The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri

Diffuse large B-cell lymphoma (DLBCL) is the most common Non-Hodgkin lymphoma worldwide. It can be classified into two prognostic subgroups, germinal centre B-cell (GCB) and non-GCB (NGCB) subtypes using an immunohistochemistry (IHC) panel comprising of CD10, BCL6, and MUM1 according to Hans Algorit...

Full description

Saved in:

Bibliographic Details
Main Author:	Sobri, Siti Shakinah
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Clinical pathology Laboratory technique Cancer
Online Access:	https://ir.uitm.edu.my/id/eprint/88871/1/88871.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.88871
record_format	uketd_dc
spelling	my-uitm-ir.888712024-01-03T08:15:19Z The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri 2020 Sobri, Siti Shakinah Clinical pathology. Laboratory technique Cancer Diffuse large B-cell lymphoma (DLBCL) is the most common Non-Hodgkin lymphoma worldwide. It can be classified into two prognostic subgroups, germinal centre B-cell (GCB) and non-GCB (NGCB) subtypes using an immunohistochemistry (IHC) panel comprising of CD10, BCL6, and MUM1 according to Hans Algorithm (HA) while Muris algorithm (MA) incorporate BCL2 as a prognostic marker. Modified Hans (MH) used only CD10 and MUM1 in the algorithm. We had analysed 97 cases extracted from laboratory information system and review of IHC according to HA, MH and MA to determine the prevalence of DLBCL subtypes and agreement between the three and its prognostic significance. NGCB subtype predominates in HA and MH by 60.8% (59 cases) and 68.04% (66 cases) respectively but was reversed to GCB subtype, 53.61% (52 cases) when MA applied. Kappa agreement was strong, moderate, and weak for HA versus MH, HA versus MA and MH versus MA, respectively. BCL6 and MUM1 showed significant result in term of survival status (p= 0.038 and 0.002, respectively) and BCL2+ patient who did not received chemotherapy showed higher number of deaths (p=0.000). MA showed patients with NGCB subtype had inferior outcome with greater number of death (p=0.039). High agreement between HA and MH may suggest the possibility of using MH in the future but correlation with molecular profiling is recommended in the future. BCL2 had proved its prognostic significance in this study that patients may be benefited for anti-BCL2 targeted therapy. 2020 Thesis https://ir.uitm.edu.my/id/eprint/88871/ https://ir.uitm.edu.my/id/eprint/88871/1/88871.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Mohd Kornain, Assoc. Prof. Dr. Noor Kaslina
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohd Kornain, Assoc. Prof. Dr. Noor Kaslina
topic	Clinical pathology Laboratory technique Cancer
spellingShingle	Clinical pathology Laboratory technique Cancer Sobri, Siti Shakinah The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
description	Diffuse large B-cell lymphoma (DLBCL) is the most common Non-Hodgkin lymphoma worldwide. It can be classified into two prognostic subgroups, germinal centre B-cell (GCB) and non-GCB (NGCB) subtypes using an immunohistochemistry (IHC) panel comprising of CD10, BCL6, and MUM1 according to Hans Algorithm (HA) while Muris algorithm (MA) incorporate BCL2 as a prognostic marker. Modified Hans (MH) used only CD10 and MUM1 in the algorithm. We had analysed 97 cases extracted from laboratory information system and review of IHC according to HA, MH and MA to determine the prevalence of DLBCL subtypes and agreement between the three and its prognostic significance. NGCB subtype predominates in HA and MH by 60.8% (59 cases) and 68.04% (66 cases) respectively but was reversed to GCB subtype, 53.61% (52 cases) when MA applied. Kappa agreement was strong, moderate, and weak for HA versus MH, HA versus MA and MH versus MA, respectively. BCL6 and MUM1 showed significant result in term of survival status (p= 0.038 and 0.002, respectively) and BCL2+ patient who did not received chemotherapy showed higher number of deaths (p=0.000). MA showed patients with NGCB subtype had inferior outcome with greater number of death (p=0.039). High agreement between HA and MH may suggest the possibility of using MH in the future but correlation with molecular profiling is recommended in the future. BCL2 had proved its prognostic significance in this study that patients may be benefited for anti-BCL2 targeted therapy.
format	Thesis
qualification_level	Master's degree
author	Sobri, Siti Shakinah
author_facet	Sobri, Siti Shakinah
author_sort	Sobri, Siti Shakinah
title	The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
title_short	The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
title_full	The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
title_fullStr	The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
title_full_unstemmed	The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri
title_sort	prevalence of germinal centre b-cell and nongerminal centre b-cell subtypes of diffuse large b-cell lymphomas (hans algorithm) in hospital sultanah bahiyah: a comparison with modified hans and muris algorithms / siti shakinah sobri
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2020
url	https://ir.uitm.edu.my/id/eprint/88871/1/88871.pdf
_version_	1794192168897740800

The prevalence of germinal centre B-cell and nongerminal centre B-cell subtypes of diffuse large B-cell lymphomas (hans algorithm) in Hospital Sultanah Bahiyah: a comparison with modified hans and muris algorithms / Siti Shakinah Sobri

Similar Items