Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak

Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak

Memantine (MEM) is a NMDA receptor antagonist that has been demonstrated to be effective in the treatment of patients with Alzheimer’s disease (AD) does not across the blood brain barrier (BBB) readily. This work attempted to improve the brain targeting efficiency of MEM by encapsulating the drug in...

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Main Author: Abd Razak, Marsita
Format: Thesis
Language:English
Published: 2019
Subjects:
Alzheimer's disease
Online Access:https://ir.uitm.edu.my/id/eprint/82983/1/82983.pdf
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spelling my-uitm-ir.829832024-03-04T01:44:01Z Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak 2019 Abd Razak, Marsita Alzheimer's disease Memantine (MEM) is a NMDA receptor antagonist that has been demonstrated to be effective in the treatment of patients with Alzheimer’s disease (AD) does not across the blood brain barrier (BBB) readily. This work attempted to improve the brain targeting efficiency of MEM by encapsulating the drug in the novel cross linked itaconic acid-nvinylcaprolactam- polyethylene glycol (INP) nanoparticles. A novel INP nanoparticle as a carrier for MEM was formulated using the aqueous dispersion polymerization method (ADP). MEM was loaded in the polymer nanoparticles by remote loading method. MEM loaded polymeric nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), wide angle X-ray diffraction (WAXD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Particles size and surface charge on the polymeric nanoparticles were evaluated by Zetasizer. WAXD analysis revealed an amorphous nature of the blend polymeric nanoparticles; probably due to the increased composition of itaconic acid (IA). MEM was completely dispersed at the molecular level in the polymer nanoparticles. The blank nanoparticles showed uniform spherical nanoparticles with size ranging from 80 - 180 nm. 2019 Thesis https://ir.uitm.edu.my/id/eprint/82983/ https://ir.uitm.edu.my/id/eprint/82983/1/82983.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Majeed, Abu Bakar
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Majeed, Abu Bakar
topic Alzheimer's disease
spellingShingle Alzheimer's disease
Abd Razak, Marsita
Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
description Memantine (MEM) is a NMDA receptor antagonist that has been demonstrated to be effective in the treatment of patients with Alzheimer’s disease (AD) does not across the blood brain barrier (BBB) readily. This work attempted to improve the brain targeting efficiency of MEM by encapsulating the drug in the novel cross linked itaconic acid-nvinylcaprolactam- polyethylene glycol (INP) nanoparticles. A novel INP nanoparticle as a carrier for MEM was formulated using the aqueous dispersion polymerization method (ADP). MEM was loaded in the polymer nanoparticles by remote loading method. MEM loaded polymeric nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), wide angle X-ray diffraction (WAXD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Particles size and surface charge on the polymeric nanoparticles were evaluated by Zetasizer. WAXD analysis revealed an amorphous nature of the blend polymeric nanoparticles; probably due to the increased composition of itaconic acid (IA). MEM was completely dispersed at the molecular level in the polymer nanoparticles. The blank nanoparticles showed uniform spherical nanoparticles with size ranging from 80 - 180 nm.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Abd Razak, Marsita
author_facet Abd Razak, Marsita
author_sort Abd Razak, Marsita
title Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
title_short Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
title_full Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
title_fullStr Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
title_full_unstemmed Intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate Alzheimer’s disease / Marsita Abd Razak
title_sort intranasal route using novel polymeric nanoparticles as possible delivery strategy of drugs to alleviate alzheimer’s disease / marsita abd razak
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Pharmacy
publishDate 2019
url https://ir.uitm.edu.my/id/eprint/82983/1/82983.pdf
_version_ 1794191960377917440

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