PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi

This study involved assessment of clinician’s views on practicality, clinical efficacy and cost –effectiveness of PET-CT in oesophageal cancer management and decision making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in oesophageal cancer management stag...

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Main Author:	Azmi, Nor Aniza
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC Internal Medicine
Online Access:	https://ir.uitm.edu.my/id/eprint/82867/1/82867.pdf
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id	my-uitm-ir.82867
record_format	uketd_dc
spelling	my-uitm-ir.828672024-02-02T02:48:18Z PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi 2018 Azmi, Nor Aniza RC Internal Medicine Research. Experimentation This study involved assessment of clinician’s views on practicality, clinical efficacy and cost –effectiveness of PET-CT in oesophageal cancer management and decision making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in oesophageal cancer management staging based on review of publications and retrospective data. Total of 73 clinicians included in the survey. Retrospective analysis of patient data from 2001-2008 taken from Royal Liverpool &Broadgreen University Hospital Trust (RLBUHT) medical records and North West Cancer Intelligence Services (NWCIS) database for the same period. A decision tree was developed using TREEAGE software. The relevant data on accuracy, sensitivity and specificity of each diagnostic test were linked in the model, to cost and the primary outcome measure, cost per quality-adjusted life-year (QALY). The model estimated the mean cost associated with each diagnostic procedure and assumed that patients entering the model were aged 35-75 years. The results of the cost-effectiveness analysis are presented in terms of the incremental cost-effectiveness ratios (ICERs).PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package become more expensive with each additional diagnostic test added to PET and the more effective in terms of QALYs gained. The conventional work-up is the preferred options as probabilistic sensitivity analysis shows at a willingness-to-pay (WTP) threshold of £ 20,000 per QALY. 2018 Thesis https://ir.uitm.edu.my/id/eprint/82867/ https://ir.uitm.edu.my/id/eprint/82867/1/82867.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Health Sciences Abdul Razak, Hairil Rashmizal
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Razak, Hairil Rashmizal
topic	RC Internal Medicine RC Internal Medicine
spellingShingle	RC Internal Medicine RC Internal Medicine Azmi, Nor Aniza PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
description	This study involved assessment of clinician’s views on practicality, clinical efficacy and cost –effectiveness of PET-CT in oesophageal cancer management and decision making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in oesophageal cancer management staging based on review of publications and retrospective data. Total of 73 clinicians included in the survey. Retrospective analysis of patient data from 2001-2008 taken from Royal Liverpool &Broadgreen University Hospital Trust (RLBUHT) medical records and North West Cancer Intelligence Services (NWCIS) database for the same period. A decision tree was developed using TREEAGE software. The relevant data on accuracy, sensitivity and specificity of each diagnostic test were linked in the model, to cost and the primary outcome measure, cost per quality-adjusted life-year (QALY). The model estimated the mean cost associated with each diagnostic procedure and assumed that patients entering the model were aged 35-75 years. The results of the cost-effectiveness analysis are presented in terms of the incremental cost-effectiveness ratios (ICERs).PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package become more expensive with each additional diagnostic test added to PET and the more effective in terms of QALYs gained. The conventional work-up is the preferred options as probabilistic sensitivity analysis shows at a willingness-to-pay (WTP) threshold of £ 20,000 per QALY.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Azmi, Nor Aniza
author_facet	Azmi, Nor Aniza
author_sort	Azmi, Nor Aniza
title	PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
title_short	PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
title_full	PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
title_fullStr	PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
title_full_unstemmed	PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
title_sort	pet-ct in oesophageal cancer management: a cost effectiveness analysis (cea) / nor aniza azmi
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Health Sciences
publishDate	2018
url	https://ir.uitm.edu.my/id/eprint/82867/1/82867.pdf
_version_	1794191950626160640

PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi

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