Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin

Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin

Aim: The purpose of the study was to determine the prevalence of RA-ILD and identify its associated factors. Methods: This is a cross-sectional study involving 156 RA patients who fulfilled 2010 ACR/EULAR criteria done from December 2020 to May 2021. Data on patient’s demographic, serologic marker...

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Main Author: Shariffudin, Suhaili
Format: Thesis
Language:English
Published: 2021
Subjects:
Diseases of the lungs
Online Access:https://ir.uitm.edu.my/id/eprint/93912/1/93912.pdf
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spelling my-uitm-ir.939122024-08-21T08:47:41Z Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin 2021 Shariffudin, Suhaili Diseases of the lungs Aim: The purpose of the study was to determine the prevalence of RA-ILD and identify its associated factors. Methods: This is a cross-sectional study involving 156 RA patients who fulfilled 2010 ACR/EULAR criteria done from December 2020 to May 2021. Data on patient’s demographic, serologic markers, and treatment history was collected. Clinical characteristics and treatment history were analysed in univariate and multivariate analysis. Results: 156 RA patients (female 90.4%) with mean age of 56.57 ± 13.19 were included in the study. Sixteen patients were diagnosed as having RA-ILD (10.3%). In univariate analysis, the factors associated with RA-ILD were older age (66.19 ± 9.40 vs 55.47 ± 13.14 years old, p=0.002), , Indian race (68.8% vs 29.3%, p=0.002), mMRC score of 2 to 4 (62.5% vs 12.1%, p<0.001) and not on Methotrexate (MTX) (68.8% vs 35%, p=0.013). In multivariate analysis, age (adjusted OR 1.09; p=0.026), Indian race (adjusted OR 8.05; p=0.005), mMRC score of 2 to 4 (adjusted OR 12.93; p<0.001) and patients who were not currently on MTX treatment (adjusted OR 0.15; p=0.009) were independent significant associated factors for RA-ILD. Conclusion: Factors associated with RA-ILD were older age, Indian race, higher mMRC score, and not currently on Methotrexate. Faculty of Medicine 2021 Thesis https://ir.uitm.edu.my/id/eprint/93912/ https://ir.uitm.edu.my/id/eprint/93912/1/93912.pdf text en public masters Universiti Teknologi MARA Faculty of Medicine
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
topic Diseases of the lungs
spellingShingle Diseases of the lungs
Shariffudin, Suhaili
Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
description Aim: The purpose of the study was to determine the prevalence of RA-ILD and identify its associated factors. Methods: This is a cross-sectional study involving 156 RA patients who fulfilled 2010 ACR/EULAR criteria done from December 2020 to May 2021. Data on patient’s demographic, serologic markers, and treatment history was collected. Clinical characteristics and treatment history were analysed in univariate and multivariate analysis. Results: 156 RA patients (female 90.4%) with mean age of 56.57 ± 13.19 were included in the study. Sixteen patients were diagnosed as having RA-ILD (10.3%). In univariate analysis, the factors associated with RA-ILD were older age (66.19 ± 9.40 vs 55.47 ± 13.14 years old, p=0.002), , Indian race (68.8% vs 29.3%, p=0.002), mMRC score of 2 to 4 (62.5% vs 12.1%, p<0.001) and not on Methotrexate (MTX) (68.8% vs 35%, p=0.013). In multivariate analysis, age (adjusted OR 1.09; p=0.026), Indian race (adjusted OR 8.05; p=0.005), mMRC score of 2 to 4 (adjusted OR 12.93; p<0.001) and patients who were not currently on MTX treatment (adjusted OR 0.15; p=0.009) were independent significant associated factors for RA-ILD. Conclusion: Factors associated with RA-ILD were older age, Indian race, higher mMRC score, and not currently on Methotrexate.
format Thesis
qualification_level Master's degree
author Shariffudin, Suhaili
author_facet Shariffudin, Suhaili
author_sort Shariffudin, Suhaili
title Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
title_short Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
title_full Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
title_fullStr Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
title_full_unstemmed Rheumatoid arthritis-interstitial lung disease in a rheumatology centre in Malaysia: prevalence and its associated factors / Suhaili Shariffudin
title_sort rheumatoid arthritis-interstitial lung disease in a rheumatology centre in malaysia: prevalence and its associated factors / suhaili shariffudin
granting_institution Universiti Teknologi MARA
granting_department Faculty of Medicine
publishDate 2021
url https://ir.uitm.edu.my/id/eprint/93912/1/93912.pdf
_version_ 1811768774068535296

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