Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat

Obesity has become a worldwide problem that can lead to various chronic diseases due to unhealthy diet and lifestyle. Honey has been identified as a food that has a positive effect in combating obesity. In this study, the effect of pineapple honey in combating obesity was investigated using in vivo...

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Main Author:	Samat, Suhana
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Honeycomb structure
Online Access:	https://ir.uitm.edu.my/id/eprint/75829/1/75829.pdf
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id	my-uitm-ir.75829
record_format	uketd_dc
spelling	my-uitm-ir.758292023-03-31T01:25:25Z Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat 2022 Samat, Suhana Honeycomb structure Obesity has become a worldwide problem that can lead to various chronic diseases due to unhealthy diet and lifestyle. Honey has been identified as a food that has a positive effect in combating obesity. In this study, the effect of pineapple honey in combating obesity was investigated using in vivo and in vitro models. The study started with a preliminary screening of selected honeys, namely gelam, acacia and pineapple honeys and two adulterated honeys available in the market. Physicochemical analysis revealed that gelam honey had the highest content of phenolic compounds and flavonoids, followed by pineapple honey. Meanwhile, parameters such as sugar profiles, HMF, and glucose oxidase activity tested for adulterated honey A and B did not fulfil standard quality factors set by the IHC Honey Board.The effect of honey in in vitro studies showed that Gelam, Acacia and pineapple honey at 25% v/v and above significantly (p < 0.05) inhibited adipogenesis in 3T3-L1 adipocytes by reducing lipid accumulation, Feret diameter and intracellular triglyceride content. In addition, Gelam, Acacia and pineapple honey significantly reduced the concentrations of leptin and resistin. The results suggest that honey may be involved in the control of adipocytokines in the process of adipogenesis. In vivo studies showed no abnormal changes in acute and subacute studies after administration of Acacia, Gelam and pineapple honey. In addition, obese rats fed pineapple honey (HFDPH) and orlistat (HFDO) had an obesity index ~4% lower than the HFD group 2022 Thesis https://ir.uitm.edu.my/id/eprint/75829/ https://ir.uitm.edu.my/id/eprint/75829/1/75829.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Eshak, Zolkapli
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Eshak, Zolkapli
topic	Honeycomb structure
spellingShingle	Honeycomb structure Samat, Suhana Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
description	Obesity has become a worldwide problem that can lead to various chronic diseases due to unhealthy diet and lifestyle. Honey has been identified as a food that has a positive effect in combating obesity. In this study, the effect of pineapple honey in combating obesity was investigated using in vivo and in vitro models. The study started with a preliminary screening of selected honeys, namely gelam, acacia and pineapple honeys and two adulterated honeys available in the market. Physicochemical analysis revealed that gelam honey had the highest content of phenolic compounds and flavonoids, followed by pineapple honey. Meanwhile, parameters such as sugar profiles, HMF, and glucose oxidase activity tested for adulterated honey A and B did not fulfil standard quality factors set by the IHC Honey Board.The effect of honey in in vitro studies showed that Gelam, Acacia and pineapple honey at 25% v/v and above significantly (p < 0.05) inhibited adipogenesis in 3T3-L1 adipocytes by reducing lipid accumulation, Feret diameter and intracellular triglyceride content. In addition, Gelam, Acacia and pineapple honey significantly reduced the concentrations of leptin and resistin. The results suggest that honey may be involved in the control of adipocytokines in the process of adipogenesis. In vivo studies showed no abnormal changes in acute and subacute studies after administration of Acacia, Gelam and pineapple honey. In addition, obese rats fed pineapple honey (HFDPH) and orlistat (HFDO) had an obesity index ~4% lower than the HFD group
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Samat, Suhana
author_facet	Samat, Suhana
author_sort	Samat, Suhana
title	Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
title_short	Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
title_full	Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
title_fullStr	Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
title_full_unstemmed	Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat
title_sort	physicochemical profile of selected malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / suhana samat
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/75829/1/75829.pdf
_version_	1783736085564620800

Physicochemical profile of selected Malaysian honey and the effect of pineapple honey on obesity in vitro and in vivo models / Suhana Samat

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