The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham

Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the p...

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Main Author: Mahamad Hazaham, Fatin Umirah
Format: Thesis
Language:English
Published: 2022
Subjects:
Online Access:https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf
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id my-uitm-ir.76712
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spelling my-uitm-ir.767122023-05-29T04:42:53Z The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham 2022 Mahamad Hazaham, Fatin Umirah Diabetes Mellitus Drugs and their actions Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the pathogenesis of T2DM, a systematic review was first conducted to critically appraise existing evidence of differential gut microbiota composition between T2DM and control groups as well as its correlation with metabolic parameters. Lactobacilli were found to predominate the gut of T2DM patients and correlated positively with glycaemic parameters. In contrast, butyrate producers dominated the gut of control group which can be seen by their negative correlations with glycaemic parameters. The shortlisted studies varied in terms of sample size, study design and population, which hindered meaningful general conclusions to be made. A case-control study was then designed and carried out to investigate the differential gut microbiota between T2DM patients and healthy control at local setting. 2022 Thesis https://ir.uitm.edu.my/id/eprint/76712/ https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Ramasamy, Kalavathy
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Ramasamy, Kalavathy
topic Diabetes Mellitus
Drugs and their actions
spellingShingle Diabetes Mellitus
Drugs and their actions
Mahamad Hazaham, Fatin Umirah
The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
description Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the pathogenesis of T2DM, a systematic review was first conducted to critically appraise existing evidence of differential gut microbiota composition between T2DM and control groups as well as its correlation with metabolic parameters. Lactobacilli were found to predominate the gut of T2DM patients and correlated positively with glycaemic parameters. In contrast, butyrate producers dominated the gut of control group which can be seen by their negative correlations with glycaemic parameters. The shortlisted studies varied in terms of sample size, study design and population, which hindered meaningful general conclusions to be made. A case-control study was then designed and carried out to investigate the differential gut microbiota between T2DM patients and healthy control at local setting.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Mahamad Hazaham, Fatin Umirah
author_facet Mahamad Hazaham, Fatin Umirah
author_sort Mahamad Hazaham, Fatin Umirah
title The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_short The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_full The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_fullStr The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_full_unstemmed The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_sort effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 diabetes mellitus patients / fatin umirah mahamad hazaham
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Pharmacy
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf
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