Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman

Previous phytochemical and biological studies have revealed Calophyllum species are rich in phenolic constituents specifically xanthones and coumarins which possess a wide range of biological activities. For example, cytotoxicity, HIV-1 reverse transcriptase inhibitory activity, antisecretory, and c...

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Main Author:	Lizazman, Mas Atikah
Format:	Thesis
Language:	English
Published:	2022
Online Access:	https://ir.uitm.edu.my/id/eprint/82218/1/82218.pdf
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id	my-uitm-ir.82218
record_format	uketd_dc
spelling	my-uitm-ir.822182023-12-18T05:18:25Z Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman 2022 Lizazman, Mas Atikah Previous phytochemical and biological studies have revealed Calophyllum species are rich in phenolic constituents specifically xanthones and coumarins which possess a wide range of biological activities. For example, cytotoxicity, HIV-1 reverse transcriptase inhibitory activity, antisecretory, and cytoprotective properties as well as antinociceptive, molluscicidal, and antimicrobial effects. However, there are very few studies conducted on C. canum, the Calophyllum species from Sarawak. The evaluation of their neuroprotective properties has been least studied as well. Hence, this study is aimed to develop a chemical and biological database on the entities found in the C. canum. Several chromatographic techniques have been implemented for the isolation of pure compounds from the stem bark C. canum extracts. For instance, vacuum liquid chromatography, gravity column chromatography, and gel filtration chromatography were employed for fractionation of the plant extracts whilst radial chromatography was for the purification of the compounds. The structures of these compounds were identified and elucidated using advanced spectroscopic techniques such as 1D and 2D nuclear magnetic resonance, infrared, ultraviolet, mass spectroscopy, and comparison with the reported data. 2022 Thesis https://ir.uitm.edu.my/id/eprint/82218/ https://ir.uitm.edu.my/id/eprint/82218/1/82218.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Jong Yi Mian, Vivien
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Jong Yi Mian, Vivien
description	Previous phytochemical and biological studies have revealed Calophyllum species are rich in phenolic constituents specifically xanthones and coumarins which possess a wide range of biological activities. For example, cytotoxicity, HIV-1 reverse transcriptase inhibitory activity, antisecretory, and cytoprotective properties as well as antinociceptive, molluscicidal, and antimicrobial effects. However, there are very few studies conducted on C. canum, the Calophyllum species from Sarawak. The evaluation of their neuroprotective properties has been least studied as well. Hence, this study is aimed to develop a chemical and biological database on the entities found in the C. canum. Several chromatographic techniques have been implemented for the isolation of pure compounds from the stem bark C. canum extracts. For instance, vacuum liquid chromatography, gravity column chromatography, and gel filtration chromatography were employed for fractionation of the plant extracts whilst radial chromatography was for the purification of the compounds. The structures of these compounds were identified and elucidated using advanced spectroscopic techniques such as 1D and 2D nuclear magnetic resonance, infrared, ultraviolet, mass spectroscopy, and comparison with the reported data.
format	Thesis
qualification_level	Master's degree
author	Lizazman, Mas Atikah
spellingShingle	Lizazman, Mas Atikah Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
author_facet	Lizazman, Mas Atikah
author_sort	Lizazman, Mas Atikah
title	Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
title_short	Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
title_full	Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
title_fullStr	Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
title_full_unstemmed	Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman
title_sort	phytochemical study of calophyllum canum hook. f. ex t. anderson and its neuroprotective evaluation in an in vitro pc12 cell-based stroke model / mas atikah lizazman
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/82218/1/82218.pdf
_version_	1794191924595261440

Phytochemical study of Calophyllum canum Hook. F. ex T. Anderson and its neuroprotective evaluation in an in vitro PC12 cell-based stroke model / Mas Atikah Lizazman

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