Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli

Objective: Successful diabetes treatment requires commitment and understanding of disease management by the patients. This trial aimed to evaluate the clinical and economic impacts of home medication review by community pharmacists (HMR-CP) in optimising diabetes care and as a cost-effective interve...

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Main Author:	Rosli, Mohd Rozaini
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Diabetes Mellitus
Online Access:	https://ir.uitm.edu.my/id/eprint/75800/1/75800.pdf
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id	my-uitm-ir.75800
record_format	uketd_dc
spelling	my-uitm-ir.758002023-03-31T01:40:59Z Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli 2022 Rosli, Mohd Rozaini Diabetes Mellitus Objective: Successful diabetes treatment requires commitment and understanding of disease management by the patients. This trial aimed to evaluate the clinical and economic impacts of home medication review by community pharmacists (HMR-CP) in optimising diabetes care and as a cost-effective intervention from the Malaysian healthcare provider perspective. Methodology: A randomised controlled trial (RCT) was conducted on 166 patients with Type 2 Diabetes Mellitus (T2DM) who were randomly assigned to the intervention or control groups. The economic evaluation was conducted alongside the RCT to estimate the intermediate cost-effectiveness of HMR-CP for patients with T2DM. The intervention group received HMR-CP at 0-month, 3-month, and 6-month. The primary outcome was haemoglobin A1c (HbA1c) and quality-adjusted life-years (QALYs), while clinical outcomes, anthropometric data, and humanistic outcomes were the secondary outcomes. The utility value measured using five-level EuroQoL five-dimensional questionnaire (EQ-5D-5L). For the intervention group, drug-related problems (DRP) were classified according to the Pharmaceutical Care Network Europe Foundation (PCNE). Medication adherence was determined based on the Pill Counting Adherence Ratio (PCAR). The costs included in the studies was cost of implementing the intervention and the cost associated with the use of healthcare services. General linear model and generalised estimating equations were used to compare data across the different time-points within and between the groups, respectively. A Markov model was then constructed to project the lifetime cost-effectiveness data beyond the RCT. The primary outcomes for the economic evaluation were cost per HbA1c reduction and cost per quality-adjusted life-years (QALYs). 2022 Thesis https://ir.uitm.edu.my/id/eprint/75800/ https://ir.uitm.edu.my/id/eprint/75800/1/75800.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Karuppannan, Mahmathi
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Karuppannan, Mahmathi
topic	Diabetes Mellitus
spellingShingle	Diabetes Mellitus Rosli, Mohd Rozaini Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
description	Objective: Successful diabetes treatment requires commitment and understanding of disease management by the patients. This trial aimed to evaluate the clinical and economic impacts of home medication review by community pharmacists (HMR-CP) in optimising diabetes care and as a cost-effective intervention from the Malaysian healthcare provider perspective. Methodology: A randomised controlled trial (RCT) was conducted on 166 patients with Type 2 Diabetes Mellitus (T2DM) who were randomly assigned to the intervention or control groups. The economic evaluation was conducted alongside the RCT to estimate the intermediate cost-effectiveness of HMR-CP for patients with T2DM. The intervention group received HMR-CP at 0-month, 3-month, and 6-month. The primary outcome was haemoglobin A1c (HbA1c) and quality-adjusted life-years (QALYs), while clinical outcomes, anthropometric data, and humanistic outcomes were the secondary outcomes. The utility value measured using five-level EuroQoL five-dimensional questionnaire (EQ-5D-5L). For the intervention group, drug-related problems (DRP) were classified according to the Pharmaceutical Care Network Europe Foundation (PCNE). Medication adherence was determined based on the Pill Counting Adherence Ratio (PCAR). The costs included in the studies was cost of implementing the intervention and the cost associated with the use of healthcare services. General linear model and generalised estimating equations were used to compare data across the different time-points within and between the groups, respectively. A Markov model was then constructed to project the lifetime cost-effectiveness data beyond the RCT. The primary outcomes for the economic evaluation were cost per HbA1c reduction and cost per quality-adjusted life-years (QALYs).
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Rosli, Mohd Rozaini
author_facet	Rosli, Mohd Rozaini
author_sort	Rosli, Mohd Rozaini
title	Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
title_short	Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
title_full	Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
title_fullStr	Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
title_full_unstemmed	Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli
title_sort	economic evaluation and clinical impact of home medication review (hmr) by community pharmacists among patients with type 2 diabetes mellitus (t2dm) / mohd rozaini rosli
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/75800/1/75800.pdf
_version_	1783736084020068352

Economic evaluation and clinical impact of home medication review (HMR) by community pharmacists among patients with type 2 diabetes mellitus (T2DM) / Mohd Rozaini Rosli

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