Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad

Nasal delivery is an alternative route of delivery to deliver levodopa (L-dopa) to the brain. It provides high permeability towards drugs in the nasal epithelium, rapid absorption across the central nervous system (CNS) and avoidance of first-pass metabolism. Importantly, transport of exogenous mate...

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Main Author:	Ahmad, Mohd Zulhelmy
Format:	Thesis
Language:	English
Published:	2018
Online Access:	https://ir.uitm.edu.my/id/eprint/85910/1/85910.pdf
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id	my-uitm-ir.85910
record_format	uketd_dc
spelling	my-uitm-ir.859102024-03-27T01:17:05Z Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad 2018 Ahmad, Mohd Zulhelmy Nasal delivery is an alternative route of delivery to deliver levodopa (L-dopa) to the brain. It provides high permeability towards drugs in the nasal epithelium, rapid absorption across the central nervous system (CNS) and avoidance of first-pass metabolism. Importantly, transport of exogenous materials directly from nose-to-brain is a potential route for bypassing the blood brain barrier (BBB). In this study, we developed a carrier system for L-dopa using polymers such as poly lactic co-glycolic acid (PLGA) and chitosan. Screening of suitable polymers as a drug carrier is important to ensure optimum percentage of L-dopa encapsulated in the carrier system. Total of three formulations (P1, P2 and P3) using PLGA nanoparticles were prepared using modified water in oil in water (W/O/W) solvent evaporation technique while four formulations of chitosan nanoparticles (C1, C2, C3 and C4) were prepared by ionic gelation method with sodium tripolyphosphate as a crosslinking agent. 2018 Thesis https://ir.uitm.edu.my/id/eprint/85910/ https://ir.uitm.edu.my/id/eprint/85910/1/85910.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Abdul Hamid, Khuriah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Hamid, Khuriah
description	Nasal delivery is an alternative route of delivery to deliver levodopa (L-dopa) to the brain. It provides high permeability towards drugs in the nasal epithelium, rapid absorption across the central nervous system (CNS) and avoidance of first-pass metabolism. Importantly, transport of exogenous materials directly from nose-to-brain is a potential route for bypassing the blood brain barrier (BBB). In this study, we developed a carrier system for L-dopa using polymers such as poly lactic co-glycolic acid (PLGA) and chitosan. Screening of suitable polymers as a drug carrier is important to ensure optimum percentage of L-dopa encapsulated in the carrier system. Total of three formulations (P1, P2 and P3) using PLGA nanoparticles were prepared using modified water in oil in water (W/O/W) solvent evaporation technique while four formulations of chitosan nanoparticles (C1, C2, C3 and C4) were prepared by ionic gelation method with sodium tripolyphosphate as a crosslinking agent.
format	Thesis
qualification_level	Master's degree
author	Ahmad, Mohd Zulhelmy
spellingShingle	Ahmad, Mohd Zulhelmy Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
author_facet	Ahmad, Mohd Zulhelmy
author_sort	Ahmad, Mohd Zulhelmy
title	Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
title_short	Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
title_full	Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
title_fullStr	Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
title_full_unstemmed	Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad
title_sort	design and development of polymeric levodopa nanoparticles for intranasal drug delivery / mohd zulhelmy ahmad
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2018
url	https://ir.uitm.edu.my/id/eprint/85910/1/85910.pdf
_version_	1804889743232598016

Design and development of polymeric levodopa nanoparticles for intranasal drug delivery / Mohd Zulhelmy Ahmad

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