Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry

Malaysia is rich with many medicinal plants and fruits which are well known for its traditional medicinal value. Some of these plants even contributed in healing and providing ailments towards certain diseases. Recent interest in the health-promoting properties of these Malaysian plants has been bas...

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Main Author:	Henry, Deborah David
Format:	Thesis
Language:	English
Published:	2016
Online Access:	https://ir.uitm.edu.my/id/eprint/84258/1/84258.pdf
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id	my-uitm-ir.84258
record_format	uketd_dc
spelling	my-uitm-ir.842582024-02-19T04:16:45Z Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry 2016 Henry, Deborah David Malaysia is rich with many medicinal plants and fruits which are well known for its traditional medicinal value. Some of these plants even contributed in healing and providing ailments towards certain diseases. Recent interest in the health-promoting properties of these Malaysian plants has been based on facts about their benefits in health. However, insufficient scientific information is available to support these facts. The overall objectives of this study were to evaluate and investigate the mutagenicity, cytotoxicity and genotoxicity of these three species of selected Malaysian plants (Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo). These tests included the mutagenicity test performed based on OECD guidelines section #471 that was proposed by Maron and Ames (1983), in vitro micronucleus test subjected to OECD guidelines #487using Chinese hamster lung cell (V79) and neutral red uptake cytotoxicity assay using normal mouse fibroblast cell (NIH/3T3). In bacterial reverse mutation test, A.bilimbi fruit extracts, C. caudatus and P. bleo plant extracts were treated onto Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537). 2016 Thesis https://ir.uitm.edu.my/id/eprint/84258/ https://ir.uitm.edu.my/id/eprint/84258/1/84258.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Abdullah, Mohd Faiz Foong
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdullah, Mohd Faiz Foong
description	Malaysia is rich with many medicinal plants and fruits which are well known for its traditional medicinal value. Some of these plants even contributed in healing and providing ailments towards certain diseases. Recent interest in the health-promoting properties of these Malaysian plants has been based on facts about their benefits in health. However, insufficient scientific information is available to support these facts. The overall objectives of this study were to evaluate and investigate the mutagenicity, cytotoxicity and genotoxicity of these three species of selected Malaysian plants (Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo). These tests included the mutagenicity test performed based on OECD guidelines section #471 that was proposed by Maron and Ames (1983), in vitro micronucleus test subjected to OECD guidelines #487using Chinese hamster lung cell (V79) and neutral red uptake cytotoxicity assay using normal mouse fibroblast cell (NIH/3T3). In bacterial reverse mutation test, A.bilimbi fruit extracts, C. caudatus and P. bleo plant extracts were treated onto Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537).
format	Thesis
qualification_level	Master's degree
author	Henry, Deborah David
spellingShingle	Henry, Deborah David Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
author_facet	Henry, Deborah David
author_sort	Henry, Deborah David
title	Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
title_short	Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
title_full	Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
title_fullStr	Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
title_full_unstemmed	Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry
title_sort	genotoxicity and cytotoxicity studies of averrhoa bilimbi, cosmos caudatus and pereskia bleo extract / deborah david henry
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/84258/1/84258.pdf
_version_	1794191986712903680

Genotoxicity and cytotoxicity studies of Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo extract / Deborah David Henry

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