Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir

The number of Malaysians diagnosed with diabetes is increasing by year whom experiences side effects from the prescribed commercial medicine. Meanwhile, corn husks are one of the most generated agricultural by-products which being discarded as waste after its harvesting season. It shown a great pote...

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Main Author:	Mohd Nasir, Nur Shahirah
Format:	Thesis
Language:	English
Published:	2023
Subjects:	Extraction (Chemistry)
Online Access:	https://ir.uitm.edu.my/id/eprint/93617/1/93617.pdf
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id	my-uitm-ir.93617
record_format	uketd_dc
spelling	my-uitm-ir.936172024-05-28T01:48:30Z Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir 2023-08 Mohd Nasir, Nur Shahirah Extraction (Chemistry) The number of Malaysians diagnosed with diabetes is increasing by year whom experiences side effects from the prescribed commercial medicine. Meanwhile, corn husks are one of the most generated agricultural by-products which being discarded as waste after its harvesting season. It shown a great potential in its biological properties, green energy, and materials industry. This study was aimed to investigate the in vitro antidiabetic activity of the methanolic extracts of corn husk by using α-amylase inhibitory assay and reducing sugar content, and antioxidant activity by using DPPH assay and total phenolic content. Extraction of corn husk by maceration method using methanol has yielded 0.5 % of extracts. The in vitro antidiabetic activities were determined based on α-amylase inhibitory activity exhibits an IC50 = 2.77 mg/mL which was compared to acarbose (positive control) with IC50 = 1.43 mg / mL and reducing sugar content using 3,5-dinitrosalicylic acid (DNSA) method (145.24 ± 5.78 mg GE/g). The methanolic extract of corn husk was further analysed for antioxidant activities using DPPH assay which exhibits an IC50 = 41.03 mg/mL and compared to ascorbic acid as positive control (IC50 = 15.92 mg/mL) and total phenolic content using Folin–Ciocalteu’s method (26.45 ± 0.17 mg GAE/g). The present result suggests that methanolic extracts of corn husk has the potential to be an alternative medicine for type 2 diabetes. 2023-08 Thesis https://ir.uitm.edu.my/id/eprint/93617/ https://ir.uitm.edu.my/id/eprint/93617/1/93617.pdf text en public Universiti Teknologi MARA, Perlis Faculty of Applied Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Extraction (Chemistry)
spellingShingle	Extraction (Chemistry) Mohd Nasir, Nur Shahirah Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
description	The number of Malaysians diagnosed with diabetes is increasing by year whom experiences side effects from the prescribed commercial medicine. Meanwhile, corn husks are one of the most generated agricultural by-products which being discarded as waste after its harvesting season. It shown a great potential in its biological properties, green energy, and materials industry. This study was aimed to investigate the in vitro antidiabetic activity of the methanolic extracts of corn husk by using α-amylase inhibitory assay and reducing sugar content, and antioxidant activity by using DPPH assay and total phenolic content. Extraction of corn husk by maceration method using methanol has yielded 0.5 % of extracts. The in vitro antidiabetic activities were determined based on α-amylase inhibitory activity exhibits an IC50 = 2.77 mg/mL which was compared to acarbose (positive control) with IC50 = 1.43 mg / mL and reducing sugar content using 3,5-dinitrosalicylic acid (DNSA) method (145.24 ± 5.78 mg GE/g). The methanolic extract of corn husk was further analysed for antioxidant activities using DPPH assay which exhibits an IC50 = 41.03 mg/mL and compared to ascorbic acid as positive control (IC50 = 15.92 mg/mL) and total phenolic content using Folin–Ciocalteu’s method (26.45 ± 0.17 mg GAE/g). The present result suggests that methanolic extracts of corn husk has the potential to be an alternative medicine for type 2 diabetes.
format	Thesis
author	Mohd Nasir, Nur Shahirah
author_facet	Mohd Nasir, Nur Shahirah
author_sort	Mohd Nasir, Nur Shahirah
title	Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
title_short	Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
title_full	Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
title_fullStr	Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
title_full_unstemmed	Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir
title_sort	antidiabetic and antioxidant activities of methanolic extracts from corn husk / nur shahirah mohd nasir
granting_institution	Universiti Teknologi MARA, Perlis
granting_department	Faculty of Applied Sciences
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/93617/1/93617.pdf
_version_	1804889886961958912

Antidiabetic and antioxidant activities of methanolic extracts from corn husk / Nur Shahirah Mohd Nasir

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