Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel

Extensive study on the isolation has been carried out on the stem bark of Morinda citrifolia. The synthesis of metal complexes were carried out using one pot reaction method. This study focused on the isolation of two anthraquinones, nordamnacanthal (10) and damnacanthal (11) and four synthesized me...

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Main Author:	Zaidel, Nur Dzaina
Format:	Thesis
Language:	English
Published:	2019
Online Access:	https://ir.uitm.edu.my/id/eprint/89219/1/89219.pdf
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id	my-uitm-ir.89219
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spelling	my-uitm-ir.892192024-08-16T01:59:43Z Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel 2019 Zaidel, Nur Dzaina Extensive study on the isolation has been carried out on the stem bark of Morinda citrifolia. The synthesis of metal complexes were carried out using one pot reaction method. This study focused on the isolation of two anthraquinones, nordamnacanthal (10) and damnacanthal (11) and four synthesized metal complexes, Cu- nordamnacanthal complex (163), Fe-nordamnacanthal complex (164), Cu- damnacanthal complex (165) and Zn-damnacanthal complex (166).The ligands were characterized using spectroscopic method sucah as NMR, MS, FTIR and UV-Vis. The spectroscopy data of the two ligands obtained were compared with the previous literature. The synthesized metal complexes obtained were characterized using CHNS elemental analysis, FTIR and UV-Vis. From the analysis results, the geometry of the Cu-nordamnacanthal was confirmed as square planar while geometry for Fe- nordamnacanthal, Cu-damnacanthal and Zn-damnacanthal were confirmed as octahedral. The crude extracts of Morinda citrifolia, the isolated anthraquinones and their metal complexes were then tested for their antimicrobial and antioxidant activities. Antimicrobial activity was carried out using five different strains of bacteria namely Escherichia coli, Salmonella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella pneumoniae. From the antimicrobial and antioxidant activities evaluation results, the synthesized metal complexes showed better antimicrobial activity and more potent antioxidant activity compared to the crude extracts and isolated anthraquinones, nordamnacanthal (10) and damnacanthal (11). 2019 Thesis https://ir.uitm.edu.my/id/eprint/89219/ https://ir.uitm.edu.my/id/eprint/89219/1/89219.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Science Jong Yi Mian, Vivien
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Jong Yi Mian, Vivien
description	Extensive study on the isolation has been carried out on the stem bark of Morinda citrifolia. The synthesis of metal complexes were carried out using one pot reaction method. This study focused on the isolation of two anthraquinones, nordamnacanthal (10) and damnacanthal (11) and four synthesized metal complexes, Cu- nordamnacanthal complex (163), Fe-nordamnacanthal complex (164), Cu- damnacanthal complex (165) and Zn-damnacanthal complex (166).The ligands were characterized using spectroscopic method sucah as NMR, MS, FTIR and UV-Vis. The spectroscopy data of the two ligands obtained were compared with the previous literature. The synthesized metal complexes obtained were characterized using CHNS elemental analysis, FTIR and UV-Vis. From the analysis results, the geometry of the Cu-nordamnacanthal was confirmed as square planar while geometry for Fe- nordamnacanthal, Cu-damnacanthal and Zn-damnacanthal were confirmed as octahedral. The crude extracts of Morinda citrifolia, the isolated anthraquinones and their metal complexes were then tested for their antimicrobial and antioxidant activities. Antimicrobial activity was carried out using five different strains of bacteria namely Escherichia coli, Salmonella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella pneumoniae. From the antimicrobial and antioxidant activities evaluation results, the synthesized metal complexes showed better antimicrobial activity and more potent antioxidant activity compared to the crude extracts and isolated anthraquinones, nordamnacanthal (10) and damnacanthal (11).
format	Thesis
qualification_level	Master's degree
author	Zaidel, Nur Dzaina
spellingShingle	Zaidel, Nur Dzaina Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
author_facet	Zaidel, Nur Dzaina
author_sort	Zaidel, Nur Dzaina
title	Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
title_short	Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
title_full	Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
title_fullStr	Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
title_full_unstemmed	Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel
title_sort	isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / nur dzaina zaidel
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Science
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/89219/1/89219.pdf
_version_	1811768743599013888

Isolation of anthraquinones from morinda citrifolia and semi-synthesis of its metal complexes / Nur Dzaina Zaidel

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