Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi

Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkal...

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Main Author:	Azmi, Adiez Sapura
Format:	Thesis
Language:	English
Published:	2023
Subjects:	QK Botany
Online Access:	https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf
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id	my-uitm-ir.91034
record_format	uketd_dc
spelling	my-uitm-ir.910342024-03-18T00:56:28Z Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi 2023 Azmi, Adiez Sapura QK Botany Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkaloidal content, there is currently no scientific data available to support these claims, particularly regarding the antibacterial activity of the plant against bacterial strains commonly responsible for human infections. Therefore, the objectives of this study were; 1) to extracts alkaloids from E. fusca's, leaves using a tartaric and hydrochloric acids through acid-base extraction, 2) to evaluate the antibacterial activity of extracts obtained from different parts of E.fusca (leaves, twigs, and flowers) against four human infectious bacterial strains, namely Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, and Enterobacter aerogenes; 3) to profile and identify the phytochemicals present in the extracts, 4) to determine the variation of phytochemicals between the extracts and the correlation with their antibacterial activity. The antibacterial activity was evaluated using well diffusion method with ciprofloxacin as the positive control. The phytochemicals were profiled and identified using proton nuclear magnetic resonance (JH NMR)-based data analysis, while the phytochemicals variation between different extracts and their correlation with antibacterial activity were determined using principal component analysis (PCA), partial least square discriminant analysis (PLS-DA) and partial least square (PLS) regression. 2023 Thesis https://ir.uitm.edu.my/id/eprint/91034/ https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Salim, Fatimah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Salim, Fatimah
topic	QK Botany
spellingShingle	QK Botany Azmi, Adiez Sapura Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
description	Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkaloidal content, there is currently no scientific data available to support these claims, particularly regarding the antibacterial activity of the plant against bacterial strains commonly responsible for human infections. Therefore, the objectives of this study were; 1) to extracts alkaloids from E. fusca's, leaves using a tartaric and hydrochloric acids through acid-base extraction, 2) to evaluate the antibacterial activity of extracts obtained from different parts of E.fusca (leaves, twigs, and flowers) against four human infectious bacterial strains, namely Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, and Enterobacter aerogenes; 3) to profile and identify the phytochemicals present in the extracts, 4) to determine the variation of phytochemicals between the extracts and the correlation with their antibacterial activity. The antibacterial activity was evaluated using well diffusion method with ciprofloxacin as the positive control. The phytochemicals were profiled and identified using proton nuclear magnetic resonance (JH NMR)-based data analysis, while the phytochemicals variation between different extracts and their correlation with antibacterial activity were determined using principal component analysis (PCA), partial least square discriminant analysis (PLS-DA) and partial least square (PLS) regression.
format	Thesis
qualification_level	Master's degree
author	Azmi, Adiez Sapura
author_facet	Azmi, Adiez Sapura
author_sort	Azmi, Adiez Sapura
title	Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_short	Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_full	Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_fullStr	Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_full_unstemmed	Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_sort	profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton nmr-based chemometric approach / adiez sapura azmi
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf
_version_	1794192252991438848

Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi

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