Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa

Background : Stichopus horrens (sea cucumber) and Channa striatus (haruan fish) have been shown to effectively expedite wound healing process[1-6] and to treat multiple inflammatory disease. We aimed to assess the combination benefits of Stichopus horrens (SH) and Channa striatus (CS) in the treatme...

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主要作者:	Mustaffa, Noor Shazana
格式:	Thesis
语言:	English
出版:	2021
主题:	Eczema
在线阅读:	https://ir.uitm.edu.my/id/eprint/93936/1/93936.pdf
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id	my-uitm-ir.93936
record_format	uketd_dc
spelling	my-uitm-ir.939362024-08-21T08:46:30Z Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa 2021 Mustaffa, Noor Shazana Eczema Background : Stichopus horrens (sea cucumber) and Channa striatus (haruan fish) have been shown to effectively expedite wound healing process[1-6] and to treat multiple inflammatory disease. We aimed to assess the combination benefits of Stichopus horrens (SH) and Channa striatus (CS) in the treatment of chronic inflammatory skin disease like stasis eczema. Methods: This was a single center, randomized prospective, parallel, double-blinded comparative trial in patient with stasis eczema. Subjects were randomized 1:1 to receive either Treatment A (Stichopus horrens and Channa Striatus based cleanser and moisturizer) or Treatment B (Cetrimide lotion 1% and Petrolatum) which are to be used 3 times a day for 2 weeks. Clinical assessment was done using DASI score and DLQI which was assessed at week 0,1 and 2. Results: A total of 116 subjects were screened successfully and underwent this trial. From this trial, we found that Treatment A (Stichopus horrens and Channa Striatus based cleanser and moisturizer) has significant effect on improving sign of skin inflammation in stasis eczema (mean reduction for DASI Total W2 – W0: - 2.19 vs – 1.14, p-value < 0.001) and improves the patient quality of life (mean reduction DLQI W2 – W0 : - 1.00 vs – 0.62, p-value < 0.001) as compared to Treatment B (Cetrimide lotion 1% and Petrolatum). There is no adverse effect observed in both treatment arm Conclusions: Stichopus horrens and Channa striatus based cleanser and moisturizer can be used as an adjunct therapy in the treatment of stasis eczema. Faculty of Medicine 2021 Thesis https://ir.uitm.edu.my/id/eprint/93936/ https://ir.uitm.edu.my/id/eprint/93936/1/93936.pdf text en public masters Universiti Teknologi MARA Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Eczema
spellingShingle	Eczema Mustaffa, Noor Shazana Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
description	Background : Stichopus horrens (sea cucumber) and Channa striatus (haruan fish) have been shown to effectively expedite wound healing process[1-6] and to treat multiple inflammatory disease. We aimed to assess the combination benefits of Stichopus horrens (SH) and Channa striatus (CS) in the treatment of chronic inflammatory skin disease like stasis eczema. Methods: This was a single center, randomized prospective, parallel, double-blinded comparative trial in patient with stasis eczema. Subjects were randomized 1:1 to receive either Treatment A (Stichopus horrens and Channa Striatus based cleanser and moisturizer) or Treatment B (Cetrimide lotion 1% and Petrolatum) which are to be used 3 times a day for 2 weeks. Clinical assessment was done using DASI score and DLQI which was assessed at week 0,1 and 2. Results: A total of 116 subjects were screened successfully and underwent this trial. From this trial, we found that Treatment A (Stichopus horrens and Channa Striatus based cleanser and moisturizer) has significant effect on improving sign of skin inflammation in stasis eczema (mean reduction for DASI Total W2 – W0: - 2.19 vs – 1.14, p-value < 0.001) and improves the patient quality of life (mean reduction DLQI W2 – W0 : - 1.00 vs – 0.62, p-value < 0.001) as compared to Treatment B (Cetrimide lotion 1% and Petrolatum). There is no adverse effect observed in both treatment arm Conclusions: Stichopus horrens and Channa striatus based cleanser and moisturizer can be used as an adjunct therapy in the treatment of stasis eczema.
format	Thesis
qualification_level	Master's degree
author	Mustaffa, Noor Shazana
author_facet	Mustaffa, Noor Shazana
author_sort	Mustaffa, Noor Shazana
title	Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
title_short	Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
title_full	Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
title_fullStr	Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
title_full_unstemmed	Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa
title_sort	randomized trial to assess the efficacy of combined stichopus horrens and channa striatus based cleanser and moisturizer compared to cetrimide lotion 1% and petrolatum in treatment of stasis eczema / noor shazana mustaffa
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2021
url	https://ir.uitm.edu.my/id/eprint/93936/1/93936.pdf
_version_	1811768775842725888

Randomized trial to assess the efficacy of combined Stichopus horrens and Channa striatus based cleanser and moisturizer compared to Cetrimide Lotion 1% and Petrolatum in treatment of stasis eczema / Noor Shazana Mustaffa

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