In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin
Wounds and their treatment significantly strain the healthcare system in terms of cost, time, and energy expended. The productivity and quality of life setbacks are incalculable. Herbal remedies are widely used in complementary and alternative medicine worldwide. Rhodomyrtus tomentosa leaves or know...
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| Language: | English |
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2023
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| Online Access: | https://ir.uitm.edu.my/id/eprint/89510/1/89510.pdf |
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my-uitm-ir.895102024-01-16T03:10:04Z In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin 2023 Kamarudin, Evana Wounds and their treatment significantly strain the healthcare system in terms of cost, time, and energy expended. The productivity and quality of life setbacks are incalculable. Herbal remedies are widely used in complementary and alternative medicine worldwide. Rhodomyrtus tomentosa leaves or known as "Kemunting", which are traditionally claimed to treat wounds, have not been proven scientifically. This research aimed to elucidate the mechanism of action of rhodomyrtone, Fraction 5-ethylacetate (F5-EA) of R. tomentosa crude ethanolic extract (SERT) in enhancing the wound healing through Wnt/fi-catenin pathway. The first part of this study wasconducted to profile SERT, identify, and quantify rhodomyrtone in liquid-liquidextraction (LLE) Fractions 1 - 6 of the SERT by conducting liquid chromatography -mass spectrophotometry (LCMS). Free radical scavenging activity (DPPH) was used to assess the antioxidant activity of SERT and LLE Fractions 1-6. 2023 Thesis https://ir.uitm.edu.my/id/eprint/89510/ https://ir.uitm.edu.my/id/eprint/89510/1/89510.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Health Sciences Tengku Ahmad Basri, Tengku Shahrul Anuar (Assoc. Prof. Ts Dr.) |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Tengku Ahmad Basri, Tengku Shahrul Anuar (Assoc. Prof. Ts Dr.) |
| description |
Wounds and their treatment significantly strain the healthcare system in terms of cost, time, and energy expended. The productivity and quality of life setbacks are incalculable. Herbal remedies are widely used in complementary and alternative medicine worldwide. Rhodomyrtus tomentosa leaves or known as "Kemunting", which are traditionally claimed to treat wounds, have not been proven scientifically. This research aimed to elucidate the mechanism of action of rhodomyrtone, Fraction 5-ethylacetate (F5-EA) of R. tomentosa crude ethanolic extract (SERT) in enhancing the wound healing through Wnt/fi-catenin pathway. The first part of this study wasconducted to profile SERT, identify, and quantify rhodomyrtone in liquid-liquidextraction (LLE) Fractions 1 - 6 of the SERT by conducting liquid chromatography -mass spectrophotometry (LCMS). Free radical scavenging activity (DPPH) was used to assess the antioxidant activity of SERT and LLE Fractions 1-6. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Kamarudin, Evana |
| spellingShingle |
Kamarudin, Evana In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| author_facet |
Kamarudin, Evana |
| author_sort |
Kamarudin, Evana |
| title |
In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| title_short |
In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| title_full |
In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| title_fullStr |
In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| title_full_unstemmed |
In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin |
| title_sort |
in vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / evana kamarudin |
| granting_institution |
Universiti Teknologi MARA (UiTM) |
| granting_department |
Faculty of Health Sciences |
| publishDate |
2023 |
| url |
https://ir.uitm.edu.my/id/eprint/89510/1/89510.pdf |
| _version_ |
1794192222649843712 |