Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali

Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali

The aim of this study was to synthesize alginate incorporated graphene oxide (Alg/GO) for the extraction of selected non-steroidal anti-inflammatory drugs (NSAIDs) using dispersive micro-solid phase extraction (D-u-SPE) technique. The effects of GO and Alg amounts on the performance of the composite...

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Main Author: Chaman Ali, Mohammad Salim Tabish
Format: Thesis
Language:English
Published: 2019
Online Access:https://ir.uitm.edu.my/id/eprint/79249/1/79249.pdf
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spelling my-uitm-ir.792492023-09-08T04:08:25Z Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali 2019 Chaman Ali, Mohammad Salim Tabish The aim of this study was to synthesize alginate incorporated graphene oxide (Alg/GO) for the extraction of selected non-steroidal anti-inflammatory drugs (NSAIDs) using dispersive micro-solid phase extraction (D-u-SPE) technique. The effects of GO and Alg amounts on the performance of the composite beads were optimized. The sorbent Alg/GO (1.0:0.3 w/v %) was characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and Brunauer- Emmett-Teller (BET). FTIR results of Alg/GO beads showed intermolecular hydrogen bonds, n-n stacking and electrostatic interactions within the Alg/GO matrix. BET linear plot of adsorption/desorption isotherms showed that Alg/GO relates to the type IV mesoporous materials with a hysteresis loop of type H3. SEM analysis of Alg/GO beads revealed homogenous pores on the relatively rough surface of the sorbent. The synthesized material was utilized as a sorbent in D-u-SPE for extraction of three targeted analytes (ibuprofen, naproxen, and diclofenac) from water samples prior to analysis by high performance liquid chromatography-ultraviolet detector (HPLC-UV). Furthermore, eight most effective parameters of D-u-SPE technique were optimized using the prepared sorbent beads. The obtained optimum parameters are 0.15 g of mass of sorbent, sample pH 3,1000 rpm stirring speed, 30 min extraction time, 0 % (w/v) salt addition, isopropyl alcohol (IP A) as desorption solvent, 300 uL IP A as desorption solvent volume and 10 min desorption time. Under the optimized conditions, good linearity (r2 > 0.9993) over a concentration range 10-1000 ug L"1 and detection limits between 3.5 - 4.8 ug L"1 with a relative standard deviation of < 6 % were obtained. The proposed method also provided acceptable relative recoveries in the range of 95.6 -102.2 %. Alg/GO is found to be a potentially good alternative sorbent for the monitoring of pharmaceuticals in water samples using D-u-SPE technique. 2019 Thesis https://ir.uitm.edu.my/id/eprint/79249/ https://ir.uitm.edu.my/id/eprint/79249/1/79249.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Mohammad, Nor Suhaila
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Mohammad, Nor Suhaila
description The aim of this study was to synthesize alginate incorporated graphene oxide (Alg/GO) for the extraction of selected non-steroidal anti-inflammatory drugs (NSAIDs) using dispersive micro-solid phase extraction (D-u-SPE) technique. The effects of GO and Alg amounts on the performance of the composite beads were optimized. The sorbent Alg/GO (1.0:0.3 w/v %) was characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and Brunauer- Emmett-Teller (BET). FTIR results of Alg/GO beads showed intermolecular hydrogen bonds, n-n stacking and electrostatic interactions within the Alg/GO matrix. BET linear plot of adsorption/desorption isotherms showed that Alg/GO relates to the type IV mesoporous materials with a hysteresis loop of type H3. SEM analysis of Alg/GO beads revealed homogenous pores on the relatively rough surface of the sorbent. The synthesized material was utilized as a sorbent in D-u-SPE for extraction of three targeted analytes (ibuprofen, naproxen, and diclofenac) from water samples prior to analysis by high performance liquid chromatography-ultraviolet detector (HPLC-UV). Furthermore, eight most effective parameters of D-u-SPE technique were optimized using the prepared sorbent beads. The obtained optimum parameters are 0.15 g of mass of sorbent, sample pH 3,1000 rpm stirring speed, 30 min extraction time, 0 % (w/v) salt addition, isopropyl alcohol (IP A) as desorption solvent, 300 uL IP A as desorption solvent volume and 10 min desorption time. Under the optimized conditions, good linearity (r2 > 0.9993) over a concentration range 10-1000 ug L"1 and detection limits between 3.5 - 4.8 ug L"1 with a relative standard deviation of < 6 % were obtained. The proposed method also provided acceptable relative recoveries in the range of 95.6 -102.2 %. Alg/GO is found to be a potentially good alternative sorbent for the monitoring of pharmaceuticals in water samples using D-u-SPE technique.
format Thesis
qualification_level Master's degree
author Chaman Ali, Mohammad Salim Tabish
spellingShingle Chaman Ali, Mohammad Salim Tabish
Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
author_facet Chaman Ali, Mohammad Salim Tabish
author_sort Chaman Ali, Mohammad Salim Tabish
title Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
title_short Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
title_full Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
title_fullStr Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
title_full_unstemmed Dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / Mohammad Salim Tabish Chaman Ali
title_sort dispersive micro-solid phase extraction using alginate graphene oxide for the de-termination of selected non-steroidal anti-infl-ammatory drugs from water samples / mohammad salim tabish chaman ali
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Applied Sciences
publishDate 2019
url https://ir.uitm.edu.my/id/eprint/79249/1/79249.pdf
_version_ 1783736269546717184

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