, there are documented effects associated with the release of nickel ions such as a higher risk of sensitivity and ion leaching due to intraoral chemical reaction. It has been postulated that even in small quantities, prolonged exposure to nickel is cytotoxic, genotoxic and carcinogenic. Previously, studies on nickel level focused on the before and during orthodontic treatment changes. However, there are insufficient reports on the nickel level post orthodontic treatment. This study aims to evaluate the salivary and urinary nickel level following the exposure of orthodontic fixed appliances at different time points. It was based on the data obtained from the saliva and urine samples of orthodontic patients at debonding (To), after one month (Ti), three months post-debonding (T2) and from control subjects without any history of orthodontic treatment. Saliva and urine samples were collected and stored at -20 °C. Samples were then prepared and analysed using Inductively Coupled Plasma Optical Mass Spectrometry (ICP-MS) to detect the mean nickel level in each sample. Statistical analyses were conducted using the Statistical Package for Social Science (IBM SPSS, Version 27). 2022 Thesis https://ir.uitm.edu.my/id/eprint/75613/ https://ir.uitm.edu.my/id/eprint/75613/1/75613.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Dentistry Noviaranny, Indah Yuri
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Noviaranny, Indah Yuri
topic	Genetic engineering applications
spellingShingle	Genetic engineering applications Muhamad Sabri, Nadia Izyan Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
description	Nickel is a metallic element widely used in dentistry and orthodontic materials. Although orthodontic appliances are biocompatible, there are documented effects associated with the release of nickel ions such as a higher risk of sensitivity and ion leaching due to intraoral chemical reaction. It has been postulated that even in small quantities, prolonged exposure to nickel is cytotoxic, genotoxic and carcinogenic. Previously, studies on nickel level focused on the before and during orthodontic treatment changes. However, there are insufficient reports on the nickel level post orthodontic treatment. This study aims to evaluate the salivary and urinary nickel level following the exposure of orthodontic fixed appliances at different time points. It was based on the data obtained from the saliva and urine samples of orthodontic patients at debonding (To), after one month (Ti), three months post-debonding (T2) and from control subjects without any history of orthodontic treatment. Saliva and urine samples were collected and stored at -20 °C. Samples were then prepared and analysed using Inductively Coupled Plasma Optical Mass Spectrometry (ICP-MS) to detect the mean nickel level in each sample. Statistical analyses were conducted using the Statistical Package for Social Science (IBM SPSS, Version 27).
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Muhamad Sabri, Nadia Izyan
author_facet	Muhamad Sabri, Nadia Izyan
author_sort	Muhamad Sabri, Nadia Izyan
title	Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
title_short	Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
title_full	Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
title_fullStr	Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
title_full_unstemmed	Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri
title_sort	salivary and urinary nickel level post orthodontic fixed appliance treatment / nadia izyan muhamad sabri
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Dentistry
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/75613/1/75613.pdf
_version_	1783736068538892288

Salivary and urinary nickel level post orthodontic fixed appliance treatment / Nadia Izyan Muhamad Sabri

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